The Association Between Hyperlipidemia and In-Hospital Outcomes in Takotsubo Cardiomyopathy

Li, Pengyang; Lu, Xiaojia; Teng, Catherine; Hadley, Michelle; Cai, Ping; Dai, Qiying; Wang, Bin

doi:10.2147/dmso.s282009

Cited by 15 publications

(8 citation statements)

References 48 publications

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“…However, the rates of cardiac arrest, ventricular arrhythmia, and acute kidney injury did not differ significantly between the two groups (1162 patients with HLD and 1162 patients without HLD), the author attributed this result to statin use, the protection of low‐density lipoprotein cholesterol binding lipopolysaccharide in sepsis, and underlying malnutrition in patients without HLD. 128 More research is needed to study the association between TCM and HLD.…”

Section: Factors Affecting Prognosis Of Takotsubo Cardiomyopathymentioning

confidence: 99%

Prognostic factors of Takotsubo cardiomyopathy: a systematic review

Teng

et al. 2021

ESC Heart Failure

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Takotsubo cardiomyopathy (TCM), characterized by reversible ventricular dysfunction, has similar mortality to acute coronary syndrome. With the growing interest in the diagnosis of and interventions for TCM, many risk factors had been found to affect the prognosis of TCM patients, such as age, sex, and pre-existing diseases. Because of the incomplete understanding of the pathophysiologic mechanism in TCM, evidence-based medical therapy for this condition is lacking. Early intervention on risk factors may improve the outcomes of TCM. In this review, we sought to provide up-to-date evidence on risk factors and medical therapies that affect TCM outcome. We found that male sex, physical triggers, and certain comorbidities such as chronic kidney disease, malignant disease, higher body mass index, sepsis, chronic obstructive pulmonary disease, and anaemia were associated with poor TCM prognosis. In contrast, race, hyperlipidaemia, diabetes mellitus, and mood disorders were not clearly associated with TCM prognosis. We also reviewed the effect of medical therapies on TCM outcome, including angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, β-blockers, calcium channel blockers, and statins. The evidence that these medications confer a survival benefit on TCM patients is limited. Understanding these prognostic factors could help develop risk-stratification tools for TCM and establish effective prevention and interventions for this notso-benign condition. Further multicentre clinical studies with large samples and meta-analyses of findings from previous studies are needed to address the inconsistent findings among the many potential risk factors for TCM.

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Section: Factors Affecting Prognosis Of Takotsubo Cardiomyopathymentioning

confidence: 99%

Prognostic factors of Takotsubo cardiomyopathy: a systematic review

Teng

et al. 2021

ESC Heart Failure

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“…The impact of HLD on the prognosis of TCM patients is yet to be determined. In a retrospective cohort study, HLD‐TCM group had lower rates of in‐hospital mortality (1.1% vs. 2.4%, p = .027), acute respiratory failure (9.1% vs. 12.1%, p = .022) and cardiogenic shock (3.4% vs. 5.6%, p = .012), shorter length of stay (3.20 ± 3.27 vs. 3.57 ± 3.14 days, p = .005), and lower total charges (p = .013) compared to non‐HLD‐TCM group 31 . However, another study using the same database, found HLD was not associated with the in‐hospital mortality in TCM patients though the mortality rate in each group was not reported (p = .147) 32 .…”

Section: Resultsmentioning

confidence: 99%

Conventional cardiovascular risk factors associated with Takotsubo cardiomyopathy: A comprehensive review

