The association between plasma selenium and chronic kidney disease related to lead, cadmium and arsenic exposure in a Taiwanese population

Wu, Chih-Yin; Wong, Chu‐Kwan; Chung, Chi Jung; Wu, Mei Yi; Huang, Ya; Ao, Pui Lam; Lin, Yuh Feng; Lin, Ying; Shiue, Horng Sheng; Su, Chien Tien; Chen, Hsi Hsien; Hsueh, Yu Mei

doi:10.1016/j.jhazmat.2019.04.082

Cited by 80 publications

(68 citation statements)

References 64 publications

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“…The kidney is highly vulnerable to damage caused by ROS, which are involved in the pathogenic mechanism of conditions. Arsenic induces oxidative stress in the kidney and may lead to dysfunction of renal tubular epithelial cells [19]. Furthermore, Zhao et al [30] investigated the influence of As on inflammation, differentiation of diverse T cell subsets, and the phenotypic molecules and functions of dendritic cells (DCs) [30].…”

Section: Discussionmentioning

confidence: 99%

“…Immunity is a matter of supreme importance in renal transplant recipients even if it needs to be lowered. In contrast, selenium is believed to be an antioxidant nutrient that is important in the biological defense against organs/tissues damage via induction of oxidative stress [ 19 ]. It is believed that selenium in the kidney may decrease the levels of the inflammatory cytokines (induced, among others, by heavy metals) [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, selenium is believed to be an antioxidant nutrient that is important in the biological defense against organs/tissues damage via induction of oxidative stress [ 19 ]. It is believed that selenium in the kidney may decrease the levels of the inflammatory cytokines (induced, among others, by heavy metals) [ 19 ]. Current data regarding MMF are controversial [ 2 , 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, Se is a trace element that plays a significant role in the functions of the immune system and is involved, next to kidneys, in detoxification process [15]. The kidney is responsible for maintaining the homeostasis of numerous trace elements [19,20]. It has been documented that patients with chronic kidney disease exhibit lower plasma selenium concentration compared with healthy ones [19,21].…”

Section: Introductionmentioning

confidence: 99%

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Arsenic and Selenium Profile in Erythrocytes of Renal Transplant Recipients

Wilk

Wiszniewska

2019

Biol Trace Elem Res

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Arsenic and selenium elements play extremely important roles in organisms. Too high As concentration in blood may lead to functional disorders within organs, including cancer. Arsenic is designated as a Group 1 human carcinogen by the International Agency for Research on Cancer that has established causal role of arsenic in cancers of the urinary bladder, lung, and skin in humans. In contrast, Se is believed to be the antioxidant trace element that is important in the biological defense against oxidative damage. We tested the hypothesis that immunosuppressive treatment based on mycophenolate mofetil (MMF), that is one of the most commonly used drug by renal transplant recipients, affects arsenic and selenium concentration in erythrocytes of renal transplant recipients. Current research was undertaken due to the fact that there are few studies on the concentration of chemical elements in the erythrocytes in kidney patients receiving immunosuppressive drugs. Monitoring of the concentration of chemical elements in the blood in patients who underwent kidney transplantation could be helpful, since chemical elements play an important role in many biological processes and it seems to be crucial in the prevention of cancer to which renal transplant recipients are more often exposed.The material consisted of blood from 115 renal transplant recipients of the the city of Szczecin in northwestern Poland. Arsenic and selenium levels in erythrocytes were quantified by inductively coupled mass spectroscopy.Men MMF+ had significantly higher As concentration than men MMF−. Se concentration was significantly higher in younger patients compared with older patients. The patients with lower creatinine level who used MMF had significantly higher As than MMF− patients. Patients whose therapy was based on MMF, cyclosporine A and glucocorticosteroids exhibited significantly higher concentration of As compared with patients whose regimen was based on MMF, tacrolimus, and glucocorticosteroids. This is the first study that demonstrates that regimen based on mycophenolate mofetil affects As and Se concentrations in erythrocytes in renal transplant recipients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Arsenic and Selenium Profile in Erythrocytes of Renal Transplant Recipients

Wilk

Wiszniewska

2019

Biol Trace Elem Res

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“…Cadmium is a very toxic heavy metal and is widely used in electroplating, coating and metallurgy industries [ 2 ]. Cadmium can enter the body through respiratory and digestive systems, endangering human health [ 3 ]. Various diseases such as emphysema, kidney damage, diabetes, cardiovascular disorders and bone malformations are associated with cadmium ion hazards [ 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Optimization of Cadmium Adsorption by Magnetic Graphene Oxide Using a Fractional Factorial Design

Wang

Zhou

et al. 2020

IJERPH

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Graphene materials have attracted increasing interest in water remediation. In this study, magnetic graphene oxide (MGO) was prepared through the modified Hummers method and the adsorption behaviors of cadmium were investigated. Firstly, the sorption kinetics, isotherms, as well as the effects of pH were investigated. Then, fractional factorial design (FFD) was used to optimize the effects of pH, temperature, time, initial concentration of cadmium ion and NaCl on cadmium adsorption. The results indicate that MGO could effectively remove cadmium ions from an aqueous solution and the sorption data could be described well by pseudo-second-order and Freundlich models, showing that the adsorption rate of cadmium ions on MGO is multilayer adsorption and dominated by the chemical adsorption. According to the FFD results, the maximum adsorption capacity of cadmium ions was 13.169 mg/g under the optimum condition of pH value 8, 45 °C, contact time 60 min, initial cadmium concentration of 70 mg/L and NaCl concentration of 100 mg/L. Higher levels of the pH value, temperature and initial cadmium concentration are beneficial to the adsorption process. These results are important for estimating and optimizing the removal of metal ions by MGO composite.

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