The association between intron 4 VNTR, E298A and IVF 23+10 G/T polymorphisms of ecNOS gene and sildenafil responsiveness in patients with erectile dysfunction

Peşkircioğlu, Levent; Ataç, Fatma Belgin; Erdem, Remzi; Deveci, Serkan; Verdı, Hasıbe; Özkardeş, Hakan

doi:10.1038/sj.ijir.3901501

Cited by 31 publications

(25 citation statements)

References 23 publications

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“…We also analyzed the relationship between VNTR polymorphism and ED, but we found no difference in the genotypic and allelic frequencies between patients and controls. Our results also coincided with the results of Peskircioglu et al., who reported no association between the ecNOS intron 4 VNTR polymorphism and ED [13].…”

Section: Discussionsupporting

confidence: 93%

eNOS Gene Intron 4 VNTR and Exon 7-G894T Polymorphisms in Turkish Men with Erectile Dysfunction: A Case Control Study

Erol

Bozdogan

Akduman

et al. 2009

The Journal of Sexual Medicine

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Introduction The associations between the gene polymorphisms and erectile dysfunction (ED) are limited. Aim To examine a potential association between variable number of tandem repeats (intron 4 VNTR), G894T polymorphisms, and ED in Turkish men. Methods Sixty-four men with ED and 82 healthy men as a control group were included in the study. The patients were evaluated by medical history, International Index of Erectile Function (IIEF), serum glucose, and lipid profiles. VNTR and G894T polymorphism were assessed by isolated DNA blood samples obtained from the patient group with ED and controls. Main Outcome Measures Assesment of IIEF and VNTR and G894T polymorphism in the isolated DNA blood samples. Results Genotype distributions of endothelial nitric oxide syntase (eNOS) gene intron 4 VNTR polymorphisms in the patient group were similar to those in the healthy group (P > 0.05). The frequency of the eNOS gene intron 4 genotype was found as bb: 55 (67.1%), ab: 26 (31.7%), and aa: 1 (1.2%) in the controls and bb: 43 (67.2%), ab: 19 (29.7%), and aa: 2 (3.1%) in the patient group. The frequency of the G894T was found as gg: 61 (74.4%), gt: 21 (25.6%), and tt: 0 (0.0%) in the controls and gg: 32 (50.0%), gt: 27 (42.1%), and tt: 5 (7.8%) in the patient group (P = 0.002). The frequencies of the “t” allele were 21 (12.8%) in the control group and 37 (28.9%) in the patient group (P = 0.001). Logistic regression analysis showed that G894T polymorphism was an independent risk factor for ED. Conclusions We found significant differences in allelic and genotypic frequencies between patients and controls for the G894T eNOS polymorphisms. The presence of 894T allele in carriers increased the risk of ED. No association was found between VNTR polymorphism and in patients with ED.

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Section: Discussionsupporting

confidence: 93%

eNOS Gene Intron 4 VNTR and Exon 7-G894T Polymorphisms in Turkish Men with Erectile Dysfunction: A Case Control Study

Erol

Bozdogan

Akduman

et al. 2009

The Journal of Sexual Medicine

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“…Besides, 2 low-quality studies were also excluded ( Figure 1 ). Finally, 12 studies were enrolled into our meta-analysis 22526373839404142434445. The subjects in these 12 studies were Asians (5 studies) and Caucasians (7 studies), and the studies contained a combined total of 1962 ED patients and 1752 healthy controls.…”

Section: Resultsmentioning

confidence: 99%

Association of endothelial nitric oxide synthase polymorphisms with an increased risk of erectile dysfunction

et al. 2017

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The purpose of our meta-analysis is to examine the associations between three single nucleotide polymorphisms of endothelial nitric oxide synthase (eNOS) gene, G894T, intron 4 and T-786C, and the risk of erectile dysfunction. An electronic database search was performed to identify case-control studies reporting the association between single nucleotide polymorphisms of eNOS gene and erectile dysfunction. Stringent inclusion and exclusion criteria were employed to select high-quality studies for this meta-analysis. Comprehensive Meta-analysis 2.0 software (Biostat Inc., Englewood, New Jersey, USA) was used for statistical analysis of the data extracted from the selected studies. From the initial 203 articles retrieved from database search, this meta-analysis finally selected 12 high-quality case-control studies that conformed to our inclusion criteria. The 12 studies contained a total of 1962 patients with erectile dysfunction and 1752 healthy controls. The results of our meta-analysis showed that G894T correlated with an increased risk erectile dysfunction under both the allele and dominant models (allele: OR = 1.556, 95% CI = 1.064–2.275, P = 0.023; dominant: OR = 1.613, 95% CI = 1.050–2.476, P = 0.029). A similar association was found between T-786C and erectile dysfunction under the allele model (OR = 1.679, 95% CI = 1.341–2.102, P < 0.001), but not under the dominant model (all P > 0.05). Our meta-analysis showed that the two single nucleotide polymorphisms in eNOS gene, G894T and T-786C, are strongly associated with the risk of erectile dysfunction.

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“…Peskircioglu et al. recently evaluated the influence of eNOS gene polymorphisms and sildenafil responsiveness [79]. In contrast to the case‐control genetic association studies, the “a” allele carriers of the intron 4 VNTR responded to sildenafil significantly better than the “bb” homozygous individuals.…”

Section: Resultsmentioning

confidence: 99%

Genetics of Erectile Dysfunction: A Review of the Interface between Sex and Molecular Biomarkers

Andersen

Guindalini

Tufik

2011

The Journal of Sexual Medicine

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Introduction In recent years, new tools for the study of molecular biology and genetics have resulted in significant contributions to the scientific community. The potential use of genetic variations as biomarkers in the management of current and future conditions is generating considerable excitement in health care for disorders such as erectile dysfunction (ED). Aim This review briefly describes the molecular and genetic mechanisms involved in ED and provides an overall view of the literature relevant to possible relationships between genetic factors and ED. Methods This is a narrative review of studies on the potential influence of polymorphisms on the risk of developing ED. Main Outcome Measure We reviewed genetic association studies involving polymorphisms and the ED phenotype. Results There is growing evidence for the influence of genetic polymorphisms on the risk of ED and on the interindividual variability in sildenafil treatment. Conclusions Although this field is still in its infancy, genetic association studies aimed at defining a molecular basis for ED have provided some important evidence that a patient's genotype may be used in the future to assess risk, as well as to plan treatment and prevention programs in the clinic.

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The association between intron 4 VNTR, E298A and IVF 23+10 G/T polymorphisms of ecNOS gene and sildenafil responsiveness in patients with erectile dysfunction

Cited by 31 publications

References 23 publications

eNOS Gene Intron 4 VNTR and Exon 7-G894T Polymorphisms in Turkish Men with Erectile Dysfunction: A Case Control Study

eNOS Gene Intron 4 VNTR and Exon 7-G894T Polymorphisms in Turkish Men with Erectile Dysfunction: A Case Control Study

Association of endothelial nitric oxide synthase polymorphisms with an increased risk of erectile dysfunction

Genetics of Erectile Dysfunction: A Review of the Interface between Sex and Molecular Biomarkers

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