The Association betweenHelicobacter pyloriInfection and Body Weight among Children

Abstract

PurposeWe performed to reveal the association between the Helicobacter pylori infection and body weight among children.MethodsOut retrospective study included patients who underwent the H. pylori immunoglobulin G testing at Konyang University Hospital between March 2011 and June 2014. These patients were classified as seropositive (28 boys, 27 girls; mean age: 9.89±3.28 years) or seronegative (55 boys, 54 girls; mean age: 9.84±3.02 years). Next, we compared various characteristics between the seropositive and negative groups, as well as between obese children (body weight ≥90th percentile) and non-obese children (body weight <90th percentile). Furthermore, we compared the change in body weight after 2 months of treatment with amoxicillin, clarithromycin and omeprazole among the 55 seropositive children (14 treated children and 41 non-treated children).ResultsThere were no differences in the weights and laboratory data for the 55 seropositive children and 109 seronegative children (weight; 40.96±18.11 kg vs. 36.85±13.72 kg, respectively; p=0.14). And, there was no difference in the prevalence of H. pylori infection among the 29 obese and 135 non-obese children (p=0.581). However, after 2 months of eradication, the 14 treated patients exhibited a significant weight gain (+0.91±0.52 kg), compared to the 41 non-treated patients (-0.29±1.16 kg, p=0.025).ConclusionOur findings present that obesity was not associated with the H. pylori infection, although H. pylori eradication led to significant increase in body weight.

Helicobacter pylori Seropositivity in Children in Duhok City, Iraq

“…While H. pylori was associated in several studies, no relationship was found between H. pylori and increased BMI (Ioannou et al, 2005;Marcela et al, 2007;Arslan et al, 2009). On the other hands, several studies showed an increase in BMI after H. pylori eradication (Ioannou et al, 2005;Choi et al, 2016). In our study, no relationship was found between BML levels and H. pylori positivity.…”

“…The role of breastfeeding is controversial. Results of some studies found breastfeeding as a risk factor due to intimate contact between the infant and its infected mother (Malaty et al, 1996;Dore et al, 2002;Fialho et al, 2010;Choi et al, 2016). No study has been conducted in Duhok city determining H. pylori infection associated risk factors.…”

Gut microbiome can be restored without adverse events after Helicobacter pylori eradication therapy in teenagers

“…30 A retrospective study reported that children administered H. pylori eradication therapy exhibited a significant weight gain compared to untreated children. 31 Thus, future studies are required to investigate whether early H. pylori eradication is necessary to prevent H. pylori-associated diseases including GC and their transmission to descendants. 32 The European and North American Societies for Pediatric Gastroenterology, Hepatology, and Nutrition recommend the use of triple therapy including proton-pump inhibitors (PPIs) in combination with amoxicillin and either imidazole or clarithromycin as a first-line treatment method for H. pylori eradication therapy in children.…”

Possible association of ghrelin/obestatin balance with cardiometabolic risk in obese subjects with Helicobacter pylori

“…H. pylori is a common infection having a role in the development of different gastric lesions (Carabotti et al 2014). Several studies have stated that infection of H. pylori is associated with various extragastric conditions, such as diabetes mellitus (DM), dyslipidemia, and cardiovascular disease (Quatrini et al 2001;Choi et al 2016).…”