The Association between Hematological Parameters and Insulin Resistance Is Modified by Body Mass Index – Results from the North-East Italy MoMa Population Study

Barazzoni, Rocco; Cappellari, Gianluca Gortan; Semolic, A.; Chendi, Enrico; Ius, M.; Situlin, R.; Zanetti, Michela; Vinci, Pierandrea; Guarnieri, Gianfranco

doi:10.1371/journal.pone.0101590

Cited by 33 publications

(31 citation statements)

References 14 publications

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“…Barazzoni et al 32 reported that positive associations among BMI and RBC count, hemoglobin, and hematocrit were dependent on abdominal fat distribution and insulin resistance markers and that obesity per se was not associated with altered hematological parameters. In addition, Sinnapah et al 33 reported that increased RBC aggregation in patients with sleep apnea is caused by being overweight.…”

Section: Discussionmentioning

confidence: 99%

Association between lifestyle and hematological parameters: A study of Chinese male steelworkers

Jean

Hsu

Hung

et al. 2019

Clinical Laboratory Analysis

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BackgroundIncreasing evidence suggests an association between lifestyle and white blood cell (WBC) count; however, no study has examined the effects of lifestyle associations on hematological parameters. The aim of this study was to examine the association between lifestyle factors and hematological parameters in a large population‐based sample of Chinese male steelworkers.MethodsThis study included 3189 male workers at a steel plant who responded to a cross‐sectional questionnaire on basic attributes, lifestyle, and sleep. All workers in the plant underwent periodic health checkups. Hematological parameters were also examined at the checkup.ResultsStepwise linear regression analyses showed that smoking, poor sleep, shift work, and obesity were all significant factors associated with WBC count. Obesity was independently associated with RBC count. Furthermore, smoking and obesity were associated with hemoglobin, and smoking, poor sleep, and obesity were independently associated with hematocrit. Moreover, smoking was the main factor associated with MCV and MCH. When the subjects were divided into quartiles according to WBC count, RBC count, hemoglobin, hematocrit, MCV, MCH, and increased WBC count were associated with smoking, poor sleep, shift work, and obesity. Increased hemoglobin was associated with smoking and obesity. Furthermore, an increased RBC count was associated with obesity, and increased hematocrit was associated with smoking, poor sleep, and obesity. Similarly, increased MCV and MCH were also associated with smoking.ConclusionThis study indicates that lifestyle factors may exert an important effect on hematological parameters (eg, WBC count, RBC count, hemoglobin, hematocrit, MCV, and MCH).

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Section: Discussionmentioning

confidence: 99%

Association between lifestyle and hematological parameters: A study of Chinese male steelworkers

Jean

Hsu

Hung

et al. 2019

Clinical Laboratory Analysis

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“…Autores já haviam encontrado relação, porém negativa, de IMC e hemoglobina em sul-africanos; entretanto, encontrando relação positiva entre CC e hemoglobina 14 . Outros autores não encontraram relação da CC e do IMC com parâmetros hematológicos em italianos, mas após um ajuste com as variáveis sexo, idade e o hábito de fumar, encontraram uma relação positiva entre eles, o que foi atribuído à gordura abdominal e marcadores de resistência à insulina 6 . Um estudo encontrou uma relação positiva entre CC e hemácias, hemoglobina e hematócrito em americanos voluntários do US National Health and Nutrition Examination Survey (NHANES) 15 .…”

Section: Discussionunclassified

“…Há ainda, a coexistência de ambos estados nutricionais em uma única pessoa, resultado de uma dieta ricamente energética e pobre em micro e macro nutrientes, geralmente encontrada em pessoas carentes 5 . Apesar de não haver consenso entre os pesquisadores, de quais medidas antropométricas seriam positivamente associadas a indicadores hematológicos, há a certeza da importância da avaliação hematológica, junto à presença de obesidade, considerando que ambos influenciam no desenvolvimento de fatores de risco cardiometabólicos, tais como hipertensão e resistência à insulina [6][7] . Assim sendo, o presente estudo objetiva verificar possível associação entre o perfil hematológico e o estado nutricional de trabalhadores e seus filhos.…”

