The association between HLA and non-Hodgkin lymphoma subtypes, among a transplant-indicated population

Abstract

Several studies have implicated HLA in non-Hodgkin lymphoma (NHL) subtype etiology. However, NHL patients indicated for stem cell transplants are underrepresented in these reports. We therefore evaluated the association between HLA and NHL subtypes among a transplantindicated population. One thousand three hundred and sixty-six NHL patients HLA-typed and indicated for transplant at the City of Hope National Medical Center (Duarte, CA) were compared to 10,271 prospective donors. Odds ratios and 95% confidence intervals were calculated for HLA haplotype and alleles, adjusted for sex and age. The HLA-A Ã

Exploration of a Novel Prognostic Risk Signatures and Immune Checkpoint Molecules in Endometrial Carcinoma Microenvironment

“…Among these candidate genes in OS-and DFS-risk model, HLA-A was reported to be associated with non-Hodgkin lymphoma [33] . KIAA1755 was found as an effective biomarker for early diagnosis, prognosis, and treatment response in ovarian cancer [34] .…”

Human Leucocyte Antigen A Alleles in The Prediction of Post-Kidney Transplant Lymphoproliferative Disorders, A Single-Center Study

“…HLA class I is heterodimer of polymorphic-polypeptide chain and B2-microglobulin, which deliver peptides from an endogenous source to cytotoxic T-cells and expressed in somatic cells. HLA class II is heterodimer of alfa and beta polypeptide chains, that deliver extracellular peptides and presented them to helper T-cells (1,2) .…”

“…T-cells recognize HLA molecules as pathogen and tumour peptides, which activate adaptive immune responses. With most polymorphic human genes, HLA haplotypes are greatly implicated in the causes and outcomes of immune conditions and hematopoietic malignancy (1,2) . Since a correlation between HLA and Hodgkin's lymphoma "HL" was first described in 1967, a lot of studies found links between HL risk with single nucleotide polymorphisms (SNPs) and HLA allele variants.…”

Genetic associations with lymphomas in Polish patients: A pooled‐DNA genome‐wide association analysis

“…Of the latter, DLBCL (ICD‐10; C83) represented approximately 47% of new cases of NHL. According to genome‐wide association study (GWAS) data obtained from over 3000 and 4000 patients of European ancestry with HL and NHL, respectively, both human leukocyte antigen (HLA) region associations and non‐HLA associations for HL and NHL risk have been established (Cerhan et al., 2014; Cozen et al., 2014; Enciso‐Mora et al., 2010; Frampton et al., 2013; Urayama et al., 2012; Zhong et al., 2019). There is potential to discover additional risk variants by GWAS; however, the statistical power of published studies has been limited (Thomsen et al., 2015).…”

“…region associations and non-HLA associations for HL and NHL risk have been established (Cerhan et al, 2014;Cozen et al, 2014;Enciso-Mora et al, 2010;Frampton et al, 2013;Urayama et al, 2012;Zhong et al, 2019). There is potential to discover additional risk variants by GWAS; however, the statistical power of published studies has been limited (Thomsen et al, 2015).…”