The association between ophthalmologic diseases and obstructive sleep apnea: a systematic review and meta-analysis

Huon, Leh-Kiong; Liu, Stanley Yung‐Chuan; Camacho, Macario; Guilleminault, Christian

doi:10.1007/s11325-016-1358-4

Cited by 71 publications

(70 citation statements)

References 61 publications

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“…A meta-analysis by Huon et al found a statistically significant association between CSR and OSA after pooling together the results of two case-control studies. 9 A smaller study of 23 consecutive patients with CSR found that 14 of these patients (60.9%) had OSA. 10 Case reports further support the association: a 45-year-old male patient described by Jain et al presented with bilateral CSR that rapidly improved following CPAP treatment.…”

Section: Centr a L Serous R Eti No Path Ymentioning

confidence: 96%

“…The study found an overall OR for OSA of 1.746 among individuals with glaucoma. 9 A number of case reports have suggested the association as well. One such report describes a 60-year-old patient with NTG who displayed progressive visual field worsening despite lowering intraocular pressure with both eye drops and surgical intervention.…”

Section: G L Auco M Amentioning

confidence: 97%

“…9 These occlusion events include branch retinal vein occlusion and central retinal vein occlusion, with occlusion of the branch retinal vein system the more common of the two. In a study of 40 patients having been treated for RVO, 37% of these patients demonstrated sleep-disordered breathing as measured by nocturnal pulse oximetry.…”

Section: Reti Nal V Ei N Occlusi O Nmentioning

confidence: 99%

“…16 Studies have demonstrated an association with OSA and both NTG and OAG. 5,9,17 A meta-analysis of 3 case-control studies, including 711 cases and 6,709 controls, found an odds ratio (OR) of 2.46 for the association between OSA and glaucoma. Among cohort studies, the same meta-analysis found an OR of 1.43.…”

Section: G L Auco M Amentioning

confidence: 99%

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Ocular Manifestations of Obstructive Sleep Apnea

Santos

Hofmann

2017

Journal of Clinical Sleep Medicine

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Study Objectives: Obstructive sleep apnea (OSA) incurs a host of systemic side effects. The eyes are particularly susceptible to both mechanical and vascular sequelae of the disease. This paper outlines the ocular manifestations of sleep apnea. The authors hope to increase awareness of the ocular complications of this common disorder and increase communication and co-management between eye-care providers and sleep specialists alike. Methods: Data were collected from PubMed and the Brown University Library Collection. Results: Twenty-two papers were included in this review to address floppy eyelid syndrome, nonarteritic anterior ischemic optic neuropathy, central serous retinopathy, retinal vein occlusion, and glaucoma. We used three meta-analyses and several cross-sectional cohort and case-control studies that investigate the aforementioned conditions and their associations with OSA. Conclusions: Hypoxia induced by nightly cessation of breathing increases patients' risk of coronary artery disease, heart failure, stroke, and other conditions. As with many maladies detrimental to vascular health, obstructive sleep apnea affects the eye and ocular adnexa. This paper summarizes the current evidence implicating OSA in these ocular maladies and highlights their proposed mechanisms. The authors describe ocular pathology which sleep specialists may encounter. We encourage more aggressive attention to ocular symptoms in patients with sleep apnea to prevent vision-threatening complications. Further research should investigate how sleep apnea treatment affects these ocular findings and identify which sleep apnea patients are most prone to developing ocular pathology. Keywords: eye diseases, obstructive sleep apnea, ophthalmology Citation: Santos M, Hofmann RJ. Ocular manifestations of obstructive sleep apnea.

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Section: Centr a L Serous R Eti No Path Ymentioning

confidence: 96%

Section: G L Auco M Amentioning

confidence: 97%

Section: Reti Nal V Ei N Occlusi O Nmentioning

confidence: 99%

Section: G L Auco M Amentioning

confidence: 99%

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Ocular Manifestations of Obstructive Sleep Apnea

Santos

Hofmann

2017

Journal of Clinical Sleep Medicine

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“…On the other hand, the expiration in SWS can really regulate the vascular circulation in eyes. It has been demonstrated that many vascular diseases of eyes are associated with the obstructive sleep apnea, such as the glaucoma, retinal vein occlusion, nonarteritic anterior ischemic optic neuropathy, central serous chorioretinopathy, floppy eyelid syndrome and so on [47] [48]. In the obstructive sleep apnea, the inspiration can still affect the eye in the same way as in normal subjects, while the expiration is affected somewhat on pressing the posterior palate and maxillary sinuses because of the physical obstacle.…”

Section: The Parallel Neurovascular Regulation In Head Up To Eye Durimentioning

confidence: 99%

One Neglected Yawning Function like Slow Wave Sleep: The Hypothetic Neurovascular Regulation from Mouth to Eye Driven by Expiration

Cai¹

2018

OALib

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In this article, it is considered that the mechanism of yawning function is correlative to sleep. It was revealed from the electrophysiological studies that the slow wave sleep (SWS) was characterized as decrease in excitation from inspiratory motoneurons more than from expiration, manifesting the expiratory activity dominating in SWS. To analogize yawning to SWS, herein it is only considered the expiration during yawning, pressing the sensory posterior palate and maxillary sinuses with air flow, so that yawns similarly regulate the vascular circulations from mouth to eye as SWS, as evidenced by the closure of eyelid in sleep and the association of ophthalmic diseases with obstructive sleep apnea. Besides, it is pointed out that the yawning expiration of high muscular tone elicits the muscular constriction at the back of neck, potentiating the expiratory press in mouth stronger than that of SWS. Accordingly, it is hypothesized that the yawning resembles the SWS to play the neurovascular regulation in head driven by expiration. It is speculated that the initiative mouth opening in yawns may have functions other than that considered here. It is expected that this new and neglected function of yawning with expiratory neurovascular regulation in head may add more to understand the complex functions of yawns.

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Sleep-Related Breathing Disorders and Inflammation: TNF-α and IL-6 as Prototypic Examples

2019

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The association between ophthalmologic diseases and obstructive sleep apnea: a systematic review and meta-analysis

Abstract: Our results suggest significant associations between OSA and glaucoma, NAION, CSR, and FES. Screening for OSA should be considered in patients with glaucoma, NAION, CSR, or FES.

Cited by 71 publications

References 61 publications

Ocular Manifestations of Obstructive Sleep Apnea

Ocular Manifestations of Obstructive Sleep Apnea

One Neglected Yawning Function like Slow Wave Sleep: The Hypothetic Neurovascular Regulation from Mouth to Eye Driven by Expiration

Sleep-Related Breathing Disorders and Inflammation: TNF-α and IL-6 as Prototypic Examples

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