The association between gestational diabetes and postpartum depression: A systematic review and meta-analysis

Azami, Milad; Badfar, Gholamreza; Soleymani, Ali; Rahmati, Shoboo

doi:10.1016/j.diabres.2019.01.034

Cited by 92 publications

(96 citation statements)

References 32 publications

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“…In the postpartum, the prevalence of depression in women diagnosed with GDM during pregnancy was 13% (pooled OR 1.59). This is similar to a recent meta-analysis which found a pooled relative risk for postnatal depression in women with GDM of 1.59 [9]. However, the studies included in the two reviews differ slightly, due to stricter inclusion and exclusion criteria in our review, such as ensuring the exclusion of pregestational diabetes from control groups and also a more recent literature search in our study.…”

Section: Main Findingssupporting

confidence: 88%

Is there an increased risk of perinatal mental disorder in women with gestational diabetes? A systematic review and meta‐analysis

et al. 2019

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Aim Gestational diabetes (GDM) and mental disorder are common perinatal morbidities and are associated with adverse maternal and child outcomes. While there is a relationship between type 2 diabetes and mental disorder, the relationship between GDM and mental disorder has been less studied. We conducted a systematic review and meta‐analysis of the prevalence of mental disorders in women with GDM and their risk for mental disorders compared with women without GDM. Methods Published, peer‐reviewed literature measuring prevalence and/or odds of GDM and perinatal mental disorders was reviewed systematically. Risk of bias was assessed using a checklist. Two independent reviewers were involved. Analyses were grouped by stage of peripartum, i.e. antepartum at the time of GDM diagnosis and after diagnosis, and in the postpartum. Results Sixty‐two studies were included. There was an increased risk of depressive symptoms in the antenatal period around the time of diagnosis of GDM [odds ratio (OR) 2.08; 95% confidence interval (CI) 1.42, 3.05] and in the postnatal period (OR 1.59; 95% CI 1.26, 2.00). Conclusions Given the potential relationship between GDM and perinatal mental disorders, integration of physical and mental healthcare in women experiencing GDM and mental disorders could improve short‐ and long‐term outcomes for women and their children.

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Section: Main Findingssupporting

confidence: 88%

Is there an increased risk of perinatal mental disorder in women with gestational diabetes? A systematic review and meta‐analysis

et al. 2019

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“…A prior meta-analysis estimated that GDM significantly increased the risk of postpartum depression by a pooled RR ranging from 1.32 to 1.59 [29,30]. Meanwhile, we estimated that the association between GDM and risk of antepartum depression was statistically significant at with a pooled RR at 1.43.…”

Section: Discussionmentioning

confidence: 85%

“…On the other hand, most of the existing literature focused on the association between DIP and postpartum depression, for example a meta-analysis by Arafa and Dong [29] that reported that GDM is a significant risk factor for postpartum depression (pooled relative risk (RR) = 1.32). Another meta-analysis by Azami et al found a similar pooled RR of 1.59 based on observational studies [30]. Indeed, postpartum depression has a drawn out ramifications for women and their children [31].…”

Section: Introductionmentioning

confidence: 89%

Diabetes in Pregnancy and Risk of Antepartum Depression: A Systematic Review and Meta-Analysis of Cohort Studies