Liang

Zhang

et al. 2021

Clinical Cardiology

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Takotsubo cardiomyopathy (TCM), characterized by transient left ventricular dysfunction, was first reported in Japan in 1990. Current research suggests that TCM can be affected by conventional cardiovascular factors such as hypertension (HTN), diabetes, hyperlipidemia (HLD), and obesity. Despite the increasing interest in this disease, research on TCM remains limited. Conventional cardiovascular factors are clinically related to the outcome of TCM. We reviewed the publications published in PubMed database between January 01 2010 and January 15 2021, and summarized the most current available evidence on the correlation between TCM and the conventional cardiovascular factors. TCM patients are predominantly postmenopausal women. Men and young patients are less commonly seen, but are prone to acute adverse complications and poor prognosis. HTN is common in patients with recurrent TCM. Existing evidence suggests that obesity and chronic kidney disease are related to poor prognosis in TCM. HLD is reported to be associated with fewer complications, though current evidence is limited. Finally, the relationship between diabetes and TCM prognosis is ambivalent. Current evidence suggests conventional cardiovascular risk factors are associated with the outcome of TCM, especially with mortality and complications. More prospective studies are needed to clarify the relationship between each risk factor and the prognosis of TCM.

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“…Patients who had no discharge status were excluded. Patient and hospital demographics (age; sex; race; geographic location; household income; primary payer; and hospital type, region, and size by number of beds); common cardiovascular comorbidities (eg, smoking, hypertension); and other reported risk factors for TTS (including hyperlipidemia, 14 chronic obstructive pulmonary disease, 15 , 16 anxiety, 17 depression, 18 obesity, 19 diabetes, 20 and chronic kidney disease 21 ) were selected as covariates.…”

Section: Methodsmentioning

confidence: 99%

Incidence and Impact of Takotsubo Syndrome in Hospitalized Patients With COVID-19

Li,

Shi,

et al. 2024

Texas Heart Institute Journal

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Background: Takotsubo syndrome has been reported in patients with COVID-19, although minimal data are available. This investigation assessed the incidence and impact of takotsubo syndrome on patients hospitalized with COVID-19. Methods: A retrospective cohort study was conducted using International Statistical Classification of Diseases, Tenth Revision, codes to identify patients with a primary diagnosis of COVID-19 with or without takotsubo syndrome in the National Inpatient Sample 2020 database. Outcomes between groups were compared after propensity score matching for patient and hospital demographics and comorbidities. Results: A total of 211,448 patients with a primary diagnosis of COVID-19 were identified. Of these, 171 (0.08%) had a secondary diagnosis of takotsubo syndrome. Before matching, patients with COVID-19 and takotsubo syndrome, compared with patients without takotsubo syndrome, were older (68.95 vs 64.26 years; P < .001); more likely to be female (64.3% vs 47.2%; P < .001); and more likely to have anxiety (24.6% vs 12.8%; P < .001), depression (17.5% vs 11.4%; P = .02), and chronic obstructive pulmonary disease (24.6% vs 14.7%; P < .001). The takotsubo syndrome group had worse outcomes than the non–takotsubo syndrome group for death (30.4% vs 11.1%), cardiac arrest (7.6% vs 2.1%), cardiogenic shock (12.9% vs 0.4%), length of hospital stay (10.7 vs 7.5 days), and total charges ($152,685 vs $78,468) (all P < .001). After matching and compared with the non–takotsubo syndrome group (n = 508), the takotsubo syndrome group (n = 170) had a higher incidence of inpatient mortality (30% vs 14%; P < .001), cardiac arrest (7.6% vs 2.8%; P = .009), and cardiogenic shock (12.4% vs 0.4%; P < .001); a longer hospital stay (10.7 vs 7.6 days; P < .001); and higher total charges ($152,943 vs $79,523; P < .001). Conclusion: Takotsubo syndrome is a rare but severe in-hospital complication in patients with COVID-19.

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The Association Between Hyperlipidemia and In-Hospital Outcomes in Takotsubo Cardiomyopathy

Cited by 15 publications

References 48 publications

Prognostic factors of Takotsubo cardiomyopathy: a systematic review

Prognostic factors of Takotsubo cardiomyopathy: a systematic review

Conventional cardiovascular risk factors associated with Takotsubo cardiomyopathy: A comprehensive review

Incidence and Impact of Takotsubo Syndrome in Hospitalized Patients With COVID-19

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