The association between embryo quality and perinatal outcome of singletons born after single embryo transfers: a pilot study

Abstract

Only internal funding was used. There is no conflict of interest in relation to the study.

Does IVF cleavage stage embryo quality affect pregnancy complications and neonatal outcomes in singleton gestations after double embryo transfers?

“…We hypothesize that poor embryo quality is associated with a high risk of miscarriage and pregnancy complications. In agreement with recent findings [20], our study demonstrated no relationship between pregnancy complications and embryo quality. We also did not observe better neonatal outcomes in singleton gestations resulting from good-quality embryos compared with poor-quality embryos.…”

“…A prior study suggested that trophectoderm grading of blastocysts is correlated with ongoing pregnancy and miscarriages [33]. In contrast, Oron et al reported that when pregnancy is achieved, there is a similar probability of having a live birth with a poor-quality embryo transfer [20]. The Oron et al study had a relatively small number of transfer cycles (1,193 cycles with good-quality embryos vs. 348 cycles with poor-quality embryos) and bias of embryo stage, both with cleavage and blastocyst embryos in their cohort.…”

“…Ebner et al [19] reported that bad quality embryo is associated with a high percentage of congenital malformations based on 164 pregnancies. A recent study demonstrated that miscarriage and ongoing pregnancy rate, congenital malformations, pregnancy complications, and neonatal outcomes of singletons were comparable between the good and poor quality embryo groups [20].…”

Embryo quality is the main factor affecting cumulative live birth rate after elective single embryo transfer in fresh stimulation cycles

“…The success in IVF treatment has been shown to have association with morphological parameters of the embryo [9]. On the other hand, a recentneonatal outcomes in SET cycles [10]. There are few studies on factors affecting cumulative outcomes in eSET cycles.…”

Perinatal outcomes of patients who achieved pregnancy with a morphologically poor embryo via assisted reproductive technology

“…A recent report compared the outcomes of singleton pregnancies that resulted from the transfer of a single fresh embryo that was of good quality with those resulting from the transfer of a single fresh poor-quality embryo in women 40 years old, after adjusting for confounding variables [8]. That report indicated that the poor quality of the embryo was not associated with an adverse obstetric or perinatal outcome.…”