The Association Between Mitochondrial tRNAGlu Variants and Hearing Loss: A Case-Control Study
Xuejiao Yu,
Sheng Li,
Qinxian Guo
et al.
Abstract:Purpose
This study aimed to examine the frequencies of mt-tRNA
Glu
variants in 180 pediatric patients with non-syndromic hearing loss (NSHL) and 100 controls.
Methods
Sanger sequencing was performed to screen for mt-tRNA
Glu
variants. These mitochondrial DNA (mtDNA) pathogenic mutations were further assessed using phylogenetic conservation and haplogroup analyses. We also traced the origins of the family history of p… Show more
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