The association between large congenital melanocytic naevi and cutaneous melanoma: preliminary findings from an Internet-based registry of 379 patients

Abstract

There is ample evidence in the literature to support the fact that there is an increased risk of the development of melanoma in individuals with a large congenital melanocytic naevus (LCMN). The published melanoma risk estimates, by and large, do not distinguish between cutaneous and extracutaneous melanomas. It is currently not known to what extent each contributes to the overall cited melanoma risk estimates. In order to obtain a better understanding of the association between LCMN and cutaneous melanoma arising within an LCMN, we report the preliminary findings of a cross-sectional study of 379 patients, with a median age of 3 years, from the first self-referred, Internet-based registry of patients with LCMN. To date, no cutaneous melanoma has been reported; possible reasons for this finding are discussed. Further research is required to clarify the risk of the development of cutaneous melanoma separate from non-cutaneous melanoma and to identify subgroups of patients with LCMN at highest risk for the development of melanoma. This information will help to formulate appropriate decisions concerning the management of patients with LCMN.

Large or multiple congenital melanocytic nevi: Occurrence of neurocutaneous melanocytosis in 1008 persons

“…8,9,25 The occurrence of symptomatic NCM among those with truncal LCMN was 4.8% in our group. These figures certainly are far higher than those in the general population.…”

Large or multiple congenital melanocytic nevi: Occurrence of cutaneous melanoma in 1008 persons

“…Nonetheless, our results were generally compatible with other major studies published. 5,8,11,13,14,26 CONCLUSIONS On the basis of data from a large cohort of 1008 affected persons, LCMN of the garment type were associated with a low cutaneous melanoma occurrence of 2.9%. Although females with a garment nevus were more prevalent, males were at higher risk for development of cutaneous melanoma.…”

“…The largest previously published cohort numbered 379 persons, also similarly entered via another Internet-based nevus support group. 13,14 Large congenital melanocytic nevi (LCMN) are generally defined as a nevus that has or is predicted to have a largest diameter of at least 20 cm at adulthood. Infants with a nevus at least 9 cm in diameter on the skull or 6 cm in diameter on the body and persons with a nevus covering a substantial portion of a small area of the body (eg, face, hand, or foot) were included.…”

Neues über kongenitale melanozytäre Nävi

“…In mehreren, z. T. prospektiven Studien fand sich eine symptomatische NCM bei ca. 5-7% der Patienten mit CMN > 20 cm [20,22,23]. Kinsler Die v. a. in Deutschland verbreitete Früh-dermabrasion und das in Belgien entwickelte Verfahren der neonatalen Küretta-ge können als früh-ablative CMN-Therapien zusammengefasst werden.…”