The association between fatigue and apathy in patients with either Parkinson's disease or multiple sclerosis

Cochrane, Graham D.; Rizvi, Syed; Abrantes, Ana M.; Crabtree, Brigid; Cahill, Jonathan; Friedman, Joseph H.

doi:10.1016/j.parkreldis.2015.07.007

Cited by 28 publications

(30 citation statements)

References 18 publications

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“…It may be associated with many activities, such as exercise, aging, tumor growth, multiple sclerosis and Parkinson's disease (17)(18)(19). In particular, physical fatigue induced by strenuous exercise is thought to lead to a deterioration in performance, causing a decrease in muscular power and endurance, as well as in mental functions (20,21).…”

Section: Introductionmentioning

confidence: 99%

Nigella sativa seed extract attenuates the fatigue induced by exhaustive swimming in rats

Rahman

Yang

Kim³

et al. 2017

Biomedical Reports

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Abstract. In previous studies, Nigella sativa (NS) has been studied due to its various physiological and pharmacological activities. However, evidence on the effects of NS on physical fatigue following exhaustive swimming remains limited. In the present study, the authors evaluated the potential beneficial effects of NS against the fatigue activity following exhaustive swimming. Rats were orally administered with NS extract (2 g/kg/day) for 21 days, and the anti-fatigue effect was assessed by exhaustive swimming exercise. The presented results indicated that pre-treatment of NS extract significantly increased the time to exhaustion. In hemodynamic parameters, NS extract increased blood pO 2 and O 2sat , but decreased pCO 2 . For underlying mechanisms, NS extract protected depletion of energy, indicated by increased levels of blood pH, glucose and tissue glycogen contents, and decreased levels of blood lactate, tissue lactic dehydrogenase and creatine kinase, when the NS extract was pre-treated. In addition, the NS extract inhibited oxidative stress following exhaustive swimming, as reflected by the results of increased levels of superoxide dismutase and redox ratio, and decreased the level of malondialdehyde when the NS extract was pre-treated. Collectively, the present study demonstrated that NS extract has an anti-fatigue activity against exhaustive swimming by energy restoration and oxidative-stress defense.

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Section: Introductionmentioning

confidence: 99%

Nigella sativa seed extract attenuates the fatigue induced by exhaustive swimming in rats

Rahman

Yang

Kim³

et al. 2017

Biomedical Reports

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show abstract

“…In fact, ultrasound imaging in the shoulder region in 33 PD patients found abnormalities in 22 (66.6%), including tendon tearing, the supraspinatus muscle being the most common site involved 18 . Fatigue and asthenia can be observed in the initial stages of PD and may be related to the combination of RA syndrome and apathy, fatigue and depression 19 . Rhinorrhea unrelated to allergy, sinus disease or respiratory tract infections can occur in PD patients 20 .…”

Section: Discussionmentioning

confidence: 99%

Unusual motor and non-motor symptoms and signs in the early stage of Parkinson’s disease

Teive

Filho

Munhoz³

2016

Arq. Neuro-Psiquiatr.

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Objective Patients with Parkinson’s disease (PD) may present with unusual motor and non-motor symptoms and signs in the early stage of the disease. Methods Cases were collected over a five-year period at two tertiary movement disorders clinics. All had a diagnosis of PD with unusual presentations defined retrospectively as the presence of complaints not objectively related to any of the classic cardinal signs of parkinsonism or the typical early non-motor features of PD. Results A total of 15 early PD patients fulfilled the proposed criteria, presenting with symptoms such as atypical tremors, shoulder pain, signs related to the rigid akinetic syndrome, as well as cases of asthenia, rhinorrhea, parosmia, dysgeusia, nocturnal sialorrhea, and color discrimination disorders. Conclusions Unusual motor and non-motor symptoms and signs in the early stage of PD can be difficult to interpret. Specialists should be aware of these conditions as clues to a potential diagnosis.

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“…33 Despite the limited number of randomized controlled trials showing a benefit of exercise for fatigue thus far, we would still recommend exercise as part of the treatment regimen for fatigue, as it has benefits on other aspects of PD and because PD patients often feel that exercise alleviates fatigue. 73 …”

Section: Non-pharmacologic Therapiesmentioning

confidence: 99%

Managing fatigue in patients with Parkinson's disease: a patient-focused perspective

Ridder¹,

Chou²

2016

JPRLS

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The association between fatigue and apathy in patients with either Parkinson's disease or multiple sclerosis

Cited by 28 publications

References 18 publications

Nigella sativa seed extract attenuates the fatigue induced by exhaustive swimming in rats

Nigella sativa seed extract attenuates the fatigue induced by exhaustive swimming in rats

Unusual motor and non-motor symptoms and signs in the early stage of Parkinson’s disease

Managing fatigue in patients with Parkinson's disease: a patient-focused perspective

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The association between fatigue and apathy in patients with either Parkinson's disease or multiple sclerosis

Cited by 28 publications

References 18 publications

Nigella sativa seed extract attenuates the fatigue induced by exhaustive swimming in rats

Nigella sativa seed extract attenuates the fatigue induced by exhaustive swimming in rats

Unusual motor and non-motor symptoms and signs in the early stage of Parkinson’s disease

Managing fatigue in patients with Parkinson&#39;s disease: a patient-focused perspective

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Resources

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Managing fatigue in patients with Parkinson's disease: a patient-focused perspective