The association between interleukin polymorphism and recurrent aphthous stomatitis: A meta-analysis

Wu, Donglei; Xin, Jinglei; Liu, Jing; Zhou, Peng

doi:10.1016/j.archoralbio.2018.05.011

Cited by 12 publications

(20 citation statements)

References 25 publications

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“…Children with RAS along with symmetric enamel defects should be evaluated for celiac disease [39,45]. A history of skin, genital, or ocular ulcerative lesions with arthritis should prompt an evaluation for conditions such as Behçet's disease, MAGIC, and Reiter's syndromes [47][48][49]. Multiple conditions involve RAS along with recurring fever and infection including PFAPA syndrome, cyclic neutropenia, and Sweet's syndrome [50][51][52].…”

Section: Recurrent Aphthous Stomatitis and Associated Conditionsmentioning

confidence: 99%

Ulcerated Lesions of the Oral Mucosa: Clinical and Histologic Review

Fitzpatrick

Cohen

Clark

2019

Head and Neck Pathol

134

103

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Ulcerated lesions of the oral cavity have many underlying etiologic factors, most commonly infection, immune related, traumatic, or neoplastic. A detailed patient history is critical in assessing ulcerative oral lesions and should include a complete medical and medication history; whether an inciting or triggering trauma, condition, or medication can be identified; the length of time the lesion has been present; the frequency of episodes in recurrent cases; the presence or absence of pain; and the growth of the lesion over time. For multiple or recurrent lesions the presence or history of ulcers on the skin, genital areas, or eyes should be evaluated along with any accompanying systemic symptoms such as fever, arthritis, or other signs of underlying systemic disease. Biopsy may be indicated in many ulcerative lesions of the oral cavity although some are more suitable for clinical diagnosis. Neoplastic ulcerated lesions are notorious in the oral cavity for their ability to mimic benign ulcerative lesions, highlighting the essential nature of biopsy to establish a diagnosis in cases that are not clinically identifiable or do not respond as expected to treatment. Adjunctive tests may be required for final diagnosis of some ulcerated lesions especially autoimmune lesions. Laboratory tests or evaluation to rule out systemic disease may be also required for recurrent or severe ulcerations especially when accompanied by other symptoms. This discussion will describe the clinical and histopathologic characteristics of a variety of ulcerated lesions found in the oral cavity. KeywordsOral ulcer • Herpetic gingivostomatitis • Aphthous stomatitis • Oral erythema multiforme • Oral medication related ulcer • Oral lichen planus • Oral vesiculobullous lesions • Traumatic oral ulcer • Oral squamous cell carcinoma • Oral lymphoma

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Section: Recurrent Aphthous Stomatitis and Associated Conditionsmentioning

confidence: 99%

Ulcerated Lesions of the Oral Mucosa: Clinical and Histologic Review

Fitzpatrick

Cohen

Clark

2019

Head and Neck Pathol

134

103

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“…Mostly commonly seen in the buccal mucosa, labial mucosa and tongue which are self limited to 7-14 days with frequent reoccurrences [2]. Patients with RAS often have a lot of pain, and the symptoms can have a big influence on their quality of life [3]. Since it is a self limiting condition, there is no definitive curative treatment to prevent the recurrence and also the etiopathogenesis of RAS is not known.…”

Section: Introductionmentioning

confidence: 99%

“…However, multiple investigations have revealed that immunologic, genetic, allergy, dietary, and microbiological variables all have a role. The role of genetic predisposition in the occurrence of RAS has recently been examined, as persons with a positive family history had a higher incidence of the condition [3]. Multifunctional cytokines that mediate the immune response and may be responsible for the formation of RAS ulcers are engaged in the inflammatory response.…”

Section: Introductionmentioning

confidence: 99%

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The Association of Interleukin 1 Beta in Recurrent Aphthous Stomatitis – A Systematic Review

Viswasini

Ramani

Gheena

2021

JPRI

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Background: Recurrent aphthous stomatitis (RAS) is a chronic ulcerative disease with a complex aetiology and a strong immunological basis. The prototypical pro-inflammatory cytokine is interleukin-1 (IL-1). IL-1alpha and IL-1beta are the two subtypes of IL-1. The proinflammatory cytokine interleukin-1beta is a key mediator of inflammation which affects cell proliferation and differentiation. Aim: To systematically review the association of Interleukin 1 beta with the recurrent aphthous stomatitis. Methods: A comprehensive search was done using electronic data bases such as PubMed Central, Google Scholar and direct web search. The title scan was used to find relevant articles, which were then read and appraised for inclusion. This review analysed all research that investigated the use of IL1 beta with RAS. Results: Electronic database search identified 31 articles. After evaluating the title, abstract, and full text of these articles, only 2 were selected for the present systematic review. A final of 2 studies were included based on the inclusion criteria to meet the research question. Conclusion: This current study shows that IL1 beta is not a significant reliable indication of RAS. The association of IL1 beta and RAS varies due to a variety of confounding variables.

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“…[4–6] The most characteristic symptom of this disease is the single or multiple painful ulcers that appear around the oral mucosa, even on the tongue and lips. [7,8] According to clinical features, RAS are mainly divided into 3 types, minor RAS, which is the most common type, major RAS whose diameter is greater than 10 cm, and herpetiform RAS. [9–11] The pain causes obstacles to eating and drinking, affecting the daily life of patients.…”

Section: Introductionmentioning

confidence: 99%

Chinese herbal medicine for recurrent aphthous stomatitis: a protocol for systematic review and meta-analysis

Zhang

Kuo

et al. 2018

Medicine

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Background:Recurrent aphthous stomatitis (RAS) is the most frequent form of oral ulceration, characterized by recurrent oral mucosal ulceration in an otherwise healthy individual. This study was designed to evaluate the efficacy and safety of Chinese herbal medicine for recurrent aphthous stomatitis.Methods:Five databases will be searched from inception to date, including PubMed, Cochrane Library, EMBASE,CNKI, and CBM. The researchers will comprehensively screen clinical randomized trials of Chinese herbal medicine for recurrent aphthous stomatitis. The review will be conducted by 2 independent authors without time and language limitation. The risk of bias will be assessed by the Cochrane risk of bias tool.Results:Ethical approval is not required because this study is based on published papers. After peer-review, the study will be disseminated in scientific journals and conferences.Conclusion:This systematic review will provide evidence for the efficacy and safety of Chinese medicine for recurrent aphthous stomatitis.PROSPERO registration:CRD42018111955.

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The association between interleukin polymorphism and recurrent aphthous stomatitis: A meta-analysis

Cited by 12 publications

References 25 publications

Ulcerated Lesions of the Oral Mucosa: Clinical and Histologic Review

Ulcerated Lesions of the Oral Mucosa: Clinical and Histologic Review

The Association of Interleukin 1 Beta in Recurrent Aphthous Stomatitis – A Systematic Review

Chinese herbal medicine for recurrent aphthous stomatitis: a protocol for systematic review and meta-analysis

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