The association between prenatal exposure to organochlorine pesticides and thyroid hormone levels in newborns in Yancheng, China

Li, Chengcheng; Cheng, Yang; Tang, Quan; Lin, Shaobin; Li, Yonghong; Hu, Xiaojian; Nian, Juan; Gu, Heng; Lu, Yifu; Tang, Hong; Dai, Shougui; Zhang, Hongqun; Jin, Cong; Zhang, Hai‐Jing; Jin, Yuanyuan; Jin, Yinlong

doi:10.1016/j.envres.2013.12.009

Cited by 59 publications

(32 citation statements)

References 17 publications

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“…Pesticides can also vaporize into the air and affect the larger community. In Guangzho, China an urban community was exposed to airborne concentrations of chlorpyrifos and pyrethroids, peaking during summer and fall seasons which corresponds to the application patterns and exposure duration (Li et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Ergonomic and health assessment of farmers’ multi-pesticide exposure

Lu¹

2017

Ergonomics South Afr

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Objective. This was a cross-sectional study conducted among 534 farmers in the largest vegetable -producing area in the northern part of the Philippines. This study assessed the ergonomic risk factors, and occupational health and safety conditions of farmers' multi-pesticide exposures.Methods. Methods consisted of interviewer-guided survey questionnaires on pesticide use among farmers, agricultural safety risk factors associated with pesticide exposure and physical health assessments of farmers. The subjects were selected using multistage random sampling, yielding a total of 534 farmers.Results. The majority of the study population were males (53.3%), with a mean age of 47 years old. Occupational exposure accounted for major exposure (84.8%). Farmers often complained of a headache (69.4%) and dizziness (41.0%) after their exposure to pesticides. As for common respiratory symptoms, farmers often complained of coughing (39.4%), difficulty with breathing (15.6%), breathlessness (14.9%) and having pulmonary secretions (13.3%). Farmers reported pesticide spills on their body parts while spraying (79%), and 49 % complained of getting sick because of work. Of those who got ill, 69.8% did not receive any medical attention. Of the farmers, 40.9% were diagnosed with abnormal physical examination findings, and less than 10% had abnormal laboratory results. Conclusion.The results showed that farmers were exposed to pesticides while undertaking their agricultural work and that certain occupationally-related health symptoms manifested. This underscores the need to improve protection measures to reduce the exposure of the farmers to pesticides.

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Section: Discussionmentioning

confidence: 99%

Ergonomic and health assessment of farmers’ multi-pesticide exposure

Lu¹

2017

Ergonomics South Afr

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“…Prevalence of type 2 diabetes and exposure to persistent organic pollutants has been established (Airaksinen et al ., 2011). Recent studies on organochlorine pesticides have shown that β-HCH, HCB and DDT residues bio-accumulate in maternal and cord sera and from maternal blood they can be transferred through the placenta and affect thyroid hormone levels in the newborn (Li et al ., 2014). OC pesticides have been suggested to affect the thyroid system through gender-specific mechanisms; the extent of the effect may differ among compounds (Freire et al ., 2013).…”

Section: Effect In Humansmentioning

confidence: 99%

Review Article. Organochlorine pesticides, their toxic effects on living organisms and their fate in the environment

Ravindran

Megha

Puthur

2016

Interdisciplinary Toxicology

853

359

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Organochlorine (OC) pesticides are synthetic pesticides widely used all over the world. They belong to the group of chlorinated hydrocarbon derivatives, which have vast application in the chemical industry and in agriculture. These compounds are known for their high toxicity, slow degradation and bioaccumulation. Even though many of the compounds which belong to OC were banned in developed countries, the use of these agents has been rising. This concerns particularly abuse of these chemicals which is in practice across the continents. Though pesticides have been developed with the concept of target organism toxicity, often non-target species are affected badly by their application. The purpose of this review is to list the major classes of pesticides, to understand organochlorine pesticides based on their activity and persistence, and also to understand their biochemical toxicity.

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“…Therefore, women and developing fetuses are subjected to greater risk due to OCP exposure, and OCP exposure may be responsible for antagonistic effect on growth and development of the fetus. One of the studies done in women population of Bangladesh from non-endemic area has shown higher concentration of p,p′-DDT and its metabolite p,p′-DDE (median values 349 and 1645 ng/g lipid, respectively) in (Li et al 2014). …”

Section: Discussionmentioning

confidence: 97%

Organochlorine pesticide levels in maternal blood and placental tissue with reference to preterm birth: a recent trend in North Indian population

Tyagi

Garg

Mustafa

et al. 2015

Environ Monit Assess

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Organochlorine pesticides (OCPs) have been widely used in public health and agriculture programs in developed as well as developing countries, including India. Being xenoestrogenic in nature, OCPs may act as endocrine disruptors leading to preterm birth (PTB) through disturbance of normal estrogen-progesterone ratio. PTB is the leading cause of neonatal deaths worldwide. Therefore, the present study is aimed to determine the extent to which persistent environmental chemicals may accumulate in pregnant women and placenta and ascertain possible associations between exposure level and period of gestation (POG), baby weight, and/or placental weight in PTB cases. Maternal blood and placenta samples of PTB cases (n = 50) and subjects of term delivery as controls (n = 50) were collected. OCP residue levels were estimated by the gas chromatography system equipped with an electron capture detector. Significantly higher levels of α-hexachlorocyclohexane (α-HCH), β-hexachlorocyclohexane (β-HCH), dichlorodiphenyldichloroethane (DDD), and dichlorodiphenyldichloroethylene (DDE) were found in maternal blood of PTB cases as compared to control. Significantly higher levels of DDE and dichlorodiphenyltrichloroethane (DDT) were also found in placental tissue of PTB cases as compared to control group. There was a statistically significant negative correlation between maternal blood level of α-HCH and birth-weight (r = -0.299) and POG (r = -0.234). γ-Hexachlorocyclohexane (γ-HCH) and dieldrin had a negative correlation with placental weight (r = -0.401 and -0.256, respectively), and DDE and β-HCH had a negative correlation with POG (r = -0.251 and -0.229, respectively). The presence of OCPs in maternal blood and placental tissue represents prenatal exposure hazard for fetuses due to chronic bioaccumulation and poor elimination with possible deleterious effect on health.

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The association between prenatal exposure to organochlorine pesticides and thyroid hormone levels in newborns in Yancheng, China

Cited by 59 publications

References 17 publications

Ergonomic and health assessment of farmers’ multi-pesticide exposure

Ergonomic and health assessment of farmers’ multi-pesticide exposure

Review Article. Organochlorine pesticides, their toxic effects on living organisms and their fate in the environment

Organochlorine pesticide levels in maternal blood and placental tissue with reference to preterm birth: a recent trend in North Indian population

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