Lee

Ching

Chong

et al. 2020

IJERPH

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Previous literature has reported that patients with diabetes in pregnancy (DIP) are at risk of developing antepartum depression but the results have been inconsistent in cohort studies. We conducted a systematic review and performed a meta-analysis to quantify the association between DIP and risk of antepartum depression in cohort studies. Medline, Cinahl, and PubMed databases were searched for studies investigating DIP involving pregnant women with pre-existing diabetes and gestational diabetes mellitus and their risk of antepartum depression that were published in journals from inception to 27 December 2019. We derived the summary estimates using a random-effects model and reported the findings as pooled relative risks (RR) and confidence interval (CI). Publication bias was assessed using a funnel plot and was quantified by Egger and Begg’s tests. Ten studies, involving 71,036 pregnant women were included in this meta-analysis. The pooled RR to develop antepartum depression was (RR = 1.430, 95% CI: 1.251–1.636) among women with gestational diabetes mellitus. Combining pregnant women with pre-existing diabetes mellitus and gestational diabetes mellitus, they had a significant increased risk of developing antepartum depression (RR = 1.431, 95% CI: 1.205–1.699) compared with those without it. In comparison, we found no association between pre-existing diabetes mellitus in pregnancy (RR = 1.300, 95% CI: 0.736–2.297) and the risk of developing antepartum depression. This study has a few limitations: first, different questionnaire and cut-off points were used in evaluation of depression across the studies. Second, there was a lack of data on history of depression prior to pregnancy, which lead to confounding bias that could not be solved by this meta-analysis. Third, data were dominated by studies in Western countries; this is due to the studies from Eastern countries failing to meet our inclusion criteria for statistical analysis. Women with gestational diabetes mellitus have an increased risk of developing antepartum depression compared to those without the disease. Therefore, more attention on the mental health status should be given on pregnant women diagnosed with pre-existing diabetes mellitus and gestational diabetes mellitus.

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“…Evidence shows that depression and anxiety during pregnancy have adverse effects on the foetus, such as intrauterine growth restriction and preterm birth, poorer child neurodevelopment, among other complications for the baby (6,7), as well as preeclampsia, arterial hypertension (8) in the mother. It is also recognized as an association between gestational diabetes and postpartum depression (9). Even more, pregnancy depression may lead to long-lasting or permanent mood disorders throughout life (10).…”

Section: Introductionmentioning

confidence: 99%

Mexican pregnant women show higher depression and anxiety with rising age and in the case of being single

Salgado

Mendoza

Zerón

2020

AML

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Background. Pregnancy is an important predisposition period to develop anxiety and depression, with a direct impact on the woman’s offspring. The aim of this study was to report the correlation between depression and anxiety in pregnant women and its association with the marital status and age. Materials. A descriptive, retrospective and cross-sectional study was conducted in the outpatient care of the Psychology Service at the “Mónica Pretelini Sáenz” Maternal Perinatal Hospital (HMPMPS), Toluca, Mexico, from June 2012 to March 2019. As routine, the Beck Depression Inventory (BDI-II) and the Beck Anxiety Inventory-Trait (BAIT), were applied to all women seeking attention at the HMPMPS. Only pregnant patients were selected for this study, with the women referred for the first time to the external Psychology Clinic as inclusion criteria. Pearson’s correlation coefficient and the frequency of cases for age, BDI-II, and BAIT were obtained using the IBM SPSS Statistics ® v.23 software. Results. The study included 2947 pregnant patients with a mean age of 28.6 ± 6.9 years. Of these, 2616 (88.8%) presented with mild anxiety, 269 (9.1%) with moderate, and 62 (2.1%) with severe anxiety. On the other hand, 2149 (72.9%) patients presented with minimal depression, 341 (11.6%) mild depression, 268 (9.1%) moderate depression, and 189 (6.4%) had severe depression. The correlations between age and BDI-II was –0.026 (P = 0.152), between age and BAI was –0.038 (P = 0.037), and between BAIT and BDI-II 0.650 (P ≤ 0.001). Conclusions. The age group with the highest frequency of depression and anxiety was from 20 to 29 years. The absence of a stable partner represented an important risk factor for anxiety and depression during pregnancy.

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The association between gestational diabetes and postpartum depression: A systematic review and meta-analysis

Cited by 92 publications

References 32 publications

Is there an increased risk of perinatal mental disorder in women with gestational diabetes? A systematic review and meta‐analysis

Is there an increased risk of perinatal mental disorder in women with gestational diabetes? A systematic review and meta‐analysis

Diabetes in Pregnancy and Risk of Antepartum Depression: A Systematic Review and Meta-Analysis of Cohort Studies

Mexican pregnant women show higher depression and anxiety with rising age and in the case of being single

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