The association between PFOA, PFOS and serum lipid levels in adolescents

Per- and polyfluorinated substances (PFASs): Environmental challenges

“…A "Navigation Guide" review of the available human and non-human evidence concluded similarly that developmental exposure to PFOA adversely affects fetal growth in mammals [333]. Serum PFOA and PFOS levels were positively associated with hyperuricemia [311] and dyslipidemia [223] in children and adolescents, even at the low exposure levels of the US general population.…”

“…PFAS exposure has been consistently associated with lipid and carbohydrate metabolism disorders and elevated serum cholesterol level [221][222][223].…”

Prenatal exposures to perfluoroalkyl acids and serum lipids at ages 7 and 15 in females

“…Exposure to perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) has been associated with higher serum lipid concentrations in children and adolescents (Frisbee et al, 2010;Geiger et al, 2014), adults (Eriksen et al, 2013;Nelson et al, 2010;Steenland et al, 2009), and pregnant women (Starling et al, 2014). Current evidence on the influence of PFAAs on serum lipid concentrations in humans originates from cross-sectional epidemiologic studies, thus causal inference is limited.…”

Pediatric Exposures to Persistent Environmental Chemicals

“…15 Another study by Geiger et al confirmed the associations among children using nationally representative US data, showing an overall positive, significant association between both PFOA and PFOS, and total cholesterol and LDL-C. 16 Geiger et al also examined associations between PFCs and serum uric acid levels and results indicated a strong, significant relationship independent even after complex multivariate adjustment. 17 Finally, a cross-sectional study by Hoffman et al 18 found a modest association between PFOA (OR 1.12; 95% confidence interval [CI]: 1.01-1.23) and PFOS (OR 1.03; 95% CI: 1.01-1.05) and attention deficit hyperactivity disorder among children (n=571).…”