The association between prenatal exposure to perfluoroalkyl substances and childhood neurodevelopment

Spratlen, Miranda J.; Perera, Frederica P.; Lederman, Sally Ann; Rauh, Virginia; Robinson, Morgan; Kannan, Kurunthachalam; Trasande, Leonardo; Herbstman, Julie B.

doi:10.1016/j.envpol.2020.114444

Cited by 58 publications

(36 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Spratlen et al found evidence suggesting sex-specific associations between prenatal exposure to PFASs and childhood neurodevelopment; specifically, higher prenatal PFAS exposure may be associated with higher scores for some cognition for females but not for males. Spratlen, et al, noted that these findings should be interpreted with caution due to limited data and statistical tests and citing different results from other studies [48].…”

Section: Prenatal Maternal Infantmentioning

confidence: 85%

“…Although the emerging literature on prenatal PFAS exposure and neurodevelopment is still in its nascence and so inconsistent, a study from 2020 show associations between prenatal exposure to PFAS and neurodevelopment [48]. Studies examining prenatal PFAS exposure and IQ and other childhood cognitive outcomes have had inconsistent results, some adverse on IQ while others were positive.…”

Section: Prenatal Maternal Infantmentioning

confidence: 99%

See 1 more Smart Citation

Per and polyfluoroalkyl substances scientific literature review: water exposure, impact on human health, and implications for regulatory reform

Chohan

Petaway

Rivera-Diaz

et al. 2020

Reviews on Environmental Health

View full text Add to dashboard Cite

Among other emerging contaminants in water, per and polyfluoroalkyl substances (PFASs) have garnered international attention from the scientific community on a global scale. Some countries, such as the United States, have found that PFASs are present in humans on a wide scale. Although two PFASs have been widely studied-Perfluorooctanoic acid and Perfluorooctanesulfonic acid-many more PFASs are being created by industry and are either not known, not studied, or both. The objective of this literature review on PFASs is to give an overview of the information available about PFASs related to human exposure. The information from this literature review on the exposure of humans to PFASs through drinking water and the lack of many conventional drinking water treatment systems' ability to remove PFASs (particularly short-chain PFASs) suggests that current regulatory limits are insufficient to adequately protect humans. This is especially true for particularly vulnerable populations such as infants, young children, and developing children (pubescent). The gaps in the current knowledge and in current regulatory approaches could have long-term effects on human health.

show abstract

Section: Prenatal Maternal Infantmentioning

confidence: 85%

Section: Prenatal Maternal Infantmentioning

confidence: 99%

Per and polyfluoroalkyl substances scientific literature review: water exposure, impact on human health, and implications for regulatory reform

Chohan

Petaway

Rivera-Diaz

et al. 2020

Reviews on Environmental Health

View full text Add to dashboard Cite

show abstract

“…Most studies evaluated health effects (primarily neurodevelopment and cognitive effects) from prenatal exposures to chemicals and persistent organic pollutants. Prenatal chemical exposures included polycyclic aromatic hydrocarbons (PAHs) [ 81 , 82 , 83 ], perfluoroalkyl substances (PFAS) [ 84 , 85 , 86 ], mercury [ 80 ], and polybrominated diphenyl ethers (PBDEs) [ 87 , 88 ].…”

Section: Research Portfoliomentioning

confidence: 99%

“…Spratlen et al (2018) found 13% higher perfluorooctanoic acid (PFOA) concentrations in pregnant women living or working within 2 miles of the WTC site compared to the reference group (geometric mean ratio, GMR = 1.13, 95% CI: 1.01, 1.27) [ 86 ]. Exposure to several PFAS prenatally have been associated with higher lipid levels and triglycerides in maternal and cord blood [ 90 ].…”

Section: Research Portfoliomentioning

confidence: 99%

“…Studies evaluating the relationship between prenatal PFAS exposure and cognition in non-WTC populations have yielded inconsistent findings, showing there is a complex relationship between PFAS and neurodevelopment [ 93 , 94 , 95 , 96 , 97 , 98 , 99 ]. A study of 302 mother–child dyads enrolled in a WTC birth cohort found that overall increases in PFAS concentrations were associated with higher Mental Development Index (MDI) scores (higher scores indicating better development), which assesses early cognition and language development by evaluating sensory-perception, knowledge, memory, problem solving and early language [ 86 ]. Furthermore, sex-specific relationships between PFAS and cognition were found.…”

Section: Research Portfoliomentioning

confidence: 99%

See 1 more Smart Citation

World Trade Center Health Program: First Decade of Research

Santiago-Colón

Daniels

Reissman

et al. 2020

IJERPH

View full text Add to dashboard Cite

The terrorist attacks on 11 September 2001 placed nearly a half million people at increased risk of adverse health. Health effects research began shortly after and continues today, now mostly as a coordinated effort under the federally mandated World Trade Center (WTC) Health Program (WTCHP). Established in 2011, the WTCHP provides medical monitoring and treatment of covered health conditions for responders and survivors and maintains a research program aimed to improve the care and well-being of the affected population. By 2020, funds in excess of USD 127 M had been awarded for health effects research. This review describes research findings and provides an overview of the WTCHP and its future directions. The literature was systematically searched for relevant articles published from 11 September 2001 through 30 June 2020. Synthesis was limited to broad categories of mental health, cancer, respiratory disease, vulnerable populations, and emerging conditions. In total, 944 WTC articles were published, including peer-reviewed articles funded by the WTCHP (n = 291) and other sources. Research has focused on characterizing the burden and etiology of WTC-related health conditions. As the program moves forward, translational research that directly enhances the care of individuals with chronic mental and physical health conditions is needed.

show abstract