The association between heavy metal exposure and erectile dysfunction in the United States

Wang, Wei; Xiang, Liyuan; Ma, Yucheng; Chen, Jiawei; Liao, Peng; Gao, Xiaoshuai; Zhang, Fu-Xun; Xiong, Yang; Qin, Feng; Yuan, Jing

doi:10.4103/aja202237

Cited by 5 publications

(5 citation statements)

References 39 publications

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“…According to the Massachusetts Male Aging Study, 19 all adult men were asked the following through a questionnaire on erectile function: “How would you describe your ability to obtain and maintain an erection sufficient for satisfactory sexual intercourse?” The answers included “always or almost always able,” “usually able,” “sometimes able,” and “never able.” According to the results of previous studies, 12 , 20 men who responded “sometimes able” or “never able” to maintain erectile function in our study were classified as having ED, while participants who responded “nearly always able” or “usually able” were classified as not having ED.…”

Section: Methodsmentioning

confidence: 60%

“… 21 BMI was classified as <20, 20 to <25, 25 to <30, and ≥30. 20 A person was regarded as a nonsmoker if one had never smoked >100 cigarettes in a lifetime. A person was deemed a current smoker if one had smoked >100 cigarettes and smoke daily or sometimes; the remaining participants were former smokers.…”

Section: Methodsmentioning

confidence: 99%

“…Participants who had been diagnosed with prostate disease were considered to have a history of prostate disease. 20 …”

Section: Methodsmentioning

confidence: 99%

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The association of various physical activities with erectile dysfunction: NHANES 2001-2004

Zhou

et al. 2023

Sexual Medicine

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Background The relationship between erectile dysfunction (ED) and physical activity has been established in several previous studies, but there is little information on the specific forms of activity that affect ED. Aim The objective of this study was to evaluate the relationship of 4 exercise categories and 2 activity intensities with ED in US men. Methods We used data sets from the National Health and Nutrition Examination Survey, 2001-2004. We used odds ratios (ORs) and multivariate logistic regression models to investigate the relationship between physical activity and ED. We also conducted subgroup analyses by age and controlled for potential confounder variables using propensity score matching analyses. Outcomes The primary outcome was ED as assessed through self-reporting. Results An overall 4094 adult men were included in the study. Adjusted multivariate regression models indicated that men who participated in monthly muscle-strengthening activities (OR = 0.75, P = .031), leisure activities (OR = 0.76, P = .024), or vigorous activities (OR = 0.64, P = .001) had a lower risk of ED. The subgroup analysis showed that among those ≥40 years old, muscle-strengthening activity (OR = 0.67, P = .005), leisure activity (OR = 0.72, P = .006), and vigorous activity (OR = 0.50, P < .001) were negatively associated with ED. After adjustment of propensity score matching, leisure activity and vigorous activity were also associated with a lower risk of ED, and muscle-strengthening activity was not significantly associated with ED. Clinical Implications Our findings could provide guidance to clinicians in helping patients with ED develop exercise programs. Strengths and Limitations We explored the relationship of 4 types and 2 intensities of exercise with ED, using a large sample size and sampling weights to produce representative data. However, this is only a cross-sectional study. Conclusion Active monthly participation in leisure and vigorous activity is associated with the maintenance of erectile function, while the relevance of muscle-strengthening activities needs further study.

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Section: Methodsmentioning

confidence: 60%

Section: Methodsmentioning

confidence: 99%

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The association of various physical activities with erectile dysfunction: NHANES 2001-2004

Zhou

et al. 2023

Sexual Medicine

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“…Before reaching the age of 40, ED prevalence ranges from 1% to 10%. Beyond 40 years, the occurrence of ED escalates dramatically to 52% ( 2 ), and an alarming 70% of men aged 70 and above contend with ED ( 3 ). Notably, Ayta IA underscored an upward trajectory in ED prevalence, projecting that over 322 million men worldwide will grapple with ED by 2025 ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Correlation between visceral fat metabolism score and erectile dysfunction: a cross-sectional study from NHANES 2001-2004

Huang,

Liu,

et al. 2023

Front. Endocrinol.

