The association between nutritional exposures and metabolic syndrome in the Tehran Lipid and Glucose Study (TLGS): a cohort study

Cheraghi, Zahra; Mirmiran, Parvin; Mansournia, Mohammad Ali; Moslehi, Nazanin; Khalili, Davood

doi:10.1016/j.puhe.2016.07.003

Cited by 13 publications

(26 citation statements)

References 45 publications

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“…The average family income and education levels were not associated with MetS, which might be attributed to the fact that most of the people had lower levels of education (only 6.5% of the people received senior high school education) and average family income (42.8% of the people had a level of income lower than the average income of 6000 RMB/year). Some other known risk factors such as alcohol drinking 22, 23 , salt consuming 24 , and some known protective factors such as fresh fruit and vegetable 25 intake were also observed in this study, but no association with MetS was found. All those results suggested that most people living in rural areas of Southwest China have almost the same lifestyle.…”

Section: Discussionsupporting

confidence: 59%

Prevalence of metabolic syndrome among adults with liver function injury in rural area of Southwest China: A cross-sectional study

Zeng

Lin

Liu

et al. 2017

Sci Rep

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Abnormal liver function (ALF) plays a key role in metabolic syndrome (MetS), but only few data on the relationship between MetS and the risk factors for ALF (e.g., biotoxins) are available. We aimed to provide the prevalence of MetS and its association with the risk factors for ALF in rural area of Southwest China. A cross-sectional study within the hepatocellular carcinoma cohort was conducted, and included 5493 people with age from 30 to 85 years old. MetS was defined according to the Joint Scientific Statement. We observed that the prevalence of MetS was 31.8% (39.0% in women and 19.8% in men). Logistic regression analysis showed that significantly increased risk of MetS was found in those showing ALF (OR = 3.00, 95% CI: 2.43–3.71). Significantly decreased risk of MetS was found in those with higher HBV DNA titers (OR = 0.49, 95% CI: 0.33–0.74), and in those with higher aflatoxin B1 exposure (estimated daily intake, EDI) (OR = 0.60, 95% CI: 0.53–0.67). No significant change was found in those with higher microcystin-LR exposure (EDI). Therefore, the different risk factors for ALF might exert different effects on MetS. However, there should be an interaction effect existing that might decide the severity of MetS.

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Section: Discussionsupporting

confidence: 59%

Prevalence of metabolic syndrome among adults with liver function injury in rural area of Southwest China: A cross-sectional study

Zeng

Lin

Liu

et al. 2017

Sci Rep

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“…For the linear or non-linear dose-response analysis, the natural logarithm of the OR from each study was pooled using random-effect models, which incorporate both within-study and between-study variations (14) . If a study reported the estimates separately according to individual fruits or vegetables (15)(16)(17) or sex (6) , the effect estimates in the same study were combined using a random-effect model in the main analysis.…”

Section: Discussionmentioning

confidence: 99%

“…Full-text of 308 articles was reviewed and the following 299 articles were excluded (online Supplementary Table S2): 119 studies not related to dietary factors, seventy-seven studies not related to outcome, twenty-four reviews or letters, thirty-eight studies for which no full text was available, twenty-two studies that did not report OR/RR or 95 % CI, eight studies not published in English, six studies that did not report data for fruit or vegetable consumption, two clinical studies, one duplicate study and two studies that focused on patients with specific diseases. As a result, a total of nine articles (5)(6)(7)(8)(9)(10)15,17,20) were identified as eligible for the present meta-analysis ( Fig. 1).…”

Section: Literature Search For Dose-response Meta-analysismentioning

confidence: 99%

“…Nine studies (5)(6)(7)(8)(9)(10) including seven cross-sectional studies (5)(6)(7)16,17) and two cohort studies (8,15) were used in the dose-response meta-analysis of the association between fruit or vegetable consumption and chance of the MetS (Table 1). Six studies (5,(8)(9)(10)15,17) were conducted in Asia, and three studies (6,7,16) were conducted in Europe. Seven studies (5)(6)(7)(8)10,15,16) included both male and female participants, and two studies (9,17) included only male or female participants.…”

