The association between periodontitis and cardiovascular risks in asymptomatic healthy patients

Donders, H. C. M.; Veth, E. O.; Hof, Arnoud W J van ‘t; Lange, Jan de; Loos, Bruno G.

doi:10.1016/j.ijcrp.2021.200110

Cited by 14 publications

(9 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This dental-practice based clinical intervention study was a 1-year follow-up, of our prospective cross-sectional study as published previously ( 20 ). The study was approved by the Medical Ethics Committee, Isala Academy, Zwolle, the Netherlands (NL43083.075.13) and has been registered in the ISRCTN trial registry with study ID ISRCTN55656827.…”

Section: Methodsmentioning

confidence: 99%

“…We included periodontitis patients and control subjects, between 45 and 69 years of age, without known systemic diseases and with at least 10 teeth. At baseline, all subjects were included in our previously published prospective cross-sectional study ( 20 ). The periodontitis patients received periodontal treatment after the baseline measurements.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

The Effect of Periodontal Treatment on the Reactive Hyperemia Index. A 1-Year Follow-Up Pilot Study

Donders

Veth

Edens

et al. 2022

Front. Cardiovasc. Med.

Self Cite

View full text Add to dashboard Cite

BackgroundPeriodontitis is a chronic multifactorial inflammatory disease of the supportive tissues of the teeth. In more recent years, remarkable epidemiological and pathophysiological associations between periodontitis and cardiovascular disease (CVD) have been presented. Whether or not treatment of periodontitis is valuable for primary or secondary prevention of cardiovascular disease, has not yet been fully established. In this practice-based pilot study we focused on primary prevention of cardiovascular disease, by investigating the effect of periodontal treatment on the earliest detectable stage of CVD; endothelial dysfunction.MethodsOtherwise healthy periodontitis and non-periodontitis participants 45–70 years of age were included in the study. One year after completing periodontal (non-surgical and surgical) treatment of the periodontitis patients and 1 year after inclusion of the controls, all baseline measurements were repeated. Full-mouth examinations were performed by a periodontist to determine their Periodontal Inflamed Surface Area (PISA) score and other dental parameters. To assess the cardiovascular conditions, endothelial function through the reactive hyperemia index (RHI) assessed by the EndoPAT™, and several physical and biochemical parameters were measured.Results21 patients with diagnosed, untreated periodontitis and 21 participants without periodontitis were included in this follow-up study. After periodontal therapy in the periodontitis patients, the PISA reduced significantly. The RHI did not show a significant improvement after treatment of the periodontitis patients (−0.1 ± 0.8, p = 0.524). Similarly, other secondary cardiovascular outcome measurements, hsCRP, total cholesterol, HDL cholesterol, triglycerides, HbA1c, and systolic blood pressure did not improve significantly after periodontal treatment. Controls did not show any significant changes in the RHI, in other CVD parameters and in the PISA after 1-year follow-up.ConclusionIn this practice-based pilot study, periodontal treatment did not improve the endothelial function in otherwise healthy adults with periodontitis. Future studies are needed to be of larger size and could focus on periodontitis patients with co-morbidities to investigate whether periodontal treatment has secondary preventive effect on endothelial function and other CVD parameters.Clinical Trial Registration[www.ClinicalTrials.gov], identifier [ISRCTN55656827].

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

The Effect of Periodontal Treatment on the Reactive Hyperemia Index. A 1-Year Follow-Up Pilot Study

Donders

Veth

Edens

et al. 2022

Front. Cardiovasc. Med.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Progressive alveolar bone loss ultimately leads to loss of teeth, posing negative influences to oral function and aesthetics. The harm of periodontitis exceeds teeth loss, but also involves a higher risk of systematic diseases, such as cardiovascular disease ( Donders et al, 2021 ), oral squamous cell carcinoma ( Hu et al, 2021 ), and rheumatoid arthritis ( Choi and Lee, 2021 ).…”

Section: Msc-exos For Therapeutic Applications In Microbial Diseasesmentioning

confidence: 99%

Mesenchymal Stem Cell-Derived Exosome Therapy of Microbial Diseases: From Bench to Bed

Wu¹,

Jin²,

Ding³

et al. 2022

Front. Microbiol.