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BackgroundsThe factors associated with erectile dysfunction (ED) are diverse, and obesity is a significant component. Metabolic Score for Visceral Fat (METS-VF) can assess obesity more accurately than body mass index (BMI). However, the association between METS-VF and ED remains unclear.ObjectiveThis study aimed to investigate the association between the METS-VF and ED using National Health and Nutrition Examination Survey (NHANES) 2001-2004 data.MethodsData were sourced from NHANES 2001-2004. The relationship between METS-VF and ED was analyzed using multivariate logistic regression, followed by subgroup analyses to identify sensitive populations. Nonlinear correlation was evaluated through smoothed curve fitting, and a threshold effect analysis validated the findings. Comparative logistic regression of the Receiver Operating Characteristic (ROC) curve assessed the diagnostic capability of METS-VF against the classical obesity index for ED.ResultsThe study enrolled 3625 participants, of whom 961 self-reported ED history and 360 reported severe ED. After adjusting for confounders, METS-VF exhibited a positive association with asthma prevalence (OR= 3.47, 95% CI: 2.83, 14.24). Stratification based on median METS-VF revealed higher ED prevalence in participants with elevated METS-VF (OR= 2.81,95% CI:2.32, 3.41). Nonlinear correlation was observed, with a significant association between METS-VF and ED when METS-VF exceeded 6.63. Subgroup analysis highlighted a stronger correlation in participants aged 50-85 years, Caucasians, hypertensive individuals, diabetics, and those with coronary heart disease. Sensitivity analysis using severe ED as the outcome reaffirmed the nonlinear positive association with METS-VF (OR=3.86, 95% CI:2.80,5.33), particularly when METS-VF surpassed 6.68.ConclusionElevated METS-VF was nonlinearly correlated with increased ED incidence. Individuals with METS-VF above 6.63 should be vigilant about heightened ED risk. Special attention should be given to participants aged 50-85 years, Caucasians, hypertensive individuals, diabetics, and those with coronary heart disease.

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“…Among the risk factors, heavy metal exposure such as cadmium has gradually attracted researchers' attention. It has been reported that heavy metal exposure can increase the risk of urinary diseases such as erectile dysfunction, kidney stone diseases, and prostate cancer (7)(8)(9). However, the role of cadmium in the risk of renal stones is less investigated.…”

mentioning

confidence: 99%

National analysis of urinary cadmium concentration and kidney stone: Evidence from NHANES (2011–2020)

Zai-zhi

Luo

et al. 2023

Front. Public Health

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BackgroundThe association between urinary cadmium and kidney stone risk is inconsistent in previous studies, which needs further exploration. This study was performed to explore the association between urinary cadmium and kidney stone.Materials and methodsData from the National Health and Nutrition Examination Survey (2011–2020) were included and further analyzed. Urinary cadmium was stratified into quartiles with quartile 1 (Q1: 0.025–0.104 μg/L) and quartile 4 (Q4: 0.435–7.581 μg/L). Further weighted logistic regression was adopted to evaluate the association between urinary cadmium and kidney stone. A subgroup analysis was used to verify the findings. The non-linear association was examined using the restricted cubic spline (RCS) regression.ResultsA total of 9,056 adults aged 20 years and above were included in this study. In the fully adjusted model, an increased risk of kidney stones was identified for quartile 2 (OR = 1.40, 95% CI = 1.06–1.84, P < 0.05), quartile 3 (OR = 1.18, 95% CI = 0.88–1.59, P > 0.05), and quartile 4 (OR = 1.54, 95% CI = 1.10–2.06, P < 0.05). A similar association was found between continuous cadmium increase and OR of kidney stones in the fully adjusted model (OR = 1.13, 95% CI = 1.01–1.26, P < 0.05). The RCS also indicated a non-linear association between urinary cadmium concentration and kidney stone risk (P for non-linear < 0.001).ConclusionIn summary, cadmium exposure is identified as a risk factor for kidney stones in this study. Their non-linear association makes demands on early intervention for the cadmium-exposed population. Medical interventions for kidney stone prevention should take cadmium exposure into account.

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The association between heavy metal exposure and erectile dysfunction in the United States

Cited by 5 publications

References 39 publications

The association of various physical activities with erectile dysfunction: NHANES 2001-2004

The association of various physical activities with erectile dysfunction: NHANES 2001-2004

Correlation between visceral fat metabolism score and erectile dysfunction: a cross-sectional study from NHANES 2001-2004

National analysis of urinary cadmium concentration and kidney stone: Evidence from NHANES (2011–2020)

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