The Association between Idiopathic Pulmonary Fibrosis and Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis

Karuga, Filip Franciszek; Kaczmarski, Piotr; Szmyd, Bartosz; Białasiewicz, Piotr; Sochal, Marcin; Gabryelska, Agata

doi:10.3390/jcm11175008

Cited by 9 publications

(6 citation statements)

References 91 publications

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“…Some findings of prospective studies, including ours, on the prevalence of OSA in IPF and ILD populations are presented in Table 4 [ 15 , 16 , 18 , 22 – 28 , 30 , 32 – 37 ]. This search was not systematic, but includes all the studies (with sample size > ten subjects) reported in a recent systematic review on the topic [ 47 ]. Differences between these studies may be due to variations in age, sex, BMI, treatment, disease severity of populations, and methods.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Obstructive Sleep Apnea in a Population of Subjects with Interstitial Lung Diseases

et al. 2023

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Introduction Obstructive sleep apnea (OSA) is often observed in subjects with interstitial lung disease (ILD). It may have a negative impact on the course of ILD, but its prognostic significance in relation to other known indicators of poor outcome is unclear. Methods After a detailed work-up, including overnight unattended type III polygraphy, all subjects newly diagnosed with ILDs referred to our clinics were followed-up for at least 1.5 years or until death or progression of disease [> 10% decline in forced vital capacity (FVC) below baseline]. We analyzed relationships between some prespecified variables of interest, including sleeping results, to establish parameters predictive of progressive course. Results Our population consisted of 46 subjects (mean age 59.6 years; males 61%); 23.9% and 41% had idiopathic pulmonary fibrosis and ILD associated with systemic diseases, respectively. Mean baseline forced vital capacity and diffusion capacity of carbon monoxide were 83% and 57% of predicted, respectively. Mean (± SE) Apnea–Hypopnea Index (AHI) was 17 (± 3) events/h. AHI in the ranges 5–14.9, 15–29.9, and ≥ 30 was recorded in 14 (31%), 6 (13%), and 9 (20%) subjects, respectively. Mean distance covered in the 6-MWG walk test (6MWT) was 302 (± 19) m and 26 subjects (57%) showed exertional oxyhemoglobin desaturation. The median follow-up was about 18 months. Multivariate logistic regression analysis showed that exertional desaturation (HR 8.2; 1.8–36.5 95% CI; p = 0.006) and AHI ≥ 30, namely the threshold of severe OSA (HR 7.5; 1.8–30.6; p = 0.005), were the only independent variables related to progressive disease course. Conclusion We conclude that exertional desaturation and elevated AHI had independent negative prognostic significance in our ILD population.

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Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Obstructive Sleep Apnea in a Population of Subjects with Interstitial Lung Diseases

et al. 2023

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“…Obstructive sleep apnea has an increased prevalence in idiopathic PF [ 207 , 208 ] and leads to additional difficulties such as cognitive impairment [ 209 ]. Sleep apnea may promote fibrotic mechanisms [ 210 ].…”

Section: Sleep Apnea and Pulmonary Fibrosismentioning

confidence: 99%

Role of Sensory Nerves in Pulmonary Fibrosis

Norton

2024

IJMS

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Pulmonary fibrosis results from the deposition and proliferation of extracellular matrix components in the lungs. Despite being an airway disorder, pulmonary fibrosis also has notable effects on the pulmonary vasculature, with the development and severity of pulmonary hypertension tied closely to patient mortality. Furthermore, the anatomical proximity of blood vessels, the alveolar epithelium, lymphatic tissue, and airway spaces highlights the need to identify shared pathogenic mechanisms and pleiotropic signaling across various cell types. Sensory nerves and their transmitters have a variety of effects on the various cell types within the lungs; however, their effects on many cell types and functions during pulmonary fibrosis have not yet been investigated. This review highlights the importance of gaining a new understanding of sensory nerve function in the context of pulmonary fibrosis as a potential tool to limit airway and vascular dysfunction.

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“…Many factors affect its expression, including age, sex, ethnicity, bodily characteristics, comorbidities and sleep posture, as well as sleep stage, all of which collectively contribute to defining the endotypic and phenotypic features of OSA. and the features of respiratory events according to sleep stages [10]. The scope of this review is to examine the evidence underpinning the assertion that REM OSA may constitute a different phenotype in the heterogeneous constellation of OSA.…”

Section: Introductionmentioning

confidence: 99%

REM sleep obstructive sleep apnoea

Bonsignore,

Mazzuca,

Baiamonte

et al. 2024

Eur Respir Rev

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Obstructive sleep apnoea (OSA) can occur in both rapid eye movement (REM) and non-REM sleep or be limited to REM sleep, when the upper airway is most prone to collapse due to REM sleep atonia. Respiratory events are usually longer and more desaturating in REM than in NREM sleep. The prevalence of REM OSA is higher in women than in men and REM OSA usually occurs in the context of mild–moderate OSA based on the apnoea–hypopnoea index calculated for the entire sleep study. Studies have highlighted some detrimental consequences of REM OSA; for example, its frequent association with systemic hypertension and a degree of excessive daytime sleepiness similar to that found in nonsleep-stage-dependent OSA. Moreover, REM OSA could increase cardiometabolic risk. Continuous positive airway pressure (CPAP) treatment aimed at preventing REM OSA should be longer than the 4 h usually considered as good compliance, since REM sleep occurs mostly during the second half of the night. Unfortunately, patients with REM OSA show poor adherence to CPAP. Alternative non-CPAP treatments might be a good choice for REM OSA, but data are lacking. This review summarises the available data on REM OSA and critically examines the weaknesses and strengths of existing literature.

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The Association between Idiopathic Pulmonary Fibrosis and Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis

Cited by 9 publications

References 91 publications

Prognostic Significance of Obstructive Sleep Apnea in a Population of Subjects with Interstitial Lung Diseases

Prognostic Significance of Obstructive Sleep Apnea in a Population of Subjects with Interstitial Lung Diseases

Role of Sensory Nerves in Pulmonary Fibrosis

REM sleep obstructive sleep apnoea

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