The association between fasting plasma glucose and all‐cause and cause‐specific mortality by gender: The rural Chinese cohort study

Abstract

Background:To evaluate the association between fasting plasma glucose (FPG) and mortality by gender.Methods: A total of 17 248 eligible participants from a rural Chinese prospective cohort population were included. The same questionnaire interview and anthropometric and laboratory measurements were performed at both baseline (2007)(2008) and follow-up (2013-2014). Participants were classified according to baseline FPG and diabetic status by sex. Restricted cubic splines and Cox proportional-hazards regression models, estimating hazard ratio (HR) and 95% confidence interval (CI), were used to assess the FPG-mortality relation. Results: During the 6-year follow-up, 618 men and 489 women died. The FPGmortality relation was J shaped for both sexes. For men, risk of all-cause and noncardiovascular disease (CVD)/noncancer mortality was greater with low fasting glucose (LFG) than with normal fasting glucose (adjusted HR [aHR] 1.60; 95% CI, 1.05-2.43; and aHR 2.16; 95% CI, 1.15-4.05). Men with diabetes mellitus (DM) showed increased risk of all-cause (aHR 2.04; 95% CI, 1.60-2.60), CVD (aHR 1.98; 95% CI, 1.36-2.89), and non-CVD/noncancer mortality (aHR 2.62; 95% CI, 1.76-3.91). Men with impaired fasting glucose (IFG) had borderline risk of CVD mortality (aHR 1.34; 95% CI, 1.00-1.79). Women with LFG had increased risk of non-CVD/ noncancer mortality (aHR 2.27; 95% CI, 1.04-4.95), and women with DM had

Fasting glucose level and all-cause or cause-specific mortality in Korean adults: a nationwide cohort study

“…Previous studies investigating associations between FG and the risk of all-cause mortality have reported J-shaped relationships, and our findings are in agreement with the cohort studies in earlier literature [4,23,24]. In our results, we noted this pattern in various categories of cause-specific mortality, in men and women, except in the case of cardiovascular deaths (Fig.…”

“…For this reason, fasting glucose (FG) is a useful indicator for screening and diagnosing diabetes mellitus. Additionally, it has recently been reported that an increased risk of mortality was associated with FG levels in a population-based study [4][5][6]. According to the literature, low https://doi.org/10.3904/kjim.2019.355…”

“…2020 Jul 7. [Epub ahead of print] or high levels of FG have been linked with an increased risk of all-cause and cause-specific mortality, indicating a J-or U-shaped relationship between FG and mortality [4,[7][8][9]. However, existing studies have been limited in that they have been mainly focused on the risk of cardiovascular mortality [6][7][8], and when classifying cause-specific mortality, the causes of death were not adequately diverse, improper categories for all-cause and cause-specific mortality were defined, or unnatural deaths were included [4][5][6]9,10].…”

“…The risks of all-cause and cause-specific mortality vary according to sex, race, and the region in which people live [4,11]. Recent findings have suggested ethnicity-dependent responses to insulin sensitivity, β-cell function, physical exercise, and lifestyle, which may lead to inconsistent outcomes [12][13][14].…”

Association between prediabetes and risk of all cause mortality and cardiovascular disease: updated meta-analysis

“…Thirdly, in most of the included studies, people with low blood glucose concentrations were not excluded. Some studies have shown that the association of fasting plasma glucose concentrations with cardiovascular disease has a J shaped curve 525354. The inclusion of people with low blood glucose concentrations in the reference group would make the association of prediabetes and risk towards null.…”