The association between depression and metabolic syndrome and its components: a bidirectional two-sample Mendelian randomization study

Zhang, Min; Chen, Jing; Yin, Zhiqun; Wang, Lanbing; Peng, Lihua

doi:10.1038/s41398-021-01759-z

Cited by 75 publications

(41 citation statements)

References 71 publications

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“…A similar IVW analysis suggest the direction of influence is from MDD to MetS (40 genetic instruments, b = 0.23, SE = 0.06, p = 1.3E-04) rather than from MetS to MDD (108 genetic instruments, b = 0.015, SE = 0.011, p = 0.165). This comports with previous reports of the effect of depression phenotypes on metabolic dysregulation [ 17 , 23 ].…”

Section: Resultssupporting

confidence: 90%

“…Some previous studies reported significant genetic correlation between MetS and depression phenotypes [ 17 , 23 ]. To compare estimates of genetic associations of MetS and PTSD with genetic associations of MetS and MDD, we computed genetic correlation estimates with MDD using the same summary statistics of metabolic traits.…”

Section: Resultsmentioning

confidence: 99%

“…Various aspects of the association between MDD and MetS have been extensively studied, showing a clear epidemiological co-occurrence as well as significant genetic overlap [ 15 , 16 ]. Some Mendelian randomization studies also suggested the direction of influence is from MDD to MetS [ 17 ]. However, it is not clear whether the genetic relationship between PTSD and MetS resembles that of between MDD and MetS.…”

Section: Introductionmentioning

confidence: 99%

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The Genetic Basis for the Increased Prevalence of Metabolic Syndrome among Post-Traumatic Stress Disorder Patients

Misganaw

Yang

Gautam

et al. 2022

IJMS

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Post-traumatic stress disorder (PTSD) is a highly debilitating psychiatric disorder that can be triggered by exposure to extreme trauma. Even if PTSD is primarily a psychiatric condition, it is also characterized by adverse somatic comorbidities. One illness commonly co-occurring with PTSD is Metabolic syndrome (MetS), which is defined by a set of health risk/resilience factors including obesity, elevated blood pressure, lower high-density lipoprotein cholesterol, higher low-density lipoprotein cholesterol, higher triglycerides, higher fasting blood glucose and insulin resistance. Here, phenotypic association between PTSD and components of MetS are tested on a military veteran cohort comprising chronic PTSD presentation (n = 310, 47% cases, 83% male). Consistent with previous observations, we found significant phenotypic correlation between the various components of MetS and PTSD severity scores. To examine if this observed symptom correlations stem from a shared genetic background, we conducted genetic correlation analysis using summary statistics data from large-scale genetic studies. Our results show robust positive genetic correlation between PTSD and MetS (rg[SE] = 0.33 [0.056], p = 4.74E-09), and obesity-related components of MetS (rg = 0.25, SE = 0.05, p = 6.4E-08). Prioritizing genomic regions with larger local genetic correlation implicate three significant loci. Overall, these findings show significant genetic overlap between PTSD and MetS, which may in part account for the markedly increased occurrence of MetS among PTSD patients.

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Section: Resultssupporting

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Genetic Basis for the Increased Prevalence of Metabolic Syndrome among Post-Traumatic Stress Disorder Patients

Misganaw

Yang

Gautam

et al. 2022

IJMS

View full text Add to dashboard Cite

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“…PAHs, NO 2 , and CO are related to biological toxicity (68-70). Similarly, higher levels of triglycerides and free fatty acids were observed among those living with depression, and it was reported that higher glucose concentrations of the pregenual anterior cingulate were associated with major depressive disorder (71)(72)(73). In a study from China, hyperlipidemia and hyperglycemia were related to cognitive impairment (53).…”

Section: Discussionmentioning

confidence: 92%

Association between the domestic use of solid cooking fuel and increased prevalence of depression and cognitive impairment in a big developing country: A large-scale population-based study