View full text Add to dashboard Cite

Microbial diseases are a global health threat, leading to tremendous casualties and economic losses. The strategy to treat microbial diseases falls into two broad categories: pathogen-directed therapy (PDT) and host-directed therapy (HDT). As the typical PDT, antibiotics or antiviral drugs directly attack bacteria or viruses through discerning specific molecules. However, drug abuse could result in antimicrobial resistance and increase infectious disease morbidity. Recently, the exosome therapy, as a HDT, has attracted extensive attentions for its potential in limiting infectious complications and targeted drug delivery. Mesenchymal stem cell-derived exosomes (MSC-Exos) are the most broadly investigated. In this review, we mainly focus on the development and recent advances of the application of MSC-Exos on microbial diseases. The review starts with the difficulties and current strategies in antimicrobial treatments, followed by a comprehensive overview of exosomes in aspect of isolation, identification, contents, and applications. Then, the underlying mechanisms of the MSC-Exo therapy in microbial diseases are discussed in depth, mainly including immunomodulation, repression of excessive inflammation, and promotion of tissue regeneration. In addition, we highlight the latest progress in the clinical translation of the MSC-Exo therapy, by summarizing related clinical trials, routes of administration, and exosome modifications. This review will provide fundamental insights and future perspectives on MSC-Exo therapy in microbial diseases from bench to bedside.

show abstract

“…[34][35][36] There is increasing evidence of biofilm as a predisposing factor linking chronic infection and inflammation to CVD with periodontal disease being the trigger. [37][38][39][40][41] The connection between oral bacteria and cardiac disease has been reported for many years and is not a recent development in the literature. Oral bacteria, specifically Streptococcus mutans (cariogenic) and Porphyromonas gingivalis (periodontitis), can induce platelet aggregation, leading to thrombus formation.…”

Section: Cardiovascular Disease (Cvd)mentioning

confidence: 99%

Oral Biofilms and their Connection to Systemic Health

Kurtzman¹,

Horowitz

Johnson³

et al. 2022

MRAJ

View full text Add to dashboard Cite

Systemic and oral health are interconnected via bacteria and their byproducts which can circulate throughout the body which are found in the oral biofilm. Oral biofilm and its associated periodontal health have not been frequently addressed in patients with systemic health issues. This is especially true for those patients who do not respond to medical treatment via their physician for systemic issues. The periodontal sulcus in the absence of clinical presence of periodontal disease (bleeding on probing, gingival inflammation) may have oral biofilm present. Periodontal reaction is dependent on the patient’s immune response to the associated bacteria and their byproducts present in the oral biofilm. Increasing evidence has emerged in recent years that are connecting oral biofilms with systemic conditions, either by initiating them or by complicating those medical conditions. Patient health needs to be considered as a whole-body system with connections that may originate in the oral cavity and have distant effects throughout the body. In order to maximize the patient’s total health, healthcare needs to be a coordination between the physician and dentist to eliminate the oral biofilm and aid in the prevention of systemic disease or minimize these effects to improve the overall patient health and their quality of life. Various systemic health areas have been associated with the bacteria in oral biofilms and their byproducts. Those include cardiovascular disease, chronic kidney disease, diabetes, pulmonary disease, prostate cancer, colon cancer, pancreatic cancer, pre-term pregnancy, erectile dysfunction, Alzheimer’s disease, and rheumatoid arthritis. This article will discuss oral biofilm, its systemic effects, and review the medical conditions associated with the oral systemic connection with an extensive review of the literature to aid in demonstrating the total body connection.

show abstract

The association between periodontitis and cardiovascular risks in asymptomatic healthy patients

Cited by 14 publications

References 36 publications

The Effect of Periodontal Treatment on the Reactive Hyperemia Index. A 1-Year Follow-Up Pilot Study

The Effect of Periodontal Treatment on the Reactive Hyperemia Index. A 1-Year Follow-Up Pilot Study

Mesenchymal Stem Cell-Derived Exosome Therapy of Microbial Diseases: From Bench to Bed

Oral Biofilms and their Connection to Systemic Health

Contact Info

Product

Resources

About