The association between iodine intake and semen quality among fertile men in China

Sun, Yu; Chen, Chen; Liu, Gordon G.; Wang, Meijiao; Shi, Cuige; Guo, Yu; Lv, Fang; Wang, Ning; Zhang, Shucheng

doi:10.1186/s12889-020-08547-2

Cited by 6 publications

(5 citation statements)

References 30 publications

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“…Iodine is also an essential micronutrient for the thyroid gland to synthesize thyroid hormones ( 39 ). Previous studies have identified that both iodine deficiency and iodine excess may lead to thyroid dysfunction ( 40 , 41 ). Thus, we carried out subgroup analyses stratified by urine iodine concentration.…”

Section: Discussionmentioning

confidence: 99%

Relationship between dietary selenium intake and serum thyroid function measures in U.S. adults: Data from NHANES 2007–2012

et al. 2022

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Although numerous studies have explored the relationship between selenium intake and thyroid diseases, few epidemiological studies have investigated the association between selenium intake and thyroid hormones. Therefore, we conducted this analysis to investigate the association between dietary selenium intake and thyroid hormones. Our sample included 5,575 adults (age ≥ 20) years from the National Health and Nutrition Examination Survey (NHANES) 2007–2012. Thyroid hormones, including total triiodothyronine (T3), total thyroxine (T4), free T3 (FT3), free T4 (FT4), and thyroid-stimulating hormone (TSH), were detected. Multivariable linear regression models showed that log10-transformed selenium intake (LogSe) was negatively correlated with TT4 (β = −0.383, 95% CI: −0.695, −0.070) and TT4/TT3 (β = −0.003, 95% CI: −0.006, −0.0004) in U.S. adults. Besides, additional stratified analyses by sex demonstrated that LogSe was negatively associated with TT4 (β = −0.007, 95% CI: −0.013, −0.001) and TT4/TT3 (β = −0.664, 95% CI: −1.182, −0.146) and positively associated with FT4/TT4 (β = 0.031, 95% CI: 0.004, 0.059) in male adults. Meanwhile, subgroup analysis by iodine status showed that LogSe was negatively associated with TT4 (β = −0.006, 95% CI: −0.011, −0.002), FT4/FT3 (β = −0.011, 95% CI: −0.023, −0.00002) and TT4/TT3 (β = −0.456, 95% CI: −0.886, −0.026) in iodine sufficiency but not in iodine deficiency adults. Our results demonstrated that the increased dietary selenium intake was negatively correlated with TT4 and TT4/TT3 in U.S. adults. Furthermore, the association between dietary selenium intake and thyroid hormones was more pronounced in males and iodine sufficiency adults.

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Section: Discussionmentioning

confidence: 99%

Relationship between dietary selenium intake and serum thyroid function measures in U.S. adults: Data from NHANES 2007–2012

et al. 2022

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“…Our results lend, in part, credence to those of Lotti et al [ 31 ], who found that the euthyroid subjects ( n = 145) had lower semen volumes compared to those with subclinical hyperthyroidism ( n = 6) and higher than those with subclinical hypothyroidism ( n = 12); however, no association of the semen parameters with TSH was noted. In a large ( n = 1098) study from China, suboptimal or excessive dietary iodine intake was associated with a slightly lower semen volume compared to the optimal dietary iodine intake; however, the authors did not present the thyroid function status [ 32 ]. The most prominent effect of thyroid function abnormalities on semen parameters seems to be on impaired motility [ 33 , 34 , 35 ] and/or morphology [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Study on the Interaction between Serum Thyrotropin and Semen Parameters in Men

et al. 2022

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The effect of thyroid function on semen parameters has been studied in pathological conditions in small studies. With this research work, we aimed to study thyroid hormone effects on semen parameters in 130 men who were evaluated for couple subfertility. Our study was cross-sectional. We noted semen volume, sperm concentration, total sperm count, testosterone levels and thyrotropin (TSH) levels. The analysis included ordinary least squares regression (OLS-R), quantile regression (QR) and segmented line regression (SR). Using OLS-R, a weak negative correlation was found between the logTSH levels and semen volume (r = −0.16, r2 = 0.03, p = 0.05). In Q-R, each incremental unit increase in logTSH decreased the mean semen volume between −0.78 ± 0.44 and −1.33 ± 0.34 mL (40–60th response quantile) and between −1.19 ± 0.71 and −0.61 ± 0.31 mL (70–90th response quantile) (p = 0.049). With SR, a biphasic relationship of sperm concentration with TSH was noted (positive turning to negative, peaking at TSH = 1.22 μIU/mL). Thus, a weak negative association between the TSH levels and semen volume was noted, showing a trough within the usual normal range for TSH. Moreover, a biphasic relationship between the sperm concentration and TSH was also noted, peaking at approximately mid-normal TSH levels. Based on our results, TSH explained slightly less than 3% of the variation in semen volume and 7% of the sperm concentration (thus, other factors, which were not studied here, have a more important effect on it).

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“…Hypothyroidism, whether subclinical or overt, has been linked to an increased risk of coronary artery disease. This is thought to be due to the effects of low thyroid hormone levels on lipid metabolism and vascular function [27]. Insulin resistance is a condition related to glucose regulation, in which the response of the liver, muscle, adipose tissue, and other body tissues to insulin is less than what is expected [28].…”

Section: Table 4 Statistics Output Of Roc Analysis Of Markers Between...mentioning

confidence: 99%

Assessing the role of serum Pentraxin-3 (PTX3) levels in hypothyroidism patients as risk marker of insulin resistance

Jafar,

Ali,

Ali

et al. 2023

Current Issues in Pharmacy and Medical Sciences

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Introduction. Hypothyroidism is a common endocrine disorder that affects millions of people worldwide. The diagnosis and monitoring of this condition often rely on thyroid hormone levels, which can be limited in their accuracy. Pentraxin 3 (PTX3) is a protein family that is involved in the innate immune response and is distinguished by its distinct pentameric structure. Aim. To evaluate the utility of serum PTX3 levels in detecting and monitoring hypothyroidism. Materials and Methods. A case-control design of the study included 90 participants between the ages of 20 and 50 years. These participants were divided into three groups: overt hypothyroidism (OH), subclinical hypothyroidism (SCH), and a control group of healthy individuals. Anthropometric data, including age, sex, weight, height, body mass index (BMI), and hormonal parameters were measured and recorded for each participant. Results. Our work demonstrates that serum PTX3 levels were significantly elevated in individuals with hypothyroidism, compared to those with normal thyroid function (p<0.001). Furthermore, PTX3 levels correlated positively with TSH levels (r=0.62, p<0.001) and negatively with T4 levels (r= -0.53, p<0.001). Conclusion. The findings suggest that serum PTX3 levels can be a useful biomarker for detecting and monitoring hypothyroidism, particularly in cases of SCH. The study’s exclusion criteria made sure that no other systemic illnesses or medication use could have tainted the findings. Therefore, the use of plasma PTX3 levels in hypothyroidism detection and monitoring may prove to be a valuable clinical tool in the future.

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The association between iodine intake and semen quality among fertile men in China

Cited by 6 publications

References 30 publications

Relationship between dietary selenium intake and serum thyroid function measures in U.S. adults: Data from NHANES 2007–2012

Relationship between dietary selenium intake and serum thyroid function measures in U.S. adults: Data from NHANES 2007–2012

Study on the Interaction between Serum Thyrotropin and Semen Parameters in Men

Assessing the role of serum Pentraxin-3 (PTX3) levels in hypothyroidism patients as risk marker of insulin resistance

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