The Association between Embryo Development and Chromosomal Results from PGT-A in Women of Advanced Age: A Prospective Cohort Study

Santamonkunrot, Pornchanit; Samutchinda, Sonsiri; Niransuk, Pornsri; Satirapod, Chonthicha; Sukprasert, Matchuporn

doi:10.3390/jcm13020626

Cited by 1 publication

(1 citation statement)

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“…While the primary goal of PGT-A is to improve live birth rates by selecting euploid embryos, consistent results across studies using PGT-A for all couples undergoing IVF-including women aged 35 to 40 yearshave not been reported. Based on data from various randomized trials, its broad applicability to all patient groups is still unclear [35,36].…”

Section: ) Blastocyst Biopsymentioning

confidence: 99%

Advanced strategies for single embryo selection in assisted human reproduction: A review of clinical practice and research methods

Bashiri,

Afzali,

Koruji

et al. 2024

Clin Exp Reprod Med

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Among the primary objectives of contemporary assisted reproductive technology research are achieving the births of healthy singletons and improving overall fertility outcomes. Substantial advances have been made in refining the selection of single embryos for transfer, with the aim of maximizing the likelihood of successful implantation. The principal criterion for this selection is embryo morphology. Morphological evaluation systems are based on traditional parameters, including cell count and fragmentation, pronuclear morphology, cleavage rate, blastocyst formation, and various sequential embryonic assessments. To reduce the incidence of multiple pregnancies and to identify the single embryo with the highest potential for growth, invasive techniques such as preimplantation genetic screening are employed in in vitro fertilization clinics. However, new approaches have been suggested for clinical application that do not harm the embryo and that provide consistent, accurate results. Noninvasive technologies, such as time-lapse imaging and omics, leverage morphokinetic parameters and the byproducts of embryo metabolism, respectively, to identify noninvasive prognostic markers for competent single embryo selection. While these technologies have garnered considerable interest in the research community, they are not incorporated into routine clinical practice and still have substantial room for improvement. Currently, the most promising strategies involve integrating multiple methodologies, which together are anticipated to increase the likelihood of successful pregnancy.

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Section: ) Blastocyst Biopsymentioning

confidence: 99%