The association between coronary slow flow and platelet distribution width among patients with stable angina pectoris

Abstract

IntroductionCoronary slow flow (CSF) is an angiographic phenomenon characterised by the delay of distal vessel opacification in the absence of significant stenosis of the epicardial coronary arteries. Some of the factors playing a role in CSF pathophysiology are increased thrombogenic activity and inflammation.AimTo examine the relationship between platelet distribution width (PDW) and CSF.Material and methodsTaking into consideration the exclusion criteria, 136 patients with CSF and 152 patients with normal coronary angiographies (control group) were included in the study. The association between thrombolysis infarction frame count (TFC) in myocardial and laboratory and other clinical parameters were evaluated.ResultsThe stated parameters were significantly higher in the group with CSF than in the normal coronary angiography group (control group). The PDW (16.6 ±0.7 vs. 16.4 ±0.6, p = 0.002), neutrophil lymphocyte ratio (NLR) (3.1 ±3.4 vs. 2.4 ±1.1, p = 0.027), haemoglobin (Hb) (14.1 ±1.3 vs. 14.7 ±1.1, p < 0.001), and red cell distribution width (RDW) (13.6 ±0.7 vs. 14.1 ±2.8, p = 0.026) were significantly higher in the CSF group than in the control group. Moreover, our study showed that PDW > 16.15 and Hb > 1 3.75 were predictors of the presence of CSF with sensitivities of 83% and 73% and specificities of 40% and 42%, respectively.ConclusionsThis study has demonstrated that compared to normal coronary flow, PDW, Hb, NLR, and RDW are significantly higher in CSF patients. We believe that further studies are needed to clarify the role of PDW and Hb in patients with CSF.

Red blood cell distribution width and myocardial scar burden in coronary artery disease

“…In keeping with this, Cecchi et al demonstrated an association between blood viscosity and infarct size in patients with ST-segment elevation MI undergoing primary percutaneous coronary intervention 20. Furthermore, elevated RDW was shown to be an independent predictor of impaired coronary collateral circulation in patients with non-ST elevation MI21 as well as slow coronary flow 22. Microvascular blood flow resistance secondary to impaired red cell deformability could be a common underlying mechanism.…”

Can blood parameters be used to assess the recovery time of Bell's palsy patients? A retrospective case-controlled study

“…[27] In recent studies, NLR in cardiovascular diseases has been extensively studied and appears to be a significant marker of inf lammation. [9,10] Based on microcirculatory theory, the NLR ratio is expected to also be high in Bell's palsy and only a few studies have taken place pertain ring to this issue. [11,28] In our study, NLR were studied in Bell's palsy patients, however in contrast to other studies it was not elevated.…”

“…[5][6][7][8][9][10] Neutrophil-to-lymphocyte ratio (NLR) has been defined as a novel potential marker to determine inf lammation. Mean platelet volume (MPV), plateletcrit (PCT), platelet distribution width (PDW) is shown as a potential marker of thrombosis and inf lammation.…”

“…Mean platelet volume (MPV), plateletcrit (PCT), platelet distribution width (PDW) is shown as a potential marker of thrombosis and inf lammation. [7][8][9][10][11] The aim of this study is to investigate whether NLR, MPV, platelet (PLT), PCT, PDW values can be used for the etiopathogenesis of Bell's palsy and the evaluation of recovery time.…”

Association between platelet distribution width and poor outcome of acute ischemic stroke after intravenous thrombolysis

“… 5 , 6 Several investigators found that both mean platelet volume (MPV) and platelet distribution width (PDW) were indicators of platelet activation. 7 – 9 The PDW represents the heterogeneity of platelet size, 4 , 5 with an elevated PDW indicating a patient still having activation of platelets. 4 , 5 , 7 , 10 Furthermore, PDW is a more direct marker to represent platelet reactivity than MPV.…”