The association between lesion location, sex and poststroke depression: Meta‐analysis

Abstract

BackgroundPoststroke depression (PSD) is a common form of stroke patients. Whether the risk of PSD is influenced by the stroke lesion location and sex remains a matter of debate. The objective of this study was to examine the association between the risk of PSD and the stroke lesion location and sex by performing a systematic meta‐analysis.MethodsSubgroup analyses were performed according to the time interval after stroke onset to assessment for PSD. A total of 31 reports involving 5,309 subjects (for lesion location analysis) and 5,489 subjects (for sex analysis) suffering from stroke were included in this meta‐analysis.ResultsThe pooled odds ratio (OR) of PSD after a left‐hemisphere stroke, compared with a right‐hemisphere stroke was 1.11 (95% confidence interval [CI] 0.82–1.49) and OR of PSD after a male stroke, compared with a female stroke was 0.68 (95% CI 0.58–0.81). Subacute poststroke subgroup (1–6 months) significantly favored PSD occurring after a left hemisphere stroke (OR = 1.50, 95% CI 1.21–1.87). Furthermore, there was a statistically significant association between PSD and female stroke for studies with acute poststroke group (OR = 0.73, 95% CI 0.62–0.86) and subacute poststroke stroke phase (OR = 0.69, 95% CI 0.56–0.86).ConclusionsThis systematic review suggests that patients with left hemisphere stroke may be more susceptible to PSD during subacute phase of stroke and female stroke may be more susceptible to PSD during acute and subacute phase of stroke.

The association between mean platelet volume levels and poststroke depression

“…We found that female gender was significantly correlated with PSD, which was consistent with earlier findings (Guiraud et al, 2016; Mazure, Weinberger, Pittman, Sibon, & Swendsen, 2014; Zhang, Zhao, Fang, Wang, & Zhou, 2017). Our results also showed that physical disability and stroke severity were correlated with PSD, which were in line with previous researches (Eriksen, Gay, & Lerdal, 2016; Ko et al, 2018; Kutlubaev & Hackett, 2014; Sarfo et al, 2017).…”

The association of different types of cerebral infarction with post-stroke depression and cognitive impairment

“…First, in this study, we did not consider the impact of the sex difference on the results because of the limited samples. As previous studies showed that sex may influence the incidence of PSD in stroke patients [ 23 ] , sex should be considered in the future study. Second, in the study, we employed MMSE as the measurement of general cognitive functions rather than montreal cognitive assessment, Alzheimer's disease assessment scale-cognitive subscale, or Addenbrooke's cognitive examination-revised-R, etc.…”

Xingnao Jieyu Decoction Ameliorates Poststroke Depression through the BDNF/ERK/CREB Pathway in Rats

“…Depression following stroke is more common than in other physical illnesses with similar levels of physical disability; a direct biological link exists between stroke and depression [ 28 , 29 ]. Neuronal loss and apoptosis are induced by ischemic or hemorrhagic stroke and can contribute to disorders of cognition, language, behavior, and emotion [ 30 , 31 ]. Promoting neuronal survival, repair, and regeneration is valuable to prevent and treat stroke complications, such as PSD; this strategy has been considered a window for understanding antidepression management.…”