We examined whether parental major depressive disorder (MDD) is associated with course of depression and other psychopathology among formerly depressed adolescents as they enter adulthood. The sample consisted of 244 individuals (age 24) in a longitudinal study who had experienced MDD by 19. Maternal MDD was associated with MDD recurrence, chronicity, and severity, anxiety disorders, and (among sons only) lower psychosocial functioning in offspring between 19-24. Paternal MDD was associated with lower functioning. Sons of depressed fathers had elevated suicidal ideation and attempt rates in young adulthood. Recurrent paternal MDD was associated with depression recurrence in daughters but not sons. The impact of parental MDD on offspring could not be attributed to characteristics of the offspring's depression prior to 19.
Association of Parental Depression with Psychiatric Course from Adolescence to Young Adulthood among Formerly Depressed IndividualsIt is well-established that major depressive disorder (MDD) is a condition occurring in early adolescence, with the female preponderance emerging at that time and levels quickly reaching rates comparable to adults (e.g., Kashani et al., 1987;Lewinsohn, Hops, Roberts, Seeley, & Andrews, 1993;McGee et al., 1990). Recent studies exploring the longitudinal course of adolescent MDD (e.g., Harrington, Fudge, Rutter, Pickles, & Hill, 1990;Lewinsohn, Rohde, Klein, & Seeley, 1999;Rao et al., 1999;Reinherz, Giaconia, Hauf, Wasserman, & Silverman, 1999;Weissman et al., 1999) indicate that while most depressed adolescents recover from the index MDD episode, the risk of depression recurrence and psychiatric comorbidity in young adulthood is substantial.