The Association Between Coffee Consumption and Nonalcoholic Fatty Liver Disease in the South Korean General Population

Tan, Li-Juan; Jung, Hyein; Kim, Seong-Ah; Shin, Sangah

doi:10.1002/mnfr.202100356

Cited by 3 publications

(4 citation statements)

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“…Numerous meta-analyses have consistently reported the beneficial effects of coffee consumption on human health. These benefits include a reduction of oxidative damage (Tan et al 2021;Zheng et al 2022), an increase in telomere length (Cardin et al 2013), and activation proteins involved in cell protection (Wahl et al 2017;Kolb et al 2020;Karabegović et al 2021). Moreover, coffee consumption has been associated with a decrease in inflam-matory responses (Jones et al 2010;Aleksandrova et al 2015;Kolb et al 2020;Tan et al 2021;Zheng et al 2022), and collagen synthesis (Cardin et al 2013;Ebadi et al 2021).…”

Section: Discussionmentioning

confidence: 99%

“…These benefits include a reduction of oxidative damage (Tan et al 2021;Zheng et al 2022), an increase in telomere length (Cardin et al 2013), and activation proteins involved in cell protection (Wahl et al 2017;Kolb et al 2020;Karabegović et al 2021). Moreover, coffee consumption has been associated with a decrease in inflam-matory responses (Jones et al 2010;Aleksandrova et al 2015;Kolb et al 2020;Tan et al 2021;Zheng et al 2022), and collagen synthesis (Cardin et al 2013;Ebadi et al 2021). The anti-inflammatory and antioxidant properties of coffee consumption may also help reduce the risk of NAFLD, hepatic fibrosis (Ebadi et al 2021;Tan et al 2021), www.journal-dtt.org and hepatocellular carcinoma (Barré et al 2022;Zheng et al 2022), although conflicting results have been reported in some cohort studies.…”

Section: Discussionmentioning

confidence: 99%

“…A Meta-analysis of case-control studies and cohort studies suggested a potential inverse association between coffee consumption and the incidence and progression of liver cancer and cirrhosis (Bravi et al 2013;Sang et al 2013;Petrick et al 2015;Setiawan et al 2015;Kennedy et al 2016;Wang et al 2016;Alicandro et al 2017;Bravi et al 2017;Godos et al 2017;Kennedy et al 2017;Tamura et al 2018;Tran et al 2019;Wiltberger et al 2019;Bhurwal et al 2020;Di Maso et al 2021;Kennedy et al 2021;Kim et al 2021). Recent cohort studies found that coffee consumption may help reduce the risk of non-alcoholic fatty liver disease (NAFLD), hepatic fibrosis, and hepatocellular carcinoma (HCC) through inhibition of inflammation and oxidative stress (Tan et al 2021;Barré et al 2022;Zheng et al 2022). In addition, coffee consumption alters the composition of the duodenal microbiome in cirrhosis, suggesting that this may contribute to health benefits (Bajaj et al 2018;Hussain et al 2020).…”

Section: Cohort Studies Showing Effects Of Coffee Consumption On Chro...mentioning

confidence: 99%

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Roles of Coffee and Its Components in Liver Diseases

Pak,

Park,

Yoon

et al. 2023

DTT

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Coffee is a widely consumed beverage with multifaceted health benefits. While several studies have explored its effects on various diseases, limited reports have investigated its association with liver disease. Therefore, this review aimed to explore the effects of coffee consumption and its major coffee components on liver disease. Meta-analysis results have suggested that coffee consumption may reduce the risk of non-alcoholic fatty liver disease, hepatic fibrosis, and hepatocellular carcinoma, but the molecular mechanisms underlying these beneficial actions of coffee consumption remain elusive. Studying the individual components of coffee could help us better understand the mechanisms behind its liver protective effects. To clarify a more precise mechanism of coffee-related liver protective effects, the experimentally determined effects of each coffee component on liver diseases are also reviewed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Cohort Studies Showing Effects Of Coffee Consumption On Chro...mentioning

confidence: 99%

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Roles of Coffee and Its Components in Liver Diseases

Pak,

Park,

Yoon

et al. 2023

DTT

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“…Blood indexes such as fasting blood glucose (FBG), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), urea nitrogen (UREA), uric acid (UA), creatinine (CREA), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), homocysteine (HCY), and free triiodothyronine (FT3) were tested in the department of laboratory medicine and nuclear medicine of the Affiliated Hospital of Southwest Medical University. The fatty liver index (FLI) was calculated using the following formulaa: FLI = 1/[1 + exp(−x)] × 100, x = 0.953 × ln (triglycerides) (mg/dl) + 0.139 × BMI (kg/m2) + 0.718 × ln (γ-glutamyl-transferase) (U/L) + 0.053 × WC (cm)–15.745 ( Tan et al, 2021 ). After overnight fasting, the blood samples from all the participants were collected in the separation gel promoting tubes on the morning of the day of ultrasound examination.…”

Section: Methodsmentioning

confidence: 99%

Elevated Serum Regulator of Calcineurin 2 is Associated With an Increased Risk of Non-Alcoholic Fatty Liver Disease

et al. 2022

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Background: The promoting effect of the regulator of calcineurin 2 (RCAN2) in hepatic steatosis has been observed in animal studies. However, the association of RCAN2 with non-alcoholic fatty liver disease (NAFLD) in humans remains unclear. This study aimed to evaluate the expression of RCAN2 in the liver of mice with hepatic steatosis and in the serum of NAFLD patients and to explore the relationship between serum RCAN2 levels and NAFLD.Methods: The mRNA and protein expression of RCAN2 were detected by quantitative real-time PCR (qRT-PCR) and Western blot. NAFLD was diagnosed by abