The association between prenatal exposure to polycyclic aromatic hydrocarbons and birth weight: A meta-analysis

Yang, Lei; Shang, Li; Wang, Shanshan; Yang, Wenfang; Huang, Liyan; Qi, Cuifang; Gurcan, Anil; Yang, Zixuan; Chung, Mei

doi:10.1371/journal.pone.0236708

Cited by 16 publications

(7 citation statements)

References 46 publications

(75 reference statements)

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“…Conversely, some authors reported an association between PAHs and increased T3 and T3/T4 ratio, but not with TSH or T4 concentrations, which the authors suggested was a lack of negative feedback on TSH by T3 and increased thyroid activity. 33 A positive association between high PAHs concentrations and risk for low IQ in childhood, low birth length, and attention deficit hyperactivity disorder has been reported. 33 The observed significantly higher levels of BaP in this study align with previous studies in the Niger Delta region of Nigeria, 34 which reported significantly higher levels of BaP on the surface sediments and waters of a flow station and its environs in the Niger Delta which was above the WHO recommended limits.…”

Section: Discussionmentioning

confidence: 99%

“…33 A positive association between high PAHs concentrations and risk for low IQ in childhood, low birth length, and attention deficit hyperactivity disorder has been reported. 33 The observed significantly higher levels of BaP in this study align with previous studies in the Niger Delta region of Nigeria, 34 which reported significantly higher levels of BaP on the surface sediments and waters of a flow station and its environs in the Niger Delta which was above the WHO recommended limits. Similarly, significantly higher amounts of BaP in the soil of Yenagoa town, Bayelsa State were recently reported.…”

Section: Discussionmentioning

confidence: 99%

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Thyroid Hormone Levels in Mothers and Cord Blood at Delivery in Crude Oil Producing Community in Delta State, Nigeria

Emokpae,

Ogana

2024

Explor Res Hypothesis Med

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Background and objectives: Harm caused by crude oil spillage and its associated environmental toxicants manifests slowly. This study examined the impact of crude oil environmental toxicants on neonates' thyroid and cognitive functions in crude oil-producing communities. Methods:The case-control study comprised 55 crude oil-exposed expectant mothers and 33 non-crude oil-exposed expectant mothers as controls. Serum Benzo Pyrene Dihydrodiol Epoxide (BPDE), triiodothyronine (T3), thyroxine (T4), and thyroid stimulating hormone (TSH) were assayed in expectant mothers and neonates. Intelligence quotient and APGAR scores were determined in the children using Fagan's test of infant intelligence.Results: Serum TSH (p < 0.05) and BPDE (p < 0.001) were higher, while T3 and T3/T4 ratio were significantly lower (p < 0.001) in exposed pregnant women compared to the control. Cord blood TSH and T3/T4 ratio were lower (p < 0.001) while T4 and BDPE were higher (p < 0.001) in prenatally exposed neonates than prenatally non-exposed infants. Serum TSH correlated with BDPE (R 2 = 0.080, p < 0.036) and APGAR score (R 2 = 0.341, p < 0.012), while T3 and T4 were not associated with BDPE and APGAR score. TSH correlated with T3 (R 2 = 0.0.082, p < 0.05), T3 correlated with T4 (R2 = 0.111, p < 0.013) and TSH (R 2 = 0.082, p < 0.05). Exactly 54.5% (30/55) of prenatally exposed neonates had a low intelligence quotient compared to 36.4% (12/33) in prenatally non-exposed neonates. Conclusion:Crude oil and associated environmental pollutants might significantly affect the thyroid function. Environmental surveillance, biomonitoring and environmental cleanup are emphasized. Future research on the mechanisms of the observed toxicological effects on thyroid hormones and targeted protection of pregnant women and their offspring is suggested.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Thyroid Hormone Levels in Mothers and Cord Blood at Delivery in Crude Oil Producing Community in Delta State, Nigeria

Emokpae,

Ogana

2024

Explor Res Hypothesis Med

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“…Dietary exposure to PAHs contaminated food has been associated with a wide range of multiple organ and systemic pathogenesis predominantly cancers of various organs. As lipophilic compounds, PAHs can transverse/cross-cell membranes via passive diffusion upon their ingestion or inhalation and accumulate in different organs [ 6 ]. Previous experimental studies on mammalian cells have shown evidence that the metabolic transformation of PAHs generates free radical molecules which may result in antioxidant depletion, peroxidation of lipids, protein modifications, and oxidative DNA damage [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Impacts of PAH accumulation on reproductive hormones, indices of oxidative stress and BPDE-albumin adduct in women with recurrent pregnancy loss

El-Sikaily,

Helal,

Nsonwu-Anyanwu

et al. 2023

Toxicol Res.

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Chronic exposure to Poly aromatic hydrocarbons (PAHs) may be associated with adverse pregnancy outcomes. Disruption of hormonal and redox balance by toxic PAH metabolites may interfere with successful pregnancy leading to miscarriage. The association of exposure to PAH contaminated mussel via the dietary route with perturbations in reproductive hormones, biomarkers of oxidative stress, and PAH metabolites were assessed in women with recurrent pregnancy loss (RPL). Furthermore, an analysis of the concentration of PAHs in environmentally relevant bivalve animals was performed to preliminary get insights into the levels of these pollutants in the environment. Seventy-six women (20–35 years) were categorized into 18 fertile women without RPL (control), and Groups I, II, and III comprising 24, 18, and 16 women with RPL (2, 3, and > 3 abortions respectively) were studied. Whole blood samples were collected for the estimation of malondialdehyde (MDA), catalase, reduced glutathione (GSH), glutathione-S-transferase (GST), progesterone (P4), follicle-stimulating hormone (FSH), benzo[a]pyren-7,8-dihydrodiol-9,10-epoxide-albumin adduct (BPDE-albumin) and urine for α-naphthol and β-naphthol. Two species of mussel Donax trunculus and Andar aduloii samples were collected for the estimation of 16 priority PAHs. The concentration of PAHs exceeding the maximum limits was observed in the two species of mussels studied. Higher levels of BPDE-albumin, MDA, GST, α and β-naphthol and lower GSH, catalase, FSH, and P4 were observed in women with RPL (Groups I-III) compared to controls (p = < 0.001). Negative associations were observed between BPDE-albumin and catalase (r = − 0.276, p = 0.036), and GSH (r = − 0.331, p = − 0.011) only in women with RPL. Collectively, our findings indicate a possible association of chronic PAH accumulation with recurrent pregnancy loss in women. Graphical abstract High PAH exposure in pregnant women is associated with 10-epoxide-albumin adduct formation and high MDA levels in their sera. On the other hand, PAH exposure in those women led to a decrease in their GSH, catalase, P4, and FSH sera levels. These findings indicate that PAH exposure can exert different physiological effects in pregnant women leading to a high level of abortion in those women.

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“…Yang et al [16] published meta-analysis of 11 studies on the association between prenatal exposure to polycyclic aromatic hydrocarbons and birth weight. They concluded there is no significant relationship between prenatal exposure to PAHs and birth weight.…”

Section: Introductionmentioning

confidence: 99%

Prenatal Exposure to Polycyclic Aromatic Hydrocarbons and Birth Outcomes

Šrám¹,

Solanský²,

Pastorková³

et al. 2022

Preprint

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Background and objectives: The impact of prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) to birth outcomes as weight, length, head perimeter, placenta weight and Apgar score. Materials and Methods: Two cohorts of children born in the years 2013 and 2014 in Karvina (Northern Moravia, N=144) and Ceske Budejovice (Southern Bohemia, N=198) were studied for the relationship between prenatal exposure to PAHs and growth parameters up to two years of age. PAHs exposure was evaluated according to concentration of benzo[a]pyrene (B[a]P) in polluted air and monohydroxylated PAH metabolites (OH-PAHs) in urine of newborns and their mothers. Data on growth parameters were obtained from pediatric questionnaires up to 24 months. Results: Concentrations of B[a]P were significantly higher in Karvina (p<0.001). OH-PAH metabolites were significantly higher in the mother´s as well as in the newborn’ s urine in Karvina. The length was shorter in newborns in Karvina at birth (p<0.001), but this difference was straightened out during next 3 to 24 months. Birth weight at the delivery did not differ between newborns in Karvina and Ceske Budejovice. Newborns in both locations significantly decreased their weight gain between birth and 3 months after delivery. OH-PAHs metabolites in mother’s or newborn’s urine did not affect birth weight. Top 25% values of concentrations of 2-OH-FLUO, 1-OH-NAP, 2-OH-NAP, 1-OH-PHEN, 2-OH-PHEN, 3-OH-PHEN, 4-OH-PHEN and the sum of all-OH-PAHs higher than median in the newborn´s urine decreased their length. 2-OH-PHEN top 25% of concentrations in the newborn´s urine decreased their head perimeter, 2-OH-FLUO, 1-OH-NAP, 2-OH-NAP, 1-OH-PHEN, 2-OH-PHEN, 3-OH-PHEN, 4-OH-PHEN, 9-OH-PHEN, 1-OH-PYR, and all-OH-PAHs decreased placenta weight; 2-OH-FLUO, 1-OH-NAP, 2-OH-NAP, 1-OH-PHEN, 2-OH-PHEN, 3-OH-PHEN, 4-OH-PHEN, and all-OH-PAHs decreased Apgar 5´. Conclusions: We observed that higher concentration of PAHs determined as OH-PAHs metabolites in newborn´s urine decreased their length, head perimeter, placenta weight, and Apgar 5´, but did not affect birth weight.

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The association between prenatal exposure to polycyclic aromatic hydrocarbons and birth weight: A meta-analysis

Cited by 16 publications

References 46 publications

Thyroid Hormone Levels in Mothers and Cord Blood at Delivery in Crude Oil Producing Community in Delta State, Nigeria

Thyroid Hormone Levels in Mothers and Cord Blood at Delivery in Crude Oil Producing Community in Delta State, Nigeria

Impacts of PAH accumulation on reproductive hormones, indices of oxidative stress and BPDE-albumin adduct in women with recurrent pregnancy loss

Prenatal Exposure to Polycyclic Aromatic Hydrocarbons and Birth Outcomes

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