The Association Between Eye Color and Corneal Sensitivity Measured Using a Belmonte Esthesiometer

Henderson, L.; Bond, David Kyle; Simpson, Trefford

doi:10.1097/01.opx.0000171817.32551.05

Cited by 10 publications

(9 citation statements)

References 14 publications

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“…Studies have reported both qualitative and quantitative evidence of increased startle magnitude among high BI infants and children (Barker et al 2014), as well as higher BI scores among children with blue vs. brown eye color (Rosenberg & Kagan 1989). Blue-eyed adults have also been reported to have higher reactivity and lower detection thresholds in response to a range of diferent sensory stimuli (Hood et al 1976; Herbener et al 1989; Barrenas & Hellstrom, 1996; Henderson et al 2005; Acosta et al 2006). In the present sample, eye color was recorded for 261 subjects, blind to hypothesis.…”

Section: Resultsmentioning

confidence: 99%

Sensorimotor gating in healthy adults tested over a 15 year period

Swerdlow

Bhakta

Rana

et al. 2017

Biological Psychology

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Background Prepulse inhibition (PPI) of startle, an operational measure of sensorimotor gating, is used to study normal and pathological brain function. From 2001 - 2016, we screened healthy subjects (HS) to establish their suitability for tests of drug effects on PPI. Because of the size and systematic characterization of this sample across variables of relevance to PPI, we now report these screening results. Methods Acoustic startle and PPI were assessed in HS to identify those eligible for studies of drug effects on PPI from 2001-2016, yielding 457 “eligible” subjects. Results Data confirmed the consistency of PPI across this 15-year period, and supported the role of several variables previously reported to moderate either startle or PPI. Conclusions Startle and PPI are robust physiological measures that are predictably moderated by specific physiological variables in healthy adults. As such, these measures serve as robust markers of neurobiological processes in healthy and patient populations.

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Section: Resultsmentioning

confidence: 99%

Sensorimotor gating in healthy adults tested over a 15 year period

Swerdlow

Bhakta

Rana

et al. 2017

Biological Psychology

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“…Corneal sensitivity provides an important measure of corneal nerve function. Stimulation is conveyed via the trigeminal nerve via three different sensory receptors: mechanical (mechano‐nociceptors), chemical (polymodal nociceptors) and thermal (cold receptors) 28,31 . The mechanical receptors are myelinated fibres and constitute approximately 20 per cent of corneal sensory fibres.…”

Section: Corneal Innervation and Morphologymentioning

confidence: 99%

Assessing corneal nerve structure and function in diabetic neuropathy

Tavakoli

Petropoulos

Malik

2012

Clinical and Experimental Optometry

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The accurate detection and quantification of human diabetic peripheral neuropathy are important to define at-risk patients, anticipate deterioration and assess new therapies. Two emerging ophthalmic techniques, namely, corneal confocal microscopy and corneal aesthesiometry, demonstrate the ability to diagnose, quantify severity and assess therapeutic benefit in diabetic peripheral neuropathy. Corneal confocal microscopy allows quantification of corneal nerve morphology and non-contact corneal aesthesiometry assesses corneal sensitivity. The present review provides a detailed critique of the rationale, practical application in terms of the instruments used to capture images and the basis on which images are interpreted and analysed. We also critically evaluate how these two new non-invasive ophthalmic tests can be deployed to diagnose diabetic and other peripheral neuropathies.

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“…Millodot[ 7 ] and Roszkowska et al,[ 9 ] using the contact Cochet–Bonnet esthesiometer, did not find a significant difference in corneal sensitivity between men and women. Henderson et al[ 8 ] also found the same result using a non-contact corneal esthesiometer. On the other hand, Golebiowski et al[ 10 ] and Acosta et al[ 12 ] using non-contact corneal esthesiometry reported that corneal sensitivity in women is higher than men.…”

Section: Discussionmentioning

confidence: 59%

“…The issue of gender differences in corneal sensitivity has been much disputed in the field of neuro-ophthalmology. In a number of previous studies,[ 7 8 9 ] no difference was found between the genders; however, in Golebiowski's study,[ 10 ] men showed higher thresholds, i.e., less corneal sensitivity, than women. The aim of this study was to measure and compare corneal sensitivity between men and women.…”

Section: Introductionmentioning

confidence: 77%

Is corneal sensitivity sex dependent?

Khezri¹,

Mirzajani²,

Karimian³

et al. 2015

J Ophthalmic Vis Res

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Purpose:To determine whether corneal sensitivity is different between the two genders.Methods:Corneal sensitivity of 130 normal volunteers, including 77 women and 53 men aged 20-35 years, with no history of previous ocular surgery was measured using the Cochet-Bonnet esthesiometer. Measurements were done on five corneal regions: central, nasal, inferior, temporal and superior. The findings were compared between men and women using the non-parametric Mann-Whitney U test.Results:Mean age of male subjects was 28.0 years and that of female participants was 26.8 years (P = 0.063). There was a significant difference in corneal sensitivity between men and women in the superior (P = 0.013), temporal (P = 0.020) and inferior (P = 0.046) regions. There was no significant difference in corneal sensitivity in the central (P = 0.862) and nasal (P = 0.273) regions.Conclusion:Except for the central and nasal regions, corneal sensitivity is significantly higher in men as compared to women. The reason for this difference is not yet evident.

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The Association Between Eye Color and Corneal Sensitivity Measured Using a Belmonte Esthesiometer

Cited by 10 publications

References 14 publications

Sensorimotor gating in healthy adults tested over a 15 year period

Sensorimotor gating in healthy adults tested over a 15 year period

Assessing corneal nerve structure and function in diabetic neuropathy

Is corneal sensitivity sex dependent?

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