The association between migraines and periodontal disease: A systematic review of clinical studies

Dholakia, Sonu B.; Rao, P. Mallikarjuna; Talluri, Sandeep; Khan, Junad

doi:10.1016/j.job.2023.04.001

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…With the available studies and limited evidences, it is seen that none of the criteria are being fully satisfied to prove the causality and hence further long-term studies and case control studies with a stringent study protocol and absence of confounding variables are required to further assess the nature of association between both the diseases. Recently, Dholakia et al [ 51 ] and Mohammed et al [ 22 ] in systematic reviews tried to assess the association of migraine and periodontitis by studying the role of various inflammatory markers such as CGRP, IL-6 and TNF- α elevation. Various cross-sectional studies have been conducted and have delivered results pointing out to just mere association of both the diseases and not proving the causation.…”

Section: Nature Of Association—bradford Hill Criteriamentioning

confidence: 99%

Exploring the Potential Consortium of Migraine and Periodontitis

Ponnaiyan,

Rughwani,

Shetty

et al. 2024

International Journal of Dentistry

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Objectives. Various researches have shown periodontitis to share common pathophysiological pathways with systemic diseases such as diabetes, cardiovascular diseases, and osteoporosis and recently neurological disorders. This article provides a narrative review summarizing the various linking mechanisms and the nature of association between two multifactorial diseases—periodontitis and migraine. Materials and Methods. A literature search was performed for articles related to periodontitis and migraine up till the year 2023 which yielded totally 14 articles. There were only three randomized controlled clinical trials; therefore, we were unable to conduct a systematic review and focused on a narrative review. The keywords searched were “migraine”, “periodontitis” and “biomarkers” in PubMed/Medline, Web of Science, and Embase databases. Any article related to the association of periodontitis and migraine and the dental management of subjects with headache disorders were included and studies with migraine and other dental diseases were excluded. Results. It is found that the occurrence of periodontitis and migraine are associated with each other. There is reasonable evidence to believe that periodontitis and migraine are linked by direct and indirect mechanisms which can eventually lead to chronic inflammatory conditions like periodontitis worsening neurovascular conditions such as migraine. However, upon detailed analysis it was found that the strength of association is weak owing to the presences of various common confounding and risk factors. Conclusions. The association between periodontitis and migraine cannot be denied, however, not all the criteria are fulfilled while examining the nature of association and future long-term studies are required to prove the same. Clinical Relevance. Various studies have reported poor periodontal health in patients with migraine. The risk of exacerbation of migraine also increases in subject undergoing dental therapy if the triggering factors are manipulated. Hence, knowing the precise pathophysiologic mechanisms linking both the diseases would be favorable in planning treatment protocols for subjects with migraine.

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Section: Nature Of Association—bradford Hill Criteriamentioning

confidence: 99%

Exploring the Potential Consortium of Migraine and Periodontitis

Ponnaiyan,

Rughwani,

Shetty

et al. 2024

International Journal of Dentistry

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“…Early identification and treatment of these risk factors are crucial for high-risk patients susceptible to early-onset headaches. Additionally, several chronic inflammatory conditions such as systemic lupus erythematosus ( 4 ), inflammatory bowel disease ( 5 ), and chronic periodontitis ( 6 ) are recognized as significant risk factors for headaches.…”

Section: Introductionmentioning

confidence: 99%

Association of atopic dermatitis and headache disorder: a systematic review and meta-analyses

Yang,

Dai,

et al. 2024

Front. Neurol.

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BackgroundGrowing evidence suggests that headache disorders and atopic dermatitis share similar pathological mechanisms and risk factors. The aim of this study was to assess the risk for headache disorders in patients with atopic dermatitis.MethodsWe systematically searched the PubMed and Embase databases from inception to December 1, 2023, for observational studies that examined risk of migraine in subjects with atopic dermatitis. Risk estimates from individual studies were pooled using random-effects models.ResultsTen studies with 12,717,747 subjects were included in the meta-analysis. Our results showed that patients with atopic dermatitis were associated with a higher risk of headache disorder (OR, 1.46, 95% CI = 1.36–1.56; P < 0.001; I2 = 98%) or migraine (OR, 1.32, 95% CI = 1.18–1.47; P < 0.001; I2 = 98.9%). Most of the results of the subgroup analyses were consistent with the overall results.ConclusionThe findings of this meta-analysis suggest that atopic dermatitis is a potential risk indicator for headache disorder or migraine. Further studies are still needed to verify our findings due to the substantial heterogeneity in our analyses.

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Oral biosciences: The annual review 2023

Ohshima,

Mishima

2024

Journal of Oral Biosciences

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The association between migraines and periodontal disease: A systematic review of clinical studies

Cited by 3 publications

References 28 publications

Exploring the Potential Consortium of Migraine and Periodontitis

Exploring the Potential Consortium of Migraine and Periodontitis

Association of atopic dermatitis and headache disorder: a systematic review and meta-analyses

Oral biosciences: The annual review 2023

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