The association between nonalcoholic fatty liver disease and risk of colorectal adenoma and cancer incident and recurrence: a meta-analysis of observational studies

Chen, Jin; Bian, Dongxue; Zang, Shufei; Yang, Zongxing; Tian, Guoyan; Luo, Yan; Yang, Jing; Xu, Beibei; Shi, Junping

doi:10.1080/17474124.2019.1580143

Cited by 32 publications

(27 citation statements)

References 44 publications

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“…In a previous meta-analysis which investigated the association of incident and recurrent colorectal cancer and adenoma with NAFLD, it was observed that the presence and severity of NAFLD were associated with an increased risk of incident colorectal cancer or adenomas [53]. When Mantovani et al examined the association between NAFLD and colorectal tumors in asymptomatic adults who underwent a screening colonoscopy, they found that NAFLD was associated with a moderate increase in the risk of colorectal cancer and adenoma [54].…”

Section: Discussionmentioning

confidence: 99%

Association between nonalcoholic fatty liver disease and extrahepatic cancers: a systematic review and meta-analysis

Liu

Zhao

et al. 2020

Lipids Health Dis

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Background: NAFLD is tightly associated with various diseases such as diabetes, cardiovascular disease, kidney disease, and cancer. Previous studies had investigated the association between NAFLD and various extrahepatic cancers, but the available data to date is not conclusive. The aim of this study was to investigate the association between NAFLD and various extrahepatic cancers comprehensively. Methods: Searches were conducted of various electronic databases (PubMed, EMBASE, Medline, and the Cochrane Library) to identify observational studies published between 1996 and January 2020 which investigated the association between NAFLD and extrahepatic cancers. The pooled OR/HR/IRR of the association between NAFLD and various extrahepatic cancers were analyzed. Results: A total of 26 studies were included to investigate the association between NAFLD and various extrahepatic cancers. As the results shown, the pooled OR values of the risk of colorectal cancer and adenomas in patients with NAFLD were 1.72 (95%CI: 1.40-2.11) and 1.37 (95%CI: 1.29-1.46), respectively. The pooled OR values of the risk of intrahepatic cholangiocarcinoma and extrahepatic cholangiocarcinoma in patients with NAFLD were 2.46 (95%CI: 1.77-3.44) and 2.24 (95%CI: 1.58-3.17), respectively. The pooled OR value of the risk of breast cancer in patients with NAFLD was 1.69 (95%CI: 1.44-1.99). In addition, NAFLD was also tightly associatied with the risk of gastric cancer, pancreatic cancer, prostate cancer, and esophageal cancer. Conclusions: NAFLD could significantly increase the development risk of colorectal adenomas and cancer, intrahepatic and extrahepatic cholangiocarcinoma, breast, gastric, pancreatic, prostate, and esophageal cancer. NAFLD could be considered as one of the influencing factors during the clinical diagnosis and treatment for the extrahepatic cancers.

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Section: Discussionmentioning

confidence: 99%

Association between nonalcoholic fatty liver disease and extrahepatic cancers: a systematic review and meta-analysis

Liu

Zhao

et al. 2020

Lipids Health Dis

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“…In recent years, there has been a growing interest in the understanding of the relationships between the hepatic manifestation of the metabolic syndrome, represented by nonalcoholic fatty liver disease (NAFLD), and the development of colorectal polyps [83,84]. NAFLD is a significant risk factor for adenomatous and hyperplastic polyps in males as compared with females [85,86], although Li et al had demonstrated that NAFLD is a greater factor for the adenomatous polyp development in women than in men [87].…”

Section: Modifiable Factorsmentioning

confidence: 99%

Molecular Aspects of Colorectal Adenomas: The Interplay among Microenvironment, Oxidative Stress, and Predisposition

