The association between P selectin glycoprotein ligand 1 gene variable number of tandem repeats polymorphism and risk of thrombosis in Behçet's disease

Coşan, Fulya; Oku, Basar; Totuk, Özgün Melike Gedar; Abacı, Neslihan; Üstek, Duran; Küçükkaya, Reyhan Diz; Gül, Ahmet

doi:10.1111/1756-185x.13151

Cited by 3 publications

(1 citation statement)

References 23 publications

(27 reference statements)

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“…P-selectin (SELP) is mainly expressed on the surface of activated endothelial cells and platelets [11,26]. Its expression upregulation is correlated with the pathogenesis of various diseases, including atherosclerosis [65], thrombosis [66], diabetes [67] and cancer [14,24,25,28,68]. Because P-selectin has been shown to promote the formation of cancer metastases by facilitating the adhesion and migration of tumor cells [24,25], this molecule has emerged as a potential therapeutic strategy for the treatment of various conditions.…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics Analyzes of Selectins Polymorphisms Reveal New Potential Cancer Biomarkers

Rabi¹,

Valente²,

Teixeira³

et al. 2023

Preprint

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Selectins are responsible for the early stages of cell migration as they control cell adhesion. They make the microenvironment permissive for metastatic events by promoting the activation of other cell adhesion molecules (CAMs). We employed several robust bioinformatics tools to evaluate gene sequence; single nucleotide polymorphisms (SNPs) in intronic and UTR regions; and missense SNPs with amino acid change in L-selectin (SELL), E-selectin (SELE), P-selectin (SELP) and PSGL-1 (SELPLG). We demonstrated that gene polymorphisms rs2229569, rs1131498, rs4987360, rs4987301 and rs2205849; polymorphisms rs3917777, rs2205894 and rs2205893 of SELP gene; rs7138370, rs7300972 and rs2228315 variants of SELPLG gene; and rs1534904 and rs5368 polymorphisms of SELE gene may produce important alterations in the DNA structure and consequent alterations in the morphology and function of the corresponding proteins. These Selectin polymorphic variants deserve further investigation in cancer patients, as they may become useful clinical markers for risk determination, diagnostic and prognostic biomarkers or even targets for targeted therapies.

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Section: Discussionmentioning

confidence: 99%

Bioinformatics Analyzes of Selectins Polymorphisms Reveal New Potential Cancer Biomarkers

Rabi¹,

Valente²,

Teixeira³

et al. 2023

Preprint

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show abstract

Potential new cancer biomarkers revealed by quantum chemistry associated with bioinformatics in the study of selectin polymorphisms

Rabi,

Valente,

de Souza Teixeira

et al. 2024

Heliyon

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Correlations of PSGL-1 VNTR polymorphism with the susceptibility to severe HFMD associated with EV-71 and the immune status after infection

Wang,

Qian,

et al. 2024

Virol J

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The association between P selectin glycoprotein ligand 1 gene variable number of tandem repeats polymorphism and risk of thrombosis in Behçet's disease

Abstract: PSGL-1 VNTR polymorphism may have limited contribution to the thrombotic tendency in patients with BD.

Cited by 3 publications

References 23 publications

Bioinformatics Analyzes of Selectins Polymorphisms Reveal New Potential Cancer Biomarkers

Bioinformatics Analyzes of Selectins Polymorphisms Reveal New Potential Cancer Biomarkers

Potential new cancer biomarkers revealed by quantum chemistry associated with bioinformatics in the study of selectin polymorphisms

Correlations of PSGL-1 VNTR polymorphism with the susceptibility to severe HFMD associated with EV-71 and the immune status after infection

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