The Association Between Family History and Diverticulitis Recurrence: A Population-Based Study

Horns, Joshua J.; Hanson, Heidi A.; Allen‐Brady, Kristina; Kieffer, Madison; Huang, Lyen C.; Brooke, Benjamin S.

doi:10.1097/dcr.0000000000002178

Cited by 3 publications

(2 citation statements)

References 39 publications

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“…This was most notable in those with a first-degree family member affected by diverticulitis (HR 1.7; 95% c.i. 1.4 to 2.2) 30 .…”

Section: Epidemiologymentioning

confidence: 99%

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Genetic, epigenetic and environmental factors in diverticular disease: systematic review

Humphrey,

Sibley,

Walker

et al. 2024

BJS Open

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Background Diverticulosis is a normal anatomical variant of the colon present in more than 70% of the westernized population over the age of 80. Approximately 3% will develop diverticulitis in their lifetime. Many patients present emergently, suffer high morbidity rates and require substantial healthcare resources. Diverticulosis is the most common finding at colonoscopy and has the potential for causing a significant morbidity rate and burden on healthcare. There is a need to better understand the aetiology and pathogenesis of diverticular disease. Research suggests a genetic susceptibility of 40–50% in the formation of diverticular disease. The aim of this review is to present the hypothesized functional effects of the identified gene loci and environmental factors. Methods A systematic literature review was performed using PubMed, MEDLINE and Embase. Medical subject headings terms used were: ‘diverticular disease, diverticulosis, diverticulitis, genomics, genetics and epigenetics’. A review of grey literature identified environmental factors. Results Of 995 articles identified, 59 articles met the inclusion criteria. Age, obesity and smoking are strongly associated environmental risk factors. Intrinsic factors of the colonic wall are associated with the presence of diverticula. Genetic pathways of interest and environmental risk factors were identified. The COLQ, FAM155A, PHGR1, ARHGAP15, S100A10, and TNFSF15 genes are the strongest candidates for further research. Conclusion There is increasing evidence to support the role of genomics in the spectrum of diverticular disease. Genomic, epigenetic and omic research with demographic context will help improve the understanding and management of this complex disease.

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“…This was most notable in those with a first-degree family member affected by diverticulitis (HR 1.7; 95% c.i. 1.4 to 2.2) 30 .…”

Section: Epidemiologymentioning

confidence: 99%

“…However, studies investigating ancestry present conflicting data about the increased prevalence of DD in individuals with a positive family history. Some studies do show that individuals with a strong family history are more likely to have surgical management for DD 30 , 55 , 56 (see Table 1 for extrinsic factors related to DD).…”

Section: Epidemiologymentioning

confidence: 99%

Genetic, epigenetic and environmental factors in diverticular disease: systematic review

Humphrey,

Sibley,

Walker

et al. 2024

BJS Open

View full text Add to dashboard Cite

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Recurrence of severe diverticulitis is associated with age and birth decade

Leonard,

Horns,

Allen-Brady

et al. 2024

Journal of Gastrointestinal Surgery

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Diverticulitis Familiality: A Statewide Case-Control Study

Horns

Ramsay

Huang

et al. 2023

Journal of the American College of Surgeons

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Background: The etiology of diverticulitis is multifactorial and poorly understood. We estimated the familiality of diverticulitis using the Utah Population Database (UPDB), a statewide database linking medical records with genealogy data. Study Design: We identified patients with diverticulitis diagnosed between 1998-2018 and age- and sex-matched controls in the UPDB. Risk of diverticulitis in family members of cases and controls was calculated using multivariable Poisson models. We performed exploratory analyses to determine the association of familial diverticulitis with severity of disease and age of onset. Results: The study population included 9,563 diverticulitis cases (with 229,647 relatives) and 10,588 controls (with 265,693 relatives). Relatives of cases were more likely to develop diverticulitis (incidence rate ratio (IRR) 1.5, 95%CI 1.4,1.6) compared with relatives of controls. Further, there was an elevated risk of diverticulitis among first-degree (IRR 2.6, 95% CI 2.3,3.0), second-degree (IRR 1.5, 95%CI 1.3,1.6), and third-degree relatives of cases (IRR 1.3, 95%CI 1.2,1.4). Complicated diverticulitis was more common among relatives of cases compared with relatives of controls (IRR 1.6, 95%CI 1.4,1.8). Age at diverticulitis diagnosis was similar between groups (relatives of cases 0.2 years older than relatives of controls, 95%CI -0.5,0.9). Conclusion: Our results indicate that the first-, second-, and third-degree relatives of diverticulitis patients are at elevated risk of developing diverticulitis. This information may aid surgeons in counseling patients and family members about diverticulitis risk and can inform the development of future risk-stratification tools. Further work is needed to clarify the causal role and relative contribution of various genetic, lifestyle, and environmental factors in the development of diverticulitis.

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The Association Between Family History and Diverticulitis Recurrence: A Population-Based Study

Cited by 3 publications

References 39 publications

Genetic, epigenetic and environmental factors in diverticular disease: systematic review

Genetic, epigenetic and environmental factors in diverticular disease: systematic review

Recurrence of severe diverticulitis is associated with age and birth decade

Diverticulitis Familiality: A Statewide Case-Control Study

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