Aceto

Catalano

Curia

2020

BioMed Research International

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The development of colorectal cancer (CRC) is a multistep process initiated by a benign polyp that has the potential to evolve into in situ carcinoma through the interactions between environmental and genetic factors. CRC incidence rates are constantly increased for young adult patients presenting an advanced tumor stage. The majority of CRCs arise from colonic adenomas originating from aberrant cell proliferation of colon epithelium. Endoscopic polypectomy represents a tool for early detection and removal of polyps, although the occurrence of cancers after negative colonoscopy shows a significant incidence. It has long been recognized that the aberrant regulation of Wingless/It (Wnt)/β-Catenin signaling in the pathogenesis of colorectal cancer is supported by its critical role in the differentiation of stem cells in intestinal crypts and in the maintenance of intestinal homeostasis. For this review, we will focus on the development of adenomatous polyps through the interplay between renewal signaling in the colon epithelium and reactive oxygen species (ROS) production. The current knowledge of molecular pathology allows us to deepen the relationships between oxidative stress and other risk factors as lifestyle, microbiota, and predisposition. We underline that the chronic inflammation and ROS production in the colon epithelium can impair the Wnt/β-catenin and/or base excision repair (BER) pathways and predispose to polyp development. In fact, the coexistence of oxidative DNA damage and errors in DNA polymerase can foster C>T transitions in various types of cancer and adenomas, leading to a hypermutated phenotype of tumor cells. Moreover, the function of Adenomatous Polyposis Coli (APC) protein in regulating DNA repair is very important as therapeutic implication making DNA damaging chemotherapeutic agents more effective in CRC cells that tend to accumulate mutations. Additional studies will determine whether approaches based on Wnt inhibition would provide long-term therapeutic value in CRC, but it is clear that APC disruption plays a central role in driving and maintaining tumorigenesis.

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“…NAFLD-Patienten haben zudem ein erhöhtes Risiko, ein extrahepatisches Karzinom (v.a. kolorektales Karzinom) zu entwickeln oder an einer chronischen Nierenerkrankung zu leiden [17,18]. Ergänzend dazu konnte eine Metaanalyse von Dulai und Kollegen nachweisen, dass auch die allgemeine Sterblichkeit signifikant mit dem Fibrosestadium bei einer NASH ansteigt [19].…”

Section: Klinik Und Relevanzunclassified

Die nicht-alkoholische Fettlebererkrankung bei Kindern und Jugendlichen – ein Update

Kalveram

Wiegand

2020

Adipositas - Ursachen, Folgeerkrankungen, Therapie

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ZusammenfassungDie nicht-alkoholische Fettlebererkrankung (NAFLD) ist die häufigste chronische Lebererkrankung im Kindes- und Jugendalter und eng mit Übergewicht und Adipositas assoziiert. Es kommt zur Fetteinlagerung in die Hepatozyten – teilweise mit Inflammation, welche den fibrotischen und zirrhotischen Umbau des Lebergewebes zur Folge haben kann. Die Ursachen sind nicht vollständig geklärt; als Risikofaktoren gelten hyperkalorische Ernährung, Übergewicht, Insulinresistenz und genetische Determinanten. Betroffene zeigen meist keine Symptome und fallen erst durch erhöhte Leberwerte auf. Dann sollte eine Kontrolle und gegebenenfalls eine erweiterte differenzialdiagnostische Abklärung erfolgen. Zur Diagnosesicherung bedarf es einer Leberbiopsie. Als vielversprechende nicht-invasive Alternativen werden bisher bildgebende Verfahren, klinische Scores und Serummarker weiter validiert. Die Therapie der NAFLD besteht aus einer Lifestyle-Modifikation mit regelmäßiger Bewegung und einer ausgewogenen, fruktosearmen Ernährung. Gelingt es Patienten, Gewicht zu verlieren, ist die Prognose gut, und fibrotische Veränderungen sind potenziell reversibel. Kommt es hingegen zu einer weiteren Gewichtszunahme schreitet die Erkrankung fort und kann in einem Leberversagen enden. Eine frühzeitige Diagnose und Therapieeinleitung sind daher essenziell.

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The association between nonalcoholic fatty liver disease and risk of colorectal adenoma and cancer incident and recurrence: a meta-analysis of observational studies

Cited by 32 publications

References 44 publications

Association between nonalcoholic fatty liver disease and extrahepatic cancers: a systematic review and meta-analysis

Association between nonalcoholic fatty liver disease and extrahepatic cancers: a systematic review and meta-analysis

Molecular Aspects of Colorectal Adenomas: The Interplay among Microenvironment, Oxidative Stress, and Predisposition

Die nicht-alkoholische Fettlebererkrankung bei Kindern und Jugendlichen – ein Update

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