The Association Between Glycolyzed Hemoglobin A1c and Hearing Loss in Diabetic Patients

Elibol, Elif; Baran, Hacer

doi:10.7759/cureus.10254

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…Findings of current research was comparable to the previous studies. [19,20] In group I 18 (45%) patients were smokers and in group II 15 (27.5%) were smokers. [21] As a result of microvascular problems, the high-frequency specific regions of the cochlea may be more sensitive to ischemia alterations [22] resulting in diabetes-related hearing loss.…”

Section: Discussionmentioning

confidence: 94%

Hearing Loss in Diabetic Patients Linked with Glycolyzed Hemoglobin A1C

Afzal¹,

Aslam²,

Ali³

2022

PJMHS

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Objective: Glycolyzed haemoglobin A1c (HbA1c) and hearing loss in diabetic individuals are the primary goals of the present research. Study Design: Randomized Case Control Place and Duration: THQ Hospital Kamalia. Aug 2021 to Feb 2022. Methods: There were 80 patients of both genders with ages 16-75 years were presented. Detailed demographics of enrolled cases included age, sex, body mass index and comorbidities were recorded after taking informed written consent. Patients were divided in two groups. Group I had 40 diabetic patients and group II had 40 non-diabetic patients. Hearing loss among both groups was compared by different glycolized hemoglobin levels. SPSS 25.0 was used to analyze complete data. Results: There were 32 (80%) males and 8 (20%) female in group I and in group II 24 (60%) males and 16 (40%) females. Mean age in group I was 41.31±5.81 years and had men BMI 24.13±7.15 kg/m2 while in group II mean age was 39.11±4.28 years with mean BMI 22.17±11.32 kg/m2. In group I 18 (45%) patients were smokers and in group II 15 (27.5%) were smokers. Frequency of hearing loss in group I was higher found in 23 (57.5%) patients as compared to non-diabetic patients in only 2 (5%). Frequency of tinnitus, vertigo and dizziness were also significantly higher in diabetic patients with p value <0.05. Conclusion: Patients with diabetes mellitus may suffer from impaired hearing and balance even if they do not show any symptoms. As a result, early rehabilitative care should be established to prevent future difficulties. Keywords: Diabetes Mellitus, Hearing Loss, Hemoglobin A1c

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Section: Discussionmentioning

confidence: 94%

Hearing Loss in Diabetic Patients Linked with Glycolyzed Hemoglobin A1C

Afzal¹,

Aslam²,

Ali³

2022

PJMHS

View full text Add to dashboard Cite

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“…Cardiovascular factors, such as dyslipidemia and hypertension, have a complex association with noise exposure and hearing loss; however, studies are inconsistent and oftentimes contradictory . The microvascular consequences of diabetes include hearing loss, with known associations between hyperglycemia and glycohemoglobin levels with hearing loss . Other metabolic factors that may be associated with the ramifications of stress, such as body mass index, have also shown similar associations with hearing loss .…”

Section: Discussionmentioning

confidence: 99%

“…[41][42][43] The microvascular conse- quences of diabetes include hearing loss, with known associations between hyperglycemia and glycohemoglobin levels with hearing loss. [44][45][46] Other metabolic factors that may be associated with the ramifications of stress, such as body mass index, have also shown similar associations with hearing loss. 47 Lastly, systemic inflammatory biomarkers, including C-reactive protein levels, have an unclear association with hearing, with associations noted only stratifying by age.…”

