The association between periodontitis and interleukin-6 genetic polymorphism -174 G/C: A meta-analysis

Zhao, Bo; Li, Ronghua

doi:10.1016/j.archoralbio.2018.08.007

Cited by 12 publications

(13 citation statements)

References 41 publications

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“…15,16 The role of IL6 was supported also by meta-analysis of previous publications. 17,18 Four recent meta-analysis reached similar conclusion supporting IL10 polymorphisms as possible biomarkers for PD. 19–22…”

Section: Discussionmentioning

confidence: 70%

Evaluation of IL6, IL10 and VDR alleles distribution in an Italian large sample of subjects affected by chronic periodontal disease

Scapoli

Mucchi²,

Nota

et al. 2019

Int J Immunopathol Pharmacol

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In recent decades, the role played by the immune response to bacteria in the pathogenesis of chronic periodontal disease (PD) has long been studied. Although from the clinical point of view, adequate oral hygiene is essential to ensure a satisfactory response of the host to infections, modulation of the reaction of immune system could be influenced by genetic factors. The aim of the present study was to investigate the distribution of alleles of polymorphisms relevant for chronic periodontitis in a sample of adult subjects affected by chronic PD. The present study was conducted with sample collected in Italian private practice offices from January 2013 to December 2017. The sample included 744 adult patients diagnosed with chronic periodontitis. The inclusion criteria were as follows: age > 18 years, diagnosis of chronic PD. The diagnosis of chronic periodontitis was based on the criteria established by the American Academy of Periodontology. No significant difference in allele distribution among patients from different Italian regions was found. Results, supporting absence of population heterogeneity for the investigated polymorphisms in Italy, suggest similar effect in periodontitis etiology.

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Section: Discussionmentioning

confidence: 70%

Evaluation of IL6, IL10 and VDR alleles distribution in an Italian large sample of subjects affected by chronic periodontal disease

Scapoli

Mucchi²,

Nota

et al. 2019

Int J Immunopathol Pharmacol

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“…60 (95% CI = 0.38-0.97, P = .04), respectively. 17 In another meta-analysis, for Brazilian and for Caucasian populations, the GG genotype played as a risk factor to periodontitis. 18 In addition, the rs1800795 SNP was already associated with T2DM, 73,74 besides obesity 75 and lots of types of cancer.…”

Section: Discussionmentioning

confidence: 99%

“…These data appear to indicate that the rs1800795 in the IL6 promoter could modulate the IL‐6 expression in periodontal tissues and carriers of the variant allele could be protected from periodontal diseases, including both gingivitis and chronic periodontitis. In a meta‐analysis including 18 case‐control studies comprising 1616 periodontitis cases and 1511 controls suggested that the rs1800795 SNP in the IL6 gene may be associated a protection against to periodontitis, since the CC vs. GG inheritance model reduced the risk of general and overall periodontitis by 60% (95% CI = 0.25‐0.65, P < .01) and 31% (95% CI = 0.38‐0.97, P = .04), respectively 17 . In another meta‐analysis, for Brazilian and for Caucasian populations, the GG genotype played as a risk factor to periodontitis 18 .…”

Section: Discussionmentioning

confidence: 99%

“…In the last decades, some polymorphisms mainly in genes related to the immune response and bone remodeling have been preferentially chosen in many candidate gene studies. [12][13][14] Indeed, it is notable in the literature that those genes seemed to be like "classically periodontally investigated polymorphisms," which can be evidenced by the development of many meta-analyses [15][16][17][18] in genes such as (a) (−819 C > T) in the IL-10 gene, which encodes the important anti-inflammatory cytokine 19 ; (b) (−889 G > A) in the IL1A gene, which encodes the IL1-1A cytokine facilitating and amplifying the inflammatory response by induction of adhesion molecules to cellular infiltrate and monocyte stimulation with bone resorption 15 ;…”

