The association between diet and chronic obstructive pulmonary disease in subjects selected from general practice

Watson, Louise; Margetts, Barrie; Howarth, Peter H.; Dorward, Martina; Thompson, Rachel; Little, Paul

doi:10.1183/09031936.02.00256402

Cited by 51 publications

(40 citation statements)

References 23 publications

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“…The main finding of the present study was that COPD patients who followed a diet with a high intake of fruit and vegetables showed an annual increase in percentage predicted FEV1, whereas patients who were on a standard diet exhibited a [2,6,15,25], despite the differences in design and study population between the present and former studies.…”

Section: Discussioncontrasting

confidence: 35%

Impact of dietary shift to higher-antioxidant foods in COPD: a randomised trial

Keranis¹,

Makris²,

Rodopoulou³

et al. 2010

European Respiratory Journal

100

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Chronic obstructive pulmonary disease (COPD) is characterised by increased oxidative stress. Dietary factors, such as ample consumption of foods rich in antioxidants, such as fruit and vegetables, might have beneficial effects in COPD patients.The association between dietary shift to foods rich in antioxidants and lung function in COPD was investigated in a 3-yr prospective study. A total of 120 COPD patients were randomised to follow either a diet based on increased consumption of fresh fruit and vegetables (intervention group (IG)) or a free diet (control group (CG)).The mean consumption of foods containing antioxidants was higher in the IG than in the CG throughout the study period (p,0.05). The relationship between consumption of foods rich in antioxidants and percentage predicted forced expiratory volume in 1 s was assessed using a general linear model for repeated measures; the two groups overall were different in time (p50.03), with the IG showing a better outcome. In investigating the effect of several confounders (sex, age, smoking status, comorbid conditions and exacerbation) of group response over time, nonsignificant interactions were found between confounders, group and time.These findings suggest that a dietary shift to higher-antioxidant food intake may be associated with improvement in lung function, and, in this respect, dietary interventions might be considered in COPD management.

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Section: Discussioncontrasting

confidence: 35%

Impact of dietary shift to higher-antioxidant foods in COPD: a randomised trial

Keranis¹,

Makris²,

Rodopoulou³

et al. 2010

European Respiratory Journal

100

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show abstract

“…It has also been proposed that a diet rich in omega-3 fatty acids may inhibit arachidonic acid production, thereby protecting against bronchoconstriction. While it has been demonstrated that a diet rich in fruit and vegetables is associated with a reduced risk of COPD [110], the effect that modification of diet has on the prevalence of COPD is yet to be determined.…”

Section: Dietmentioning

confidence: 99%

Epidemiology and costs of chronic obstructive pulmonary disease

Mannino

Soriano

et al. 2006

European Respiratory Journal

620

395

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“…Higher levels of dietary or plasma antioxidants have been associated with better pulmonary function, as demonstrated by a higher level and lower rate of decline of the forced expiratory volume in 1 s (FEV 1 ), and a decreased risk of chronic obstructive pulmonary disease (COPD) [35,36]. Major nonenzymatic antioxidants present at respiratory tract surfaces include ascorbate, urate, α-tocopherol, reduced glutathione (GSH), mucins, and albumin.…”

Section: Oxidative Stress In the Lungmentioning

confidence: 99%

Antioxidants in cystic fibrosis☆Conclusions from the CF Antioxidant Workshop, Bethesda, Maryland, November 11-12, 2003

Cantin

White

Cross

et al. 2007

Free Radical Biology and Medicine

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Although great strides are being made in the care of individuals with cystic fibrosis (CF), this condition remains the most common fatal hereditary disease in North America. Numerous links exist between progression of CF lung disease and oxidative stress. The defect in CF is the loss of function of the transmembrane conductance regulator (CFTR) protein; recent evidence that CFTR expression and function are modulated by oxidative stress suggests that the loss may result in a poor adaptive response to oxidants. Pancreatic insufficiency in CF also increases susceptibility to deficiencies in lipophilic antioxidants. Finally the airway infection and inflammatory processes in the CF lung are potential sources of oxidants that can affect normal airway physiology and contribute to the mechanisms causing characteristic changes associated with bronchiectasis and loss of lung function. These multiple abnormalities in the oxidant/antioxidant balance raise several possibilities for therapeutic interventions that must be carefully assessed. IntroductionCystic fibrosis (CF) is the most common fatal disease caused by a single gene defect in Europe and North America [1,2]. The defective gene was identified in 1989 [3][4][5] and shown to encode the cystic fibrosis trans-membrane conductance regulator protein (CFTR). CFTR is a cyclic AMP-regulated anion channel with greatest selectivity for chloride, and bicarbonate [6][7][8]. Furthermore, CFTR regulates sodium transport across epithelial membranes through interactions with the epithelial sodium channel ENaC [9], and facilitates the trans-membrane export of the small organic anionic peptide glutathione [10]. The expression of CFTR is located in the apical membrane of epithelial cells that line mucous membranes and submucosal glands ☆ A list of participants may be found in the Acknowledgments.

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The association between diet and chronic obstructive pulmonary disease in subjects selected from general practice

Cited by 51 publications

References 23 publications

Impact of dietary shift to higher-antioxidant foods in COPD: a randomised trial

Impact of dietary shift to higher-antioxidant foods in COPD: a randomised trial

Epidemiology and costs of chronic obstructive pulmonary disease

Antioxidants in cystic fibrosis☆Conclusions from the CF Antioxidant Workshop, Bethesda, Maryland, November 11-12, 2003

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