The association between prenatal concentrations of polybrominated diphenyl ether and child cognitive and psychomotor function

Solazzo, G.; Wu, Haotian; Laue, Hannah E.; Brennan, Kasey; Knox, Julia; Gillet, Virginie; Bovin, Amélie; Abdelouahab, Nadia; Posner, Jonathan; Raffanello, Elizabeth; Pieper, Sarah; Bowman, Frederick O.; Drake, Daniel; Baccarelli, Andrea A.; Takser, Larissa

doi:10.1097/ee9.0000000000000156

Cited by 4 publications

(6 citation statements)

References 47 publications

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“…In the five other studies that studied association between prenatal maternal levels of PBDEs and attention or hyperactivity scores, null associations were reported (Adgent et al., 2014 ; Gascon et al., 2011 ; Julvez et al., 2021 ; Sagiv et al., 2015 ; Solazzo et al., 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…Twelve publications assessed inattention or hyperactivity subscales through a range of tools, including the CBCL, Conners DSM‐IV, CPT, BASC, SDQ and TEA‐Ch (Gascon et al., 2011 ; Kiciński et al., 2012 ; Eskenazi et al., 2013 ; Adgent et al., 2014 ; Chen, Yolton, et al., 2014 ; Gump et al., 2014 ; Cowell et al., 2015 ; Julvez et al., 2021 ; Ji et al., 2019 ; Sagiv et al., 2015 ; Solazzo et al., 2021 ; Vuong, Yolton, Xie, et al., 2017 ). Four of these studies observed statistically significant associations related to prenatal PBDE levels: the CHAMACOS cohort reported an association between Sum PBDEs and increased CBCL‐attention problems and DSM‐IV‐inattention problems at 5 and 7 years (Eskenazi et al., 2013 ); The HOME cohort reported an association between BDE‐47 and increased BASC‐hyperactivity problems (Chen, Yolton, et al., 2014 ); Ji et al.…”

Section: Discussionmentioning

confidence: 99%

“…BDE-99 was assessed in all studies and two statistically significant associations were observed for the IQ components at two different timepoints (2 years and 6-8 years) but with opposite effects (Herbstman et al, 2010;Solazzo et al, 2021).…”

Section: Cognitive Functionmentioning

confidence: 99%

“…Twelve publications assessed inattention or hyperactivity subscales through a range of tools, including the CBCL, Conners DSM-IV, CPT, BASC, SDQ and TEA-Ch (Gascon et al, 2011;Kiciński et al, 2012;Eskenazi et al, 2013;Adgent et al, 2014;Chen, Yolton, et al, 2014;Gump et al, 2014;Cowell et al, 2015;Julvez et al, 2021;Ji et al, 2019;Sagiv et al, 2015;Solazzo et al, 2021;. Four of these studies observed statistically significant associations related to prenatal PBDE levels:…”

Section: Adhd Hyperactivity Attentionmentioning

confidence: 99%

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Update of the risk assessment of polybrominated diphenyl ethers (PBDEs) in food

Schrenk,

Bignami,

Bodin

et al. 2024

EFS2

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The European Commission asked EFSA to update its 2011 risk assessment on polybrominated diphenyl ethers (PBDEs) in food, focusing on 10 congeners: BDE‐28, ‐47, ‐49, ‐99, ‐100, ‐138, ‐153, ‐154, ‐183 and ‑209. The CONTAM Panel concluded that the neurodevelopmental effects on behaviour and reproductive/developmental effects are the critical effects in rodent studies. For four congeners (BDE‐47, ‐99, ‐153, ‐209) the Panel derived Reference Points, i.e. benchmark doses and corresponding lower 95% confidence limits (BMDLs), for endpoint‐specific benchmark responses. Since repeated exposure to PBDEs results in accumulation of these chemicals in the body, the Panel estimated the body burden at the BMDL in rodents, and the chronic intake that would lead to the same body burden in humans. For the remaining six congeners no studies were available to identify Reference Points. The Panel concluded that there is scientific basis for inclusion of all 10 congeners in a common assessment group and performed a combined risk assessment. The Panel concluded that the combined margin of exposure (MOET) approach was the most appropriate risk metric and applied a tiered approach to the risk characterisation. Over 84,000 analytical results for the 10 congeners in food were used to estimate the exposure across dietary surveys and age groups of the European population. The most important contributors to the chronic dietary Lower Bound exposure to PBDEs were meat and meat products and fish and seafood. Taking into account the uncertainties affecting the assessment, the Panel concluded that it is likely that current dietary exposure to PBDEs in the European population raises a health concern.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Cognitive Functionmentioning

confidence: 99%

Section: Adhd Hyperactivity Attentionmentioning

confidence: 99%

See 2 more Smart Citations

Update of the risk assessment of polybrominated diphenyl ethers (PBDEs) in food

Schrenk,

Bignami,

Bodin

et al. 2024

EFS2

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“…Acetaminophen-pathway interactions in association with neurodevelopment. References [ 61 , 62 , 63 , 64 ] are cited in the supplementary materials…”

mentioning

confidence: 99%

In Utero Exposure to Caffeine and Acetaminophen, the Gut Microbiome, and Neurodevelopmental Outcomes: A Prospective Birth Cohort Study

Laue

Shen

Bloomquist

et al. 2022

IJERPH

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Pregnant individuals are exposed to acetaminophen and caffeine, but it is unknown how these exposures interact with the developing gut microbiome. We aimed to determine whether acetaminophen and/or caffeine relate to the childhood gut microbiome and whether features of the gut microbiome alter the relationship between acetaminophen/caffeine and neurodevelopment. Forty-nine and 85 participants provided meconium and stool samples at 6–7, respectively, for exposure and microbiome assessment. Fecal acetaminophen and caffeine concentrations were quantified, and fecal DNA underwent metagenomic sequencing. Caregivers and study staff assessed the participants’ motor and cognitive development using standardized scales. Prenatal exposures had stronger associations with the childhood microbiome than concurrent exposures. Prenatal acetaminophen exposure was associated with a trend of lower gut bacterial diversity in childhood [β = −0.17 Shannon Index, 95% CI: (−0.31, −0.04)] and was marginally associated with differences in the relative abundances of features of the gut microbiome at the phylum (Firmicutes, Actinobacteria) and gene pathway levels. Among the participants with a higher relative abundance of Proteobacteria, prenatal exposure to acetaminophen and caffeine was associated with lower scores on WISC-IV subscales. Acetaminophen during bacterial colonization of the naïve gut is associated with lasting alterations in childhood microbiome composition. Future studies may inform our understanding of downstream health effects.

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