Jin

Zhou

Deng

et al. 2022

Front. Public Health

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BackgroundPrevious studies have suggested that air pollution affects physiological and psychological health. Using solid fuel at home is a significant source of indoor air pollution. The associations between solid fuel use and depressive symptoms and cognitive health were unclear among older adults from low- and middle-income countries (LMICs).MethodsTo evaluate the association of solid fuel use with depressive symptoms and cognitive health among older adults, we obtained data from the Longitudinal Aging Study in India (LASI) and excluded subjects younger than 60 years and without critical data (solid fuel use, depressive symptoms, and cognitive health). The 10-item Center for Epidemiologic Studies Depression Scale (CES-D-10) was used to assess depressive symptoms, with more than ten indicative of depression. Cognitive health was assessed using measures from the Health and Retirement Study (HRS), and subjects with the lowest 10th percentile were considered to have cognitive impairment. The participants' responses defined solid fuel use. Multivariable logistic regression, linear regression, subgroup analysis, and interaction tests were performed to appraise the relationship between solid fuel use and depression and cognitive impairment.ResultsA total of 29,789 participants over 60 years old were involved in this study. Almost half of the participants (47.5%) reported using solid fuel for home cooking. Compared with clean fuel use, solid fuel use was related to an increased prevalence of depression [odds ratio (OR) 1.09, 95% CI 1.03–1.16] and higher CES-D-10 scores (β 0.23, 95% CI 0.12–0.35) after fully adjusted covariables. Using solid fuel was also related to a higher risk of cognitive impairment (OR 1.21, 95% CI 1.11–1.32) and a lower cognitive score (β −0.63, 95% CI −0.79 to −0.47) compared with those who used clean fuel. In the subgroup analysis, the prevalence of depression increased in females and non-smokers. The association of solid fuel use with depression and cognitive impairment exists in subgroups of BMI, economic status, caste, living area, education, and drinking.ConclusionsThe use of solid fuel at home was associated with an increased prevalence of depression and cognitive impairment among older adults in India.

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“…Research has found that patients with psychiatric disorders are known to have higher morbidity and mortality compared to the overall population [ 96 ]. This is likely due to the metabolic syndrome that these patients experience, predisposing them to cardiovascular diseases, type 2 diabetes, hypertension, dyslipidemia, hyperglycemia, and obesity [ 97 ]. Various aspects impact this high comorbidity, including genetic factors.…”

Section: Gene Variants Predicting Predisposition To Obesity and Metab...mentioning

confidence: 99%

Pharmacogenomics in Psychiatry Practice: The Value and the Challenges

Alchakee

Ahmed

Eldohaji

et al. 2022

IJMS

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The activity of cytochrome P450 enzymes is influenced by genetic and nongenetic factors; hence, the metabolism of exogenous psychotropic medications and potentially some endogenous neuropeptides is variably affected among different ethnic groups of psychiatric patients. The aim of this review is to highlight the most common cytochrome P450 isoenzymes associated with the metabolism of psychotropic medications (antidepressants, antipsychotics, and mood stabilizers), their variations among different populations, their impact on endogenous neurotransmitters (dopamine and serotonin), and the effect of nongenetic factors, particularly smoking, age, and pregnancy, on their metabolic activity. Furthermore, the adverse effects of psychiatric medications may be associated with certain human leukocytic antigen (HLA) genotypes. We also highlight the gene variants that may potentially increase susceptibility to obesity and metabolic syndrome, as the adverse effects of some psychiatry medications. Collectively, the literature revealed that variation of CYP450 activity is mostly investigated in relation to genetic polymorphism, and is directly correlated with individualized clinical outcomes; whereas adverse effects are associated with HLA variants, projecting the value of pharmacogenetics implementation in psychiatry clinics. Only a few previous studies have discussed the impact of such genetic variations on the metabolism of endogenous neuropeptides. In this review, we also report on the prevalence of key variants in different ethnicities, by demonstrating publicly available data from the 1000 Genomes Project and others. Finally, we highlight the future direction of further investigations to enhance the predictability of the individual gene variants to achieve precision therapies for psychiatric patients.

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The association between depression and metabolic syndrome and its components: a bidirectional two-sample Mendelian randomization study

Cited by 75 publications

References 71 publications

The Genetic Basis for the Increased Prevalence of Metabolic Syndrome among Post-Traumatic Stress Disorder Patients

The Genetic Basis for the Increased Prevalence of Metabolic Syndrome among Post-Traumatic Stress Disorder Patients

Association between the domestic use of solid cooking fuel and increased prevalence of depression and cognitive impairment in a big developing country: A large-scale population-based study

Pharmacogenomics in Psychiatry Practice: The Value and the Challenges

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