Section: Study Characteristicsmentioning

confidence: 99%

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Fruit and vegetable consumption and the metabolic syndrome: a systematic review and dose–response meta-analysis

2019

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A systematic review and meta-analysis of observational studies were performed to assess the dose–response associations between fruit or vegetable consumption and the chance of the metabolic syndrome (MetS). Studies on the association between fruit or vegetable consumption and the risk of the MetS published from January 1958 to 30 October 2018 were searched using the PubMed, MEDLINE and Embase databases, and the references of relevant articles were reviewed. Random-effects models were used to estimate the summary OR with 95 % CI for the MetS, and dose–response analysis was conducted to quantify the associations. Heterogeneity among studies was evaluated using Q and I2 statistics. A total of nine observational studies (seven cross-sectional studies and two cohort studies) were included in the meta-analysis. In a dose–response analysis of cohort studies and cross-sectional studies, the summary estimate of the MetS for an increase of 100 g/d in fruit consumption (nine studies) was 0·97 (95 % CI 0·95, 0·99; I2 = 26·7 %), whereas an increase of 100 g/d in vegetable consumption (nine studies) was not associated with a reduction in the MetS (OR 0·98; 95 % CI 0·96, 1·01; I2 = 54·6 %). In conclusion, an increased intake of fruit may reduce the risk of the MetS. For future research, prospective studies or randomised clinical trials are needed to identify the effects of fruits and vegetables by variety on the risk of the MetS.

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“…Fruit and vegetable consumption has been recognized as an important dietary factor that could reduce the development of many chronic diseases [1,2], including metabolic syndrome [3,4,5], obesity [6], diabetes [7] and cardiovascular incidents, such as hypertension [8,9], coronary heart disease, stroke [10] and myocardial infarction [8], which are currently the leading causes of death in the world [11,12]. …”

Section: Introductionmentioning

confidence: 99%

Strawberry (cv. Romina) Methanolic Extract and Anthocyanin-Enriched Fraction Improve Lipid Profile and Antioxidant Status in HepG2 Cells

Forbes‐Hernández

Gasparrini

Afrin

et al. 2017

IJMS

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Dyslipidemia and oxidation of low density lipoproteins (LDL) are recognized as critical factors in the development of atherosclerosis. Healthy dietary patterns, with abundant fruit and vegetable consumption, may prevent the onset of these risk factors due to the presence of phytochemical compounds. Strawberries are known for their high content of polyphenols; among them, flavonoids are the major constituents, and it is presumed that they are responsible for the biological activity of the fruit. Nevertheless, there are only a few studies that actually evaluate the effects of different fractions isolated from strawberries. In order to assess the effects of two different strawberry extracts (whole methanolic extract/anthocyanin-enriched fraction) on the lipid profile and antioxidant status in human hepatocellular carcinoma (HepG2) cells, the triglycerides and LDL-cholesterol content, lipid peroxidation, intracellular reactive oxygen species (ROS) content and antioxidant enzymes’ activity on cell lysates were determined. Results demonstrated that both strawberry extracts not only improved the lipid metabolism by decreasing triglycerides and LDL-cholesterol contents, but also improved the redox state of HepG2 cells by modulating thiobarbituric acid-reactive substances production, antioxidant enzyme activity and ROS generation. The observed effects were more pronounced for the anthocyanin-enriched fraction.

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The association between nutritional exposures and metabolic syndrome in the Tehran Lipid and Glucose Study (TLGS): a cohort study

Cited by 13 publications

References 45 publications

Prevalence of metabolic syndrome among adults with liver function injury in rural area of Southwest China: A cross-sectional study

Prevalence of metabolic syndrome among adults with liver function injury in rural area of Southwest China: A cross-sectional study

Fruit and vegetable consumption and the metabolic syndrome: a systematic review and dose–response meta-analysis

Strawberry (cv. Romina) Methanolic Extract and Anthocyanin-Enriched Fraction Improve Lipid Profile and Antioxidant Status in HepG2 Cells

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