The association between follicle size and oocyte development as a function of final follicular maturation triggering

Mohr–Sasson, Aya; Orvieto, Raoul; Blumenfeld, Shlomit; Axelrod, Michal; Mor-Hadar, Danielle; Grin, Leonti; Aizer, Adva; Haas, Jigal

doi:10.1016/j.rbmo.2020.02.005

Cited by 23 publications

(21 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our previous study (8), we demonstrated higher oocyte recovery rate in large (≥ 16 mm) and medium (13-15 mm) large compared to the small (< 13 mm) follicle groups, finding which is consistent with previous studies (2,11,12,13). Moreover, MII oocytes were more commonly found in the medium and large follicle groups (8,11,14).…”

Section: Discussionmentioning

confidence: 99%

“…The subgroup analysis which we present here was not planned in theoriginal protocol. The cut-off to be analyzed was chosen, after completion of the original trial (8).…”

Section: Methodsmentioning

confidence: 99%

“…Recently, we demonstrated in a cohort prospective study (8) evaluating the association between follicle size (maximal dimensional size: large: ≥16 mm, medium: 15 to 13 mm, and small: <13 mm) and oocyte/embryo quality, that mature oocyte (MII) rate was significantly higher in the large and medium compared to the small follicle size groups. Nevertheless, no in-between group differences were observed in fertilization nor in top quality embryo (TQE) rates among the mature oocytes regardless the follicular diameter they originated.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Does large (>24mm) follicle yield a competent oocyte/embryo?

Orvieto

Mohr–Sasson

Blumenfeld

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Aim: To evaluate the effect of large follicular size ( > 24mm) at day of oocyte retrieval on oocyte/embryo quality. Patients and Methods: A cohort study conducted in a single tertiary medical center between July 2018 and May 2019. Before ultrasound-guided follicular aspiration, follicles were measured and divided into two groups according to their maximal dimensional size: large: ≥24 mm and normal: <24 mm. Microscopic examination of the follicular aspirates was performed by embryologist. Each follicle aspirated was evaluated for oocyte maturation, oocyte fertilization and embryo quality. Results: 428 follicles were measured, including 383 (62.81%) in the normal and 45 (14.06%) in the large follicle groups. Oocytes were achieved during aspiration from 297 (75.5%) and 29 (64.4%) of the normal and large follicle groups, respectively (p=0.05). No in-between group differences were observed in mature oocyte (MII), fertilization and top quality embryo (TQE) rates. Nevertheless, once a zygote (2PN) was achieved, a trend toward a higher TQE rate/2PN was found in the large follicle group [16 /19 (84.2%) vs. 115/171 (67.3%); p=0.062]. Conclusion: While a non-significant decrease in oocyte recovery rate was found in follicles ≥24 mm, the zygote and TQE per follicles were comparable.** Drs. Orvieto and Mohr-Sasson should be considered "similar in author order."

show abstract

Section: Discussionmentioning

confidence: 99%

“…The subgroup analysis which we present here was not planned in theoriginal protocol. The cut-off to be analyzed was chosen, after completion of the original trial (8).…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Does large (>24mm) follicle yield a competent oocyte/embryo?

Orvieto

Mohr–Sasson

Blumenfeld

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Previous data summarized that the optimal follicle size on the day of oocyte retrieval that is most likely to yield a mature oocyte is 16-22 mm [1], and the optimal sized follicles are more likely to yield mature oocytes than smaller follicles [2]. Recently, we demonstrated in a prospective cohort study [3] evaluating the association between follicle size (maximal dimensional size: large: ≥16 mm, medium: 15-13 mm, and small: <13 mm) and oocyte/embryo quality that mature oocyte (MII) rate was significantly higher in the large and medium follicle size groups compared with the small follicle size group. Nevertheless, no in-between group differences were observed in fertilization nor in top quality embryo (TQE) rates among the mature oocytes regardless the follicular diameter they originated.…”

Section: Introductionmentioning

confidence: 88%

“…We therefore evaluated the competency of oocytes/embryos derived from follicles >15 mm in diameter from obese patients, compared with nonobese patients. For this purpose, we reanalyzed the data from our previously published cohort prospective study [3].…”

Section: Introductionmentioning

confidence: 99%

Do Follicles of Obese Patients Yield Competent Oocytes/Embryos?

Orvieto

Mohr–Sasson

Aizer

et al. 2020

Gynecol Obstet Invest

Self Cite

View full text Add to dashboard Cite

Aim: This study evaluated the competency of oocytes/embryos derived from follicles >15 mm in diameter from obese patients, compared with nonobese patients. Patients and Methods: A cohort study was conducted in a single tertiary medical center between July 2018 and May 2019. Before ultrasound-guided follicular aspiration, follicles were measured and those with maximal dimensional size >15 mm were tracked. Microscopic examination of the follicular aspirates was performed by an embryologist. Each follicle aspirated was evaluated for oocyte maturation, oocyte fertilization, and embryo quality. Results: 457 follicles were measured: 380 (83.2%) in nonobese and 77 (16.8%) in obese patients. No in-between group differences were observed in the causes of infertility, patients’ demographics, or ovarian stimulation characteristics. Oocytes were achieved during aspiration from 277 (72.8%) and 54 (70.0%) of the nonobese and obese groups, respectively (p = 0.67). No in-between group differences were observed in fertilization (2PN/oocyte), top quality embryo (TQE) per zygote (2PN), and TQE per follicle. Conclusion: Oocyte recovery rate from follicles >15 mm is unrelated to patients’ BMI. Moreover, the oocytes recovered from obese patients are competent yielding comparable zygote and TQE per follicle/oocyte, compared with nonobese patients. Further investigation is required to strengthen this finding.

show abstract