The association between different night shiftwork factors and breast cancer: a case–control study

Fritschi, Lin; Erren, Thomas C.; Glass, Deborah Catherine; Girschik, Jennifer; Thomson, Allyson; Saunders, Christobel; Boyle, Terry; El‐Zaemey, Sonia; Rogers, Pierra; Peters, Susan; Slevin, Terry; D'Orsogna, A.; Vocht, Frank de; Vermeulen, Roel; Heyworth, Jane

doi:10.1038/bjc.2013.544

Cited by 93 publications

(93 citation statements)

References 40 publications

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“…We could not corroborate a short-term effect of night shift work on the risk of breast cancer as suggested by experimental data (10,16). This finding is consistent with that of Fritschi et al (20) and Pesch et al (18) who observed no elevated risk among women working night shifts within the recent ten years [odds ratios (OR) 1.02, 95% CI 0.73-1.43 and 1.04, 95% CI 0.31-3.53, respectively]. However, our findings are not consistent with the findings of Davis et al who observed a slightly elevated risk during the recent ten years of night shift work (OR 1.6, 95% CI 1.0-2.5) (19).…”

Section: Discussionsupporting

confidence: 48%

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Short-term effects of night shift work on breast cancer risk: a cohort study of payroll data

Vistisen¹,

Garde²,

Frydenberg³

et al. 2016

Scand J Work Environ Health

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Section: Discussionsupporting

confidence: 48%

“…Of the several epidemiologic studies conducted, only three studies have examined possible short-term risk of recent night shift work (18)(19)(20). Davis et al observed an increased risk of breast cancer among women who ever worked the graveyard shift during the last ten years (19).…”

mentioning

confidence: 99%

Short-term effects of night shift work on breast cancer risk: a cohort study of payroll data

Vistisen¹,

Garde²,

Frydenberg³

et al. 2016

Scand J Work Environ Health

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“…However, some other studies failed to establish a clear association [161]. This case-control study evaluated the association between variant night shift factor and breast cancer incidences in Western Australia using a self-administered questionnaire and telephone interview to obtain details about demography, lifestyle, occupational history, and shift work factors, including ALAN, phase shift, and sleep duration [161]. In this study, night shift has been found to be associated with a small but statistically significant increase risk for breast cancer, but the association with other shift work factors, such as duration of exposure to ALAN and sleep disturbance, showed inconsistent results.…”

Section: Circadian Disruption and Breast Cancermentioning

confidence: 99%

“…Most of the epidemiological and experimental data provide a well-established association between circadian disruption by shift work, ALAN, and breast cancer risk. However, some other studies failed to establish a clear association [161]. This case-control study evaluated the association between variant night shift factor and breast cancer incidences in Western Australia using a self-administered questionnaire and telephone interview to obtain details about demography, lifestyle, occupational history, and shift work factors, including ALAN, phase shift, and sleep duration [161].…”

Section: Circadian Disruption and Breast Cancermentioning

confidence: 99%

Artificial light-at-night – a novel lifestyle risk factor for metabolic disorder and cancer morbidity

Zubidat

Haim

2017

Journal of Basic and Clinical Physiology and Pharmacology

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Both obesity and breast cancer are already recognized worldwide as the most common syndromes in our modern society. Currently, there is accumulating evidence from epidemiological and experimental studies suggesting that these syndromes are closely associated with circadian disruption. It has been suggested that melatonin (MLT) and the circadian clock genes both play an important role in the development of these syndromes. However, we still poorly understand the molecular mechanism underlying the association between circadian disruption and the modern health syndromes. One promising candidate is epigenetic modifications of various genes, including clock genes, circadian-related genes, oncogenes, and metabolic genes. DNA methylation is the most prominent epigenetic signaling tool for gene expression regulation induced by environmental exposures, such as artificial light-at-night (ALAN). In this review, we first provide an overview on the molecular feedback loops that generate the circadian regulation and how circadian disruption by ALAN can impose adverse impacts on public health, particularly metabolic disorders and breast cancer development. We then focus on the relation between ALAN-induced circadian disruption and both global DNA methylation and specific loci methylation in relation to obesity and breast cancer morbidities. DNA hypo-methylation and DNA hyper-methylation, are suggested as the most studied epigenetic tools for the activation and silencing of genes that regulate metabolic and monostatic responses. Finally, we discuss the potential clinical and therapeutic roles of MLT suppression and DNA methylation patterns as novel biomarkers for the early detection of metabolic disorders and breast cancer development.

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“…Studies on breast cancer that have accounted for sun exposure in their analyses reported only marginal changes in their night work risk estimates. 4,5 The role of sunlight exposure and vitamin D has been long debated and the evidence from observational studies, on levels of serum 25-hydroxyvitamin D and incidence of prostate cancer is inconclusive.…”

mentioning

confidence: 99%

Authors' response to Letter to the Editor

Kogevinas

Papantoniou

2015

Int. J. Cancer

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We thank W.B. Grant for his comments on our paper on night shift work and prostate cancer risk and his suggestion that lack of vitamin D may be one of the causes for higher cancer risk in night workers.1 The association between night shift work and cancer including prostate cancer is complex. Several pathways are involved, including circadian disruption, melatonin suppression, sleep deprivation, circadian gene deregulation and lifestyles changes.2 It has been suggested that inadequate vitamin D levels related to reduced time spent outdoors among night workers may be one of the multiple underlying mechanisms and this is certainly a potential pathway linking night work and cancer that should be further examined.Our study is the first study to consider sun exposure as a possible confounding factor of the night work-prostate cancer association. 3 We assessed present and past sun exposure summer habits through a questionnaire, as proxies for vitamin D levels at least for the brightest months of the year, although we agree that it would have been preferable if more details (e.g., unbathing, protection cream) were available. All models were adjusted for past sun exposure that was not a major confounder of the night shift work-prostate cancer association. Studies on breast cancer that have accounted for sun exposure in their analyses reported only marginal changes in their night work risk estimates. 4,5 The role of sunlight exposure and vitamin D has been long debated and the evidence from observational studies, on levels of serum 25-hydroxyvitamin D and incidence of prostate cancer is inconclusive.6,7 Furthermore, although counterintuitive, it is not clear that night shift or rotating night shift workers spend less time or receive less sunlight exposure compared to day workers. In the present study, we did not find differences in sunlight exposure between day and night workers.3 Similarly in a recent nested case-control study, night shift workers reported more frequent sun exposure than those with day work, that often spend most of the daytime hours working indoors.5 More data are needed on sun exposure and vitamin D levels among current and past night workers, in order to confirm if this biologically plausible hypothesis can explain part of the increased risk for prostate cancer observed among night shift workers.

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The association between different night shiftwork factors and breast cancer: a case–control study

Cited by 93 publications

References 40 publications

Short-term effects of night shift work on breast cancer risk: a cohort study of payroll data

Short-term effects of night shift work on breast cancer risk: a cohort study of payroll data

Artificial light-at-night – a novel lifestyle risk factor for metabolic disorder and cancer morbidity

Authors' response to Letter to the Editor

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