The association between polypharmacy and malnutrition(risk) in older people: A systematic review

Kok, Wilhelmina; Haverkort, Elizabeth B.; Algra, Y.A.; Mollema, Jürgen; Hollaar, V.R.Y.; Naumann, Elke; Schueren, M.A.E. de van der; Jerković-Ćosić, Katarina

doi:10.1016/j.clnesp.2022.03.007

Cited by 24 publications

(16 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Additionally, the long-term use of multiple drugs may also cause loss of appetite, reduction in food intake and compromise the absorption of essential vitamins and minerals [ 71 , 72 ]. A recent systematic review reported a statistically significant association between polypharmacy and malnutrition in older adults [ 73 ].…”

Section: Factors Affecting Optimal Dietary Intake In Older Adultsmentioning

confidence: 99%

Protein Intake and Oral Health in Older Adults—A Narrative Review

et al. 2022

View full text Add to dashboard Cite

Oral health is vital to general health and well-being for all ages, and as with other chronic conditions, oral health problems increase with age. There is a bi-directional link between nutrition and oral health, in that nutrition affects the health of oral tissues and saliva, and the health of the mouth may affect the foods consumed. Evidence suggests that a healthy diet generally has a positive impact on oral health in older adults. Although studies examining the direct link between oral health and protein intake in older adults are limited, some have explored the relationship via malnutrition, which is also prevalent among older adults. Protein–energy malnutrition (PEM) may be associated with poor oral health, dental caries, enamel hypoplasia, and salivary gland atrophy. This narrative review presents the theoretical evidence on the impact of dietary protein and amino acid composition on oral health, and their combined impact on overall health in older adults.

show abstract

Section: Factors Affecting Optimal Dietary Intake In Older Adultsmentioning

confidence: 99%

Protein Intake and Oral Health in Older Adults—A Narrative Review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Older adults are generally likely to have multimorbidity (defined as having two or more chronic diseases and conditions), which tends to increase the number of medications they take. Polypharmacy, generally defined as the use of five or more medications, [1] is associated with problems, including drug-drug interactions, [2] falls, [3] worsening of cognitive impairment, [4] malnutrition, [5] and increased risks of hospitalization and mortality. [6,7] Moreover, polypharmacy is associated with frailty [8] and the risk of being certified as requiring long-term care.…”

Section: Introductionmentioning

confidence: 99%

Changes in chronic disease medications after admission to a Geriatric Health Services Facility: A multi-center prospective cohort study

Maruoka,

Hamada,

Hattori

et al. 2023

Medicine

View full text Add to dashboard Cite

Older adults often receive polypharmacy, including some medications for chronic diseases. Nutritional management after admission to a nursing home may enable to deprescribe some chronic disease medications. This study aimed to investigate the status of deprescribing of chronic disease medications among nursing home residents, and to assess the appropriateness based on changes of laboratory test values and nutritional status. A multi-center prospective cohort study was conducted in 6 Geriatric Health Services Facilities, a major type of nursing homes in Japan. Newly admitted residents aged ≥ 65 years who took ≥1 medication for hypertension, diabetes, or dyslipidemia at admission were recruited. Participants who stayed for 3 months were included in the analysis. Medications at admission and 3 months after admission and situations for deprescribing were investigated. Changes in body mass index, blood pressure, laboratory tests (e.g., cholesterol and hemoglobin A1c levels), energy intake, and International Classification of Functioning, Disability and Health staging were evaluated. Sixty-nine participants (68% female, 62% aged ≥ 85 years) were included. At admission, 60 participants had medications for hypertension, 29 for dyslipidemia, and 13 for diabetes. Those receiving lipid-modifying drugs (mainly statins) decreased from 29 to 21 (72%; P = .008), since their cholesterol levels was within the normal range or was low at admission, and they had no history of cardiovascular events. However, there were no statistically significant changes in the frequencies of antihypertensive drugs (60 to 55; 92%; P = .063) or antidiabetic drugs (13 to 12; 92%; P = 1.000). During the 3-month observation, body mass index and diastolic blood pressure decreased, while energy intake and serum albumin level increased. Nutritional management after admission to a ROKEN may facilitate appropriate deprescribing of lipid-modifying drugs, by offseting the effects of discontinuation of these drugs.

show abstract

“…MetS patients commonly develop more than one symptom. Hence, the deleterious effects of polypharmacy are frequently observed in them 3 . Therefore, researchers are still exploring an effective therapy that could simultaneously alleviate multiple MetS components.…”

Section: Introductionmentioning

confidence: 99%

Mesenchymal stem cell‐derived extracellular vesicles for metabolic syndrome therapy: Assessing efficacy with nuclear magnetic resonance spectroscopy

Ling,

Govindaraju,

Lokanathan

et al. 2023

Cell Biochemistry & Function

View full text Add to dashboard Cite

Metabolic syndrome (MetS) represents a cluster of metabolic abnormalities. The prevalence of MetS has surged, transforming it into a pressing public health concern that could potentially affect around 20%–25% of the global population. As MetS continues its ascent, diverse interventions, pharmacological, nonpharmacological and combined have been deployed. Yet, a comprehensive remedy that fully eradicates MetS symptoms remains elusive, compounded by the risks of polypharmacy's emergence. Acknowledging the imperative to grasp MetS's intricate pathologies, deeper insights for future research and therapy optimisation become paramount. Conventional treatments often target specific syndrome elements. However, a novel approach emerges in mesenchymal stem cell‐derived extracellular vesicles (MSC‐EVs) therapy, promising a holistic shift. MSC‐EVs, tiny membranous vesicles secreted by mesenchymal stem cells, have garnered immense attention for their multifaceted bioactivity and regenerative potential. Their ability to modulate inflammation, enhance tissue repair and regulate metabolic pathways has prompted researchers to explore their therapeutic application in MetS. This review primarily aims to provide an overview of how MSC‐EVs therapy can improve metabolic parameters in subjects with MetS disease and also introduce the usefulness of NMR spectroscopy in assessing the efficacy of MSC‐EVs therapy for treating MetS.

show abstract

The association between polypharmacy and malnutrition(risk) in older people: A systematic review

Cited by 24 publications

References 57 publications

Protein Intake and Oral Health in Older Adults—A Narrative Review

Protein Intake and Oral Health in Older Adults—A Narrative Review

Changes in chronic disease medications after admission to a Geriatric Health Services Facility: A multi-center prospective cohort study

Mesenchymal stem cell‐derived extracellular vesicles for metabolic syndrome therapy: Assessing efficacy with nuclear magnetic resonance spectroscopy

Contact Info

Product

Resources

About