The association between Ki-67 expression and the clinical pathological characteristics of colorectal cancer

Abstract

Background: This study will explore the association between Ki-67 expression and clinical pathological characteristics (CPC) of colorectal cancer (CC). Methods: We will search relevant studies from electronic databases (Cochrane Library, PUBMED, EMBASE, Scopus, Cumulative Index to Nursing and Allied Health Literature, China Biology Medicine, and China National Knowledge Infrastructure) from beginning to April 1, 2020 without language and publication time limitations. We will consider all case-controlled studies (CCSs) or randomized controlled studies (RCSs) investigating the association between Ki-67 expression and CPC of CC. We will appraise study quality of CCSs by Newcastle–Ottawa Scale, and RCSs by Cochrane risk of bias tool. Statistical analysis will be carried out by Review Manager 5.3 software. Results: The present study will explore the association between Ki-67 expression and CPC of CC. Conclusion: Its findings may summarize scientific evidence of the association between Ki-67 expression and CPC of CC, and may provide helpful evidence for clinical practice. Systematic review registration: PROSPERO CRD42020173795.

Antitumor activity of 5-fluorouracil polymeric nanogel synthesized by gamma radiation on a rat model of colon carcinoma: a proposed mechanism

“…Owing to its role in cellular proliferation in all phases of the cell cycle except G0, it is strongly correlated to the overexpressed AKT due to regulating the tumor cell cycle from G1 to the S phase thus aggravating the proliferation levels of cancerous cells [ 48 ]. Li et al [ 49 ] indicated that abnormal activation of AKT and Ki-67 promoted colon cancer development and progression in addition to invasion and metastasis Considering the aforementioned data our results revealed a strong positive expression of Ki-67 in the tissues of rats with colon cancer which agree with the results of Xiao et al [ 50 ] who conducted a noticeable upregulated expression of Ki-67 in mice with colorectal cancer induced by AOM-DSS.…”

Prognostic and Clinicopathological Value of Ki-67 in Melanoma: A Meta-Analysis

“…Immunohistochemical (IHC) staining is usually used to detect Ki-67, and the expression level of Ki-67 is related to cell proliferation activity, disease progression and cancer recurrence ( 7 ). Some studies have shown that Ki-67 is one of the prognostic indices of multiple solid tumors, such as nasopharyngeal carcinoma ( 8 ), stage I non-small cell lung cancer ( 9 ), gastrointestinal stromal tumour ( 10 ), and gliomas ( 11 ), resected triple-negative breast cancer ( 12 ), colorectal cancer ( 13 ), hepatocellular carcinoma ( 14 ), and thyroid cancer ( 15 ). Previous studies have shown an association between Ki-67 expression and melanoma patient prognosis, but the results have been contradictory ( 16 – 25 ).…”

Quantitative parameters of dual-layer spectral detector computed tomography for evaluating Ki-67 and human epidermal growth factor receptor 2 expression in colorectal adenocarcinoma

“…Our result also showed that CT 40keV in VP, Zeff in VP, IC in VP, and λ HU in VP were positively correlated with the expression of CRAC Ki-67. It has been speculated that this correlation can be attributed to the high expression of Ki-67 being related to the increase in tumor blood supply, which leads to a higher CT value on 40-keV VMI ( 1 , 17 ). Compared with other VMIs, 40-keV VMI exhibits the best signal-to-noise ratio and contrast-to-noise ratio ( 18 , 19 ), which can significantly improve the detection of lesions, as 40-keV is infinitely close to the 33-keV level of the iodine k edge ( 20 , 21 ).…”

“…Colorectal cancer (CRC) is the third most common cancer in men and the second most common cancer in women, while having the highest cancer mortality in the world ( 1 ). The majority of CRC cases are colorectal adenocarcinoma (CRAC) ( 2 ).…”