The Association between Hemoglobin A1c and the Severity of Coronary Artery Disease in Non-diabetic Patients with Acute Coronary Syndrome

Abstract

Open Access Original Article

Hemoglobin A1c and Angiographic Severity with Coronary Artery Disease: A Cross-Sectional Study

“…With increasing HbA1c levels, a marked increase in SYNTAX score was noted in the patients without a history of taking Statins Epidemiologic studies show that HbA1c is a cardiovascular risk factor in all kinds of individuals. [3][4][5][6][7][8][9][10] Our findings are in accordance with prior studies that demonstrated that HbA1c levels are independently associated with SYNTAX score which represents the degree of coronary atherosclerosis in non-diabetic and diabetic individuals. This association is graded, continuous, and independent of conventional major cardiovascular risk factors and history of taking cardiovascular related drugs.…”

“…There are lots of researches elaborating the effects of glycemic metabolism on CAD. 2–10 These studies show that HbA1C were correlated positively with the Severity of CAD in different groups of people, such as older patients with diabetes mellitus, 8 Type 2 Diabetes Mellitus, 7 Non-Diabetic Subjects, 4 , 6 Diabetic and Non-Diabetic Subjects, 3 , 9 PCI Patients With HbA1c 5.7% to 6.4 10 and Non-diabetic Patients with Acute Coronary Syndrome 5 . However, previous studies regarding the relationship between HbA1c and SYNTAX score just adjusted some conventional risk factor, not adjusted conventional cardiovascular drugs.…”

Evaluation of Myocardial Damage in Relation to HbA1c in Patients with Previously Unrecognized Diabetes Presenting with STEMI

“…There was no significant relationship between the Gensini score and HbA1c, fasting and postprandial blood glucose levels, lipid profile, and hs-CRP levels in patients with nondiabetic ACSs (35). HbA1c was not an independent predictor of the severity of CAD in non-diabetic adult patients (36).…”

Baseline high-sensitivity C-reactive protein and glycosylated hemoglobinA1c predict adverse outcomes in patients with chronic coronary syndromes undergoing percutaneous coronary intervention

“…A previous study demonstrated that an elevated HbA1c value could be used as a biomarker for predicting CAD [ 43 ]. Another study found that an elevated HbA1c value was an independent risk factor for mortality in non-diabetic patients with CAD [ 44 ]; however, a further study found that HbA1c was not an independent predictor of the severity of CAD in non-diabetic patients [ 45 ]. Yet another study found that the baseline HbA1c appeared to be an independent predictor of a poor prognosis in patients with CCS before and after adjustment for multiple covariates [ 30 ].…”