Section: Introductionunclassified

Relação Entre Indicadores Antropométricos E Hematológicos De Pais E Seus Filhos

et al. 2017

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RESUMOObjetivo: Verificar possível associação entre o perfil hematológico e o estado nutricional de trabalhadores e seus filhos. Metodologia: Estudo transversal composto por 25 pais e seus respectivos filhos (25). Avaliou-se índice de massa corporal (IMC), circunferência da cintura (CC), circunferência do quadril (CQ) e relação cintura-quadril (RCQ). Para os indicadores hematológicos, avaliou-se a hemoglobina e o hematócrito. Resultados: 13 pais e 6 filhos apresentam sobrepeso/obesidade e 9 pais e 3 filhos apresentam CC elevada. Entre os filhos, 11 apresentam hemoglobina aumentada e 7 hematócrito aumentado. Não foi observada relação entre os indicadores antropométricos e hematológicos de pais e seus filhos. Com relação aos pais, observou-se relação significativa entre RCQ com hemoglobina (p=0,002) e hematócrito (p=0,020). Entre os filhos, a CC associou-se com a hemoglobina (p=0,046) e com o hematócrito (p=0,016). Conclusão: Não foi encontrada relação dos indicadores antropométricos e hematológicos entre pais e filhos. Por outro lado, os indicadores antropométricos e hematológicos mostraram associação nos pais e nos filhos .Descritores: Anemia; Obesidade; Adulto; Criança; Adolescente. RELAÇÃO ENTRE INDICADORES ANTROPOMÉTRICOS E HEMATOLÓGICOS DE PAIS E SEUS FILHOS RELATIONSHIP BETWEEN ANTHROPOMETRIC AND HEMATOLOGICAL INDICATORS OF PARENTS AND THEIR CHILDRENABSTRACT Objective: To verify the possible association between hematological profile and nutritional status of workers and their children. Methodology: Cross-sectional study composed of 25 parents and their respective children (25). Body mass index (BMI), waist circumference (WC), hip circumference (HR) and waist-hip ratio (WHR) were evaluated. For hematological indicators, hemoglobin and hematocrit were evaluated. Results: 13 fathers and 6 children were overweight/obese and 9 fathers and 3 children had elevated WC. Among children, 11 have increased hemoglobin and 7 increased hematocrit. There was no relation between the anthropometric and hematological indicators of parents and their children. Regarding the parents, there was a significant relationship between WHR with hemoglobin (p = 0.002) and hematocrit (p = 0.020). Among children, CC was associated with hemoglobin (p = 0.046) and hematocrit (p = 0.016). Conclusion: No correlation was found between anthropometric and hematological indicators between parents and children.

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“…Blood cell count is a commonly used and widely available test method and is also associated with type 2 diabetes or obesity to some extent (16)(17)(18)(19) . In addition, in many studies, the use of Mg and serum Mg for disease treatment has been explored based on the relationship between Mg and blood cells (20)(21)(22)(23) .…”

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confidence: 99%

Association between serum magnesium and blood count: influence of type 2 diabetes and central obesity

Liu

et al. 2019

Br J Nutr

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The relationship between serum Mg and blood cell counts in Chinese adult diabetes or central obesity was assessed by investigating 8163 subjects with China Health and Nutrition Survey (mean age 59⋅6 years, 54⋅9 % men). Participants were classified according to blood Mg (below 0⋅65 mmol/l, or 0⋅66–0⋅94 mmol/l or above 0⋅95 mmol/l), type 2 diabetes (yes/no) and central obesity (yes/no). Leucocytes, erythrocytes, platelets (PLT), Hb and glycated Hb (HbA1c) were determined using standardised methods and conditions. HbAc1, leucocytes and PLT were significantly higher among subjects with central obesity than without central obesity (P < 0⋅05). A significant increase for Hb, erythrocytes, PLT, but not leucocytes, across progressive Mg groups was observed in subjects without diabetes (P < 0⋅05). Hb, erythrocytes and HbAc1 were significantly higher among subjects with higher Mg than in subjects with lower Mg with diabetes (P < 0⋅05). Central obesity disturbed the positive association between PLT count and serum Mg. Type 2 diabetes caused metabolism disorder in serum Mg, blood sugar and blood cell count. Hb, erythrocytes and PLT, but not leucocytes, are positively correlated with serum Mg, but this association is somehow disturbed by type 2 diabetes or central obesity.

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The Association between Hematological Parameters and Insulin Resistance Is Modified by Body Mass Index – Results from the North-East Italy MoMa Population Study

Cited by 33 publications

References 14 publications

Association between lifestyle and hematological parameters: A study of Chinese male steelworkers

Association between lifestyle and hematological parameters: A study of Chinese male steelworkers

Relação Entre Indicadores Antropométricos E Hematológicos De Pais E Seus Filhos

Association between serum magnesium and blood count: influence of type 2 diabetes and central obesity

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