The Association Between Inflammation and Angiogenesis in Human Pancreatic Adenocarcinoma

Tănase, Cristiana; Necula, Laura; Neagu, Ana Iulia; Albulescu, Radu

doi:10.21614/jtmr-21-2-78

Cited by 1 publication

(2 citation statements)

References 45 publications

(40 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is why there is a need to focus on improving risk stratification and identifying early stage disease or premalignant lesions, while they are still resectable [ 7 ] Patients with tumors bigger than 5 cm, localized in the body or/and tail; patients with tumors bigger than 5-6 cm, even localized in the head; p21—negative; p53—positive; Ki 67 in 30-35% of tumoral cells; with endoluminal necrosis, intravascular tumoral emboli, and presence of metastases—had a poor prognosis and increased risk for metastases (when these are absent at the time of diagnosis) and recurrences Presence of perineural invasion and number of affected regional lymph nodes could not be correlated with prognostic factors or survival [ 17 ] CD 68 was positive in peritumoral tissue, in about 55-60% of well-differentiated G1 cases. The interaction between pancreatic cancer cells and tumor-associated macrophages remains to be established and may play a pivotal role in the progression of pancreatic cancer [ 18 , 19 ] …”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

A Morphological and Immunohistochemical Study of the Tumoral and Inflammatory Cells in Pancreatic Ductal Adenocarcinoma

Herlea

Mustafa

Iorgescu

et al. 2020

Journal of Immunology Research

View full text Add to dashboard Cite

This study is aimed at investigating tumoral and inflammatory cells and the significance of the prognostic factors of pancreatic ductal adenocarcinoma (PDAC); it is also aimed at determining the role of immunohistochemistry in the diagnosis and prognosis of this neoplasm. Materials and Methods. 230 cases of pancreatic ductal adenocarcinoma were included in the study group; these cases were selected from the archives of the Department of Pathology of the Fundeni Clinical Institute over a ten-year period. Immunohistochemistry was performed using the following antibodies: MUC 1, CD 34, Factor VIII, CD 68, MMP-7, CEA, p21, p53, and Ki 67. Results. There were 133 male (57.8%) and 97 female (42.2%) patients included in this study, with ages between 20 and 81 years old (mean age: 58.2 years) and with tumors located in the pancreatic head ( n = 196 ; 85.2%), pancreatic body ( n = 12 ; 5.2%), and pancreatic tail ( n = 20 , 8.7%), as well as panpancreatic tumors ( n = 2 ; 0.9%). Patients presented with early stages (IA and IB), with low pathologic grade (G1), with small size tumors (less than 1-1.5 cm), with tumors located in the head of the pancreas, (p53: negative; p21: positive; and CD 68: positive in peritumoral tissue), with low nuclear index ( Ki 67 < 10 % ), without metastases at the time of surgery (had a better prognosis), and with a survival rate of about 7 months. Conclusions. Immunohistochemistry is useful for an accurate diagnosis, differential diagnosis, and establishment of additional factors that might have a prognostic importance. It is recommended to study peritumoral tissue from the quantitative and qualitative points of view to increase the number of prognostic factors. This study represents a multidisciplinary approach, and it is a result of teamwork; it presents histopathological methods of examination of this severe illness and describes only a part of the scientific effort to determine the main pathological mechanisms of this neoplasm.

show abstract

Section: Resultsmentioning

confidence: 99%

“…CD 68 was positive in peritumoral tissue, in about 55-60% of well-differentiated G1 cases. The interaction between pancreatic cancer cells and tumor-associated macrophages remains to be established and may play a pivotal role in the progression of pancreatic cancer [ 18 , 19 ]…”

Section: Resultsmentioning

confidence: 99%