The Association Between Diabetes Mellitus and the Risk of Latent Tuberculosis Infection: A Systematic Review and Meta-Analysis

Li, Qiao; Yan, Wenxin; Bo, Ershu; Liu, Jue; M, Liu

doi:10.2139/ssrn.3829644

Cited by 1 publication

(1 citation statement)

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“…Our methods have been described in detail in our published protocol ( 26 ) [PROSPERO (Prospective register of systematic reviews) registration, CRD42021244647]. We searched for eligible studies published by 31 December 2021, from four databases including PubMed, Embase, Web of Science and Cochrane Library by the following search terms: (“tuberculin test” or “interferon-gamma release tests” or “latent tuberculosis” or “tuberculin skin test” or “interferon gamma release assay”) AND (“diabetes mellitus” or “diabetes”) OR “latent tuberculosis” (full search strategies were shown in Supplementary Table 1 ).…”

Section: Methodsmentioning

confidence: 99%

The Association Between Diabetes Mellitus and the Risk of Latent Tuberculosis Infection: A Systematic Review and Meta-Analysis

Yan

et al. 2022

Front. Med.

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BackgroundThe estimated global latent tuberculosis infection (LTBI) burden indicates a large reservoir of population at risk of developing active tuberculosis (TB). Previous studies suggested diabetes mellitus (DM) might associate with LTBI, though still controversial. We aimed to systematically assess the association between DM and LTBI.MethodsWe searched PubMed, Embase, Cochrane Library and Web of Science. Observational studies reporting the number of LTBI and non-LTBI individuals with and without DM were included. Random-effects or fixed-effects models were used to estimate the pooled effect by risk ratios (RRs) and odds ratios (ORs) and its 95% confidence interval (CI), using the original number of participants involved.Results20 studies involving 4,055,082 participants were included. The pooled effect showed a significant association between DM and LTBI (for cohort studies, RR = 1.62, 95% CI: 1.02–2.56; for cross-sectional studies, OR = 1.55, 95% CI: 1.30–1.84). The pooled OR was high in studies with healthcare workers (5.27, 95% CI: 1.52–8.20), refugees (2.88, 95% CI: 1.93–4.29), sample size of 1,000–5,000 (1.99, 95% CI: 1.49–2.66), and male participants accounted for less than 40% (2.28, 95% CI: 1.28–4.06). Prediabetes also associated with LTBI (OR = 1.36, 95% CI: 1.01–1.84).ConclusionThe risk of LTBI was found to be a 60% increase in DM patients, compared with non-DM patients. LTBI screening among DM patients could be of vital importance. More studies are needed to explore appropriate strategies for targeted LTBI screening among DM patients.

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Section: Methodsmentioning

confidence: 99%