Section: Introductionmentioning

confidence: 99%

“…In the last decades, some polymorphisms mainly in genes related to the immune response and bone remodeling have been preferentially chosen in many candidate gene studies 12‐14 . Indeed, it is notable in the literature that those genes seemed to be like “classically periodontally investigated polymorphisms,” which can be evidenced by the development of many meta‐analyses 15‐18 in genes such as (a) (−819 C > T) in the IL‐10 gene, which encodes the important anti‐inflammatory cytokine 19 ; (b) (−889 G > A) in the IL1A gene, which encodes the IL1‐1A cytokine facilitating and amplifying the inflammatory response by induction of adhesion molecules to cellular infiltrate and monocyte stimulation with bone resorption 15 ; (c) (+ 3954 G > A) in the IL1B gene which plays an important role as a mediator of various inflammatory responses in periodontitis 20 ; (d) (−590 C > T) in the IL4 gene that encodes a cytokine involved in the process of inflammation 16 ; (e) (−308 G > A) in the Tumor Necrosis Factor Alpha ( TNFA) gene which encodes a pro‐inflammatory cytokine 21 ; (f) (−174 C > G) in the Interleukin‐6 ( IL‐6 ) gene which encodes an important multifunctional cytokine 22 . Bone remodeling results from the balance between osteoblast and osteoclast activity 23 .…”

Section: Introductionmentioning

confidence: 99%

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Genetic polymorphisms in the Interleukins IL1B, IL4, and IL6 are associated with concomitant periodontitis and type 2 diabetes mellitus in Brazilian patients

Cirelli

Nepomuceno

Rios

et al. 2020

J of Periodontal Research

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Objective: To assess whether single nucleotide polymorphisms (SNPs) in the IL10, IL1A, IL1B, IL4, TNFA, IL6, OPG, RANK, and RANKL genes, "classically" related with periodontitis, could be associated with susceptibility to T2DM, and also with both diseases concomitantly. Background: There are common pathogenic mechanisms in type 2 diabetes mellitus (T2DM) and periodontitis, but the knowledge of the genetic aspect of this is limited. In patients affected by concomitant T2DM and periodontitis, whose incidence is increasing, there is scarce information regarding the gene-phenotype association, including whether there are genes able to influence both diseases as comorbidities. Methods: Periodontal clinical parameters and biochemical profile (Insulin, Fasting Glycemia, HbA1c, Triglycerides, Total Cholesterol, HDL-cholesterol, and LDLcholesterol) data were obtained from 894 individuals divided into following three groups: Healthy (H; n = 347), Periodontitis (P; n = 348), and Periodontitis + T2DM (P + T2DM; n = 199). DNA from oral epithelial cells was collected for genotyping. Associations between SNPs and pathologies were tested by multiple logistic regression models, adjusting for age, sex, and smoking habits. We also investigated whether there are sex or smoking effects of each SNP in these phenotypes. Results: The rs1143634-GA (IL1B) SNP showed significantly less likely to develop P + T2DM for all population and mainly for women (adjusted OR = 0.37, 95% CI = 0.16-0.88), while women carrying the rs224320 CT (IL4) were more susceptible to develop P + T2DM (adjusted OR = 1.81, 95% CI = 1.04-3.15). Men carrying the rs1800795-CC (IL6) genotype were less likely to develop T2DM (adjusted OR = 0.12, 95% CI = 0.02-0.70, P = .01). Conclusions: Some SNPs in the IL1B, IL4, and IL6 genes demonstrated sex-influenced association with concomitant periodontitis and T2DM, increasing the evidence of a common genetic component between these diseases and contributing with the understanding of their common pathogenic mechanisms. | 919 CIRELLI Et aL.

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Interleukin-6 gene -174G>C promoter polymorphism reduces the risk of periodontitis in Brazilian populations: A meta-analysis

Mehar

Swarnakar

Lakkakula³

et al. 2021

Journal of Oral Biosciences

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The association between periodontitis and interleukin-6 genetic polymorphism -174 G/C: A meta-analysis

Cited by 12 publications

References 41 publications

Evaluation of IL6, IL10 and VDR alleles distribution in an Italian large sample of subjects affected by chronic periodontal disease

Evaluation of IL6, IL10 and VDR alleles distribution in an Italian large sample of subjects affected by chronic periodontal disease

Genetic polymorphisms in the Interleukins IL1B, IL4, and IL6 are associated with concomitant periodontitis and type 2 diabetes mellitus in Brazilian patients

Interleukin-6 gene -174G>C promoter polymorphism reduces the risk of periodontitis in Brazilian populations: A meta-analysis

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