The association between red blood cell distribution width and acute pancreatitis associated lung injury in patients with acute pancreatitis

Abstract

BackgroundRed blood cell distribution width (RDW) that describes red blood cell volume heterogeneity is a common laboratory test. Our aim was to focus on the association between RDW and acute pancreatitis associated lung injury (APALI).MethodologyA total of 152 acute pancreatitis (AP) patients who conformed to the criteria were included in this study. The demographic data, medical histories and laboratory measures was obtained from each patient on admission, further, the medical histories and biological data were analyzed, retrospectively.ResultsIncreased RDW at admission was observed in patients with APALI compared with the non-APALI groups. Our results exhibited that RDW was an independent risk factor for APALI after adjusting leukocyte, neutrophil percentage, random blood glucose (RBG), total bilirubin (TB) and total bile acid (TBA) (Crude model) (OR=2.671;CI 95% 1.145–6.230; P=0.023), further adjustment based on Crude model for sex and age did not attenuate the significantly high risk of APALI in patients with AP, RWD still remained a roles as an independent risk factor for APALI (OR=2.653;CI95 % 1.123–6.138; P=0.026).ConclusionsOur study demonstrate that RDW at admission is associated with APALI and should be considered as an underlying risk factor of APALI.

Prognostic significance of red blood cell distribution width in gastrointestinal disorders

“…However, patients with anemia, malignancy, kidney and hepatic diseases were also included in the final analysis, so potentially flawing the outcome[ 66 ]. Notably, Peng et al[ 67 ] also showed that a high RDW at admission was an independent risk factor for acute pancreatitis-associated lung injury (OR = 2.671, 95%CI: 1.145-6.138; P = 0.026).…”

Relation between changes in red blood cell distribution width after coronary artery bypass grafting and early postoperative morbidity

“…

been reported to independently predict morbidity and mortality (8)(9)(10)(11)(12).RDW changes rapidly in acute disease as well as chronic disease (13,14). Dabbah et al reported RDW elevation during hospitalization after acute myocardial infarction (AMI) is associated with an adverse clinical outcome (13).

…”

Diagnosis of microcytic hypochromic anemia with red blood cell survival via carbon monoxide breath-red blood cell survival

“…Where HGB is the hemoglobin concentration (g/L), 1380 is the constant K and endPco is the mean endogenous CO production fraction. (Peng et al, 2015;Strauss et al, 2004)…”

“…MRL is analogous to the area under the receiver operating characteristic (ROC) curve (AUC) or mean residence time (MRT) in pharmacokinetics (PK) studies. It is defined as the AUC of the fraction of the transfused RBCS remaining in the circulation versus time (Peng et al, 2015). This is in fact an estimate of mean residual lifespan (Mitlyng et al, 2006).…”