Section: Discussionmentioning

confidence: 99%

Hearing Impairment and Allostatic Load in Older Adults

Jiang

Reed

et al. 2023

JAMA Otolaryngol Head Neck Surg

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ImportanceAllostatic load, the cumulative strain that results from the chronic stress response, is associated with poor health outcomes. Increased cognitive load and impaired communication associated with hearing loss could potentially be associated with higher allostatic load, but few studies to date have quantified this association.ObjectiveTo investigate if audiometric hearing loss is associated with allostatic load and evaluate if the association varies by demographic factors.Design, Setting, ParticipantsThis cross-sectional survey used nationally representative data from the National Health and Nutrition Examination Survey. Audiometric testing was conducted from 2003 to 2004 (ages 20-69 years) and 2009 to 2010 (70 years or older). The study was restricted to participants aged 50 years or older, and the analysis was stratified based on cycle. The data were analyzed between October 2021 and October 2022.ExposureA 4-frequency (0.5-4.0 kHz) pure tone average was calculated in the better-hearing ear and modeled continuously and categorically (&lt;25 dB hearing level [dB HL], no hearing loss; 26-40 dB HL, mild hearing loss; ≥41 dB HL, moderate or greater hearing loss).Main Outcome and MeasuresAllostatic load score (ALS) was defined using laboratory measurements of 8 biomarkers (systolic/diastolic blood pressure, body mass index [calculated as weight in kilograms divided by height in meters squared], and total serum and high-density lipoprotein cholesterol, glycohemoglobin, albumin, and C-reactive protein levels). Each biomarker was assigned a point if it was in the highest risk quartile based on statistical distribution and then summed to yield the ALS (range, 0-8). Linear regression models adjusted for demographic and clinical covariates. Sensitivity analysis included using clinical cut points for ALS and subgroup stratification.ResultsIn 1412 participants (mean [SD] age, 59.7 [5.9] years; 293 women [51.9%]; 130 [23.0%] Hispanic, 89 [15.8%] non-Hispanic Black, and 318 [55.3%] non-Hispanic White individuals), a modest association was suggested between hearing loss and ALS (ages 50-69 years: β = 0.19 [95% CI, 0.02-0.36] per 10 dB HL; 70 years or older: β = 0.10 [95% CI, 0.02-0.18] per 10 dB HL) among non–hearing aid users. Results were not clearly reflected in the sensitivity analysis with clinical cut points for ALS or modeling hearing loss categorically. Sex-based stratifications identified a stronger association among male individuals (men 70 years or older: β = 0.22 [95% CI, 0.12-0.32] per 10 dB HL; women: β = 0.08 [95% CI, −0.04 to 0.20] per 10 dB HL).Conclusion and RelevanceThe study findings did not clearly support an association between hearing loss and ALS. While hearing loss has been shown to be associated with increased risk for numerous health comorbidities, its association with the chronic stress response and allostasis may be less than that of other health conditions.

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Hearing impairment in relation to vitamin D status in type 2 diabetic patients: A cross-sectional study

Elhussieny,

Eladawy,

Ahmad

et al. 2023

ELECTRON J GEN MED

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Objectives: To evaluate the association of serum 25 hydroxy vitamin D (25OHD) and hearing impairment type 2 diabetes mellitus (T2DM) patients. In addition, we aimed to examine whether T2DM-associated hearing impairment is correlated with the severity of diabetes. Methods: The present case-control study recruited adult patients with T2DM and healthy controls. Using pure-tone stimuli, we used an audiometer to assess the hearing thresholds of air conduction in each ear separately. Results: 84 patients and 32 volunteers were included. The serum 25OHD was lower in T2DM patients than in healthy control (12.24±1.3 versus 23.19±5.69, respectively; p<0.001). The prevalence of vitamin D deficiency was 100% in the T2DM group, compared to 25% in the control group (p=0.001). T2DM patients exhibited higher hearing thresholds at all tested frequencies compared to the control group (p<0.001). Diabetic patients with hearing impairment had a significantly lower serum 25OHD than the normal hearing group (11.7±1.2 versus 12.6±1.2 ng/d; p=0.02). The multivariate analysis demonstrated that serum 25OHD level was an independent predictor of hearing loss among diabetic patients (β=-0.605; p=0.041). Conclusions: the present study highlights the potential role of vitamin D deficiency in developing hearing impairment in the setting of T2DM. We found a negative correlation between serum 25OHD level and air conduction thresholds at low-mid and high frequencies amongst patients with T2DM.

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The Association Between Glycolyzed Hemoglobin A1c and Hearing Loss in Diabetic Patients

Cited by 3 publications

References 17 publications

Hearing Loss in Diabetic Patients Linked with Glycolyzed Hemoglobin A1C

Hearing Loss in Diabetic Patients Linked with Glycolyzed Hemoglobin A1C

Hearing Impairment and Allostatic Load in Older Adults

Hearing impairment in relation to vitamin D status in type 2 diabetic patients: A cross-sectional study

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