The Association Between Lung Cancer and Sarcoidosis: A Literature Review

Abstract

Lung cancer is responsible for a significant number of cancer-related deaths worldwide. While various factors can lead to lung cancer, such as tobacco smoking, this article focuses on the relationship between sarcoidosis, a multisystem granulomatous disorder, and lung neoplasm. To investigate this association, the authors conducted a literature search using relevant keywords. The analysis of these reports concluded that while Sarcoidosis and lung cancer together is rare, it is possible. The presenting symptoms, age, gender, and diagnostic procedures of each case should be evaluated, and appropriate diagnostic procedures should be carried out to determine the appropriate treatment for each patient. Clinicians need to be aware of the possibility of these two diseases co-occurring, as they can impact the management of the patient's condition, whether it is curative or palliative. It is essential to rule out metastatic cancer in individuals with sarcoidosis-like clinical and radiographic features.

Recurrence of sarcoidosis accompanied by lung cancer after drug‐induced pulmonary sarcoidosis with lung injury

“…The frequency of concurrent sarcoidosis and lung cancer is very low at <1%. 1 Sakula et al has reported three possible relationships between sarcoidosis and lung cancer: 3 reaction to lung cancer. (III) Sarcoidosis precedes the development of lung cancer, and the occurrence of lung cancer is entirely coincidental.…”

“…Mediastinal lymphadenopathy looks like lung cancer metastasis on chest CT and PET‐CT. The frequency of concurrent sarcoidosis and lung cancer is very low at <1% 1 . Sakula et al has reported three possible relationships between sarcoidosis and lung cancer: 3 (I) Sarcoidosis precedes the development of lung cancer, connects and predisposes to the malignant change.…”

“…T helper (Th) 1-mediated immune reaction is essential for granuloma formation in sarcoidosis, frequently localized in the lungs, hilar/mediastinal lymph nodes and eyes. 1 We herein report a case of pulmonary sarcoidosis presented after shin'iseihaito administration. 2 This is a followup of the same case demonstrating sarcoidosis recurrence with the development of lung cancer.…”

“…Sarcoidosis is a multisystem granulomatous disease of unknown cause. T helper (Th) 1‐mediated immune reaction is essential for granuloma formation in sarcoidosis, frequently localized in the lungs, hilar/mediastinal lymph nodes and eyes 1 …”