The Association Between Depressive Symptoms and Age in Cancer Patients: A Multicenter Cross-Sectional Study

Wada, Saho; Shimizu, Ken; Inoguchi, Hironobu; Shimoda, Haruki; Yoshiuchi, Kazuhiro; Akechi, Tatsuo; Uchida, Megumi; Ogawa, Asao; Fujisawa, Daisuke; Inoue, Shinichirou; Uchitomi, Yosuke; Matsushima, Eisuke

doi:10.1016/j.jpainsymman.2015.07.011

Cited by 18 publications

(11 citation statements)

References 54 publications

(42 reference statements)

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“…These results are consistent with previous research demonstrating that younger individuals experience more distress throughout the cancer experience (Wada et al, 2015) and that smoking places individuals at risk for compromised health (Duffy et al, 2007; Llewellyn, McGurk, & Weinman, 2005). Results are also in line with research showing that cancer-related symptoms play a major role in well-being; one study observed that HNC patient but not caregiver distress was worse when patients had poorer functioning (Verdonck-de Leeuw et al, 2007).…”

Section: Discussionsupporting

confidence: 92%

Physical and emotional well-being and support in newly diagnosed head and neck cancer patient–caregiver dyads

Sterba

Zapka

Armeson

et al. 2017

Journal of Psychosocial Oncology

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The purpose of this study was to examine the physical and emotional well-being and social support in newly diagnosed head and neck cancer (HNC) patients and caregivers and identify sociodemographic, clinical, and behavioral risk factors associated with compromised well-being in patients and caregivers. Newly diagnosed HNC patients and their primary caregivers (N = 72 dyads) completed questionnaires before treatment assessing physical and mental well-being, depression, cancer worry, and open-ended support questions. Patients reported worse physical well-being than caregivers (p < 0.05) but similar levels of mental well-being. Caregivers reported providing emotional and instrumental support most frequently with an emphasis on nutrition and assistance with speech, appearance, and addictions. Both patients and their caregivers reported suboptimal mental well-being and depression. Smoking was associated with compromised well-being in patients, caregivers, and dyads. Compromised well-being in patients and their caregivers was more likely when patients were younger, had worse symptoms, and smoked/consumed alcohol (p < 0.05). While patients face more physical strain than caregivers, both equally confront emotional challenges. Results highlight risk factors for compromised well-being in both patients and their caregivers that should be assessed at diagnosis to guide identification of needed dyadic-focused supportive care resources.

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Section: Discussionsupporting

confidence: 92%

Physical and emotional well-being and support in newly diagnosed head and neck cancer patient–caregiver dyads

Sterba

Zapka

Armeson

et al. 2017

Journal of Psychosocial Oncology

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“…While age, gender, and years of education are non-modifiable demographic characteristics, they are easily identifiable risk factors. Consistent with prior reports,[8,40,41] younger age was associated with higher fatigue severity. Potential explanations for this association may include: older patients being given lower doses of CTX;[42] age-related changes that modify inflammatory responses;[43] or a “response shift” in the symptom perceptions of older patients.…”

Section: Discussionsupporting

confidence: 92%

Distinct evening fatigue profiles in oncology outpatients receiving chemotherapy

Wright

Cooper

Conley

et al. 2017

Fatigue: Biomedicine, Health & Behavior

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Background Fatigue is the most common and debilitating symptom experienced by oncology patients during chemotherapy (CTX). Fatigue severity demonstrates a large amount of inter-individual and diurnal variability. Purpose Study purposes were to evaluate for subgroups of patients with distinct evening fatigue profiles and evaluate how these subgroups differed on demographic, clinical, and symptom characteristics. Methods Outpatients with breast, gastrointestinal, gynecological, or lung cancer (n=1332) completed questionnaires six times over two cycles of CTX. Lee Fatigue Scale (LFS) evaluated evening fatigue severity. Latent profile analysis was used to identify distinct evening fatigue profiles. Results Four distinct evening fatigue classes (i.e., Low (14.0%), Moderate (17.2%), High (36.0%), Very High (32.8%)) were identified. Compared to the Low class, patients in the Very High evening fatigue class were: younger, female, had childcare responsibilities, had more years of education, had a lower functional status, had a higher comorbidity burden, and were diagnosed with breast cancer. Patients in the Very High class reported higher levels of depressive symptoms, sleep disturbance, and evening fatigue at enrollment. Conclusions Findings provide new insights into modifiable risk factors for higher levels of evening fatigue. Clinicians can use this information to identify higher risk patients and plan appropriate interventions.

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“…The timing of screening of psychological distress should be taken into account, as one year from the cancer diagnosis seems to be a time period, when patients cope better with distress, but shortly after treatment ends, distress level has been suggested to rise . As young cancer patients are suggested to be especially vulnerable to depressive symptoms, they should be monitored carefully . We did not find any clear difference in the magnitude of the risk for AD purchases within one year from cancer diagnosis compared to the time after one year from diagnosis.…”

Section: Discussionmentioning

confidence: 77%

Purchases of antidepressants after cancer at a young age in Finland

Ahomäki

Kero

Koivisto

et al. 2018

Intl Journal of Cancer

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According to previous studies, childhood cancer survivors have an elevated risk for late mental health effects. However, only few studies exist on young adulthood (YA) cancer survivors' mental health outcomes. In our study, we examined first time antidepressant (AD) medication purchases of childhood and YA cancer patients compared to siblings. The first time AD medication purchases of 7,093 cancer patients aged 0-34 years at diagnosis and a sibling cohort (N = 26,882) were retrieved from the Social Insurance Institution of Finland (Kela) since 1.1.1993. Cancer patients diagnosed between 1.1.1994 and 31.12.2004 were identified from the Finnish Cancer Registry and sibling controls via the Population Registry Centre. Statistical analyses were performed via the Cox regression model, and the hazard ratios (HR) were adjusted for age and gender. Increased hazard ratios for AD purchases were found in the younger (0-19 years at cancer diagnosis) [HR 5.2, 95%CI (3.7-7.2)] and older (age 20-34 years at cancer diagnosis) [HR 4.5, 95%CI (3.9-5.2)] cancer patient groups compared to siblings. The gender effect was similar in patients and controls, showing that females have higher risk for AD purchases than males. Males in the younger patient group had highest HR (5.6) for AD purchases compared to siblings. Patients with sarcoma or CNS tumor in the younger age group and leukemia or CNS malignancy in the older age group had the highest risk for AD medication purchases. The frequency and risk for AD purchases has been increasing during recent decades in both cancer patient age groups compared to siblings. Thus, cancer patients' psychological support should be properly assessed already after primary treatment. Certain diagnostic groups as well as female patients may require more psychological support than others.

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The Association Between Depressive Symptoms and Age in Cancer Patients: A Multicenter Cross-Sectional Study

Cited by 18 publications

References 54 publications

Physical and emotional well-being and support in newly diagnosed head and neck cancer patient–caregiver dyads

Physical and emotional well-being and support in newly diagnosed head and neck cancer patient–caregiver dyads

Distinct evening fatigue profiles in oncology outpatients receiving chemotherapy

Purchases of antidepressants after cancer at a young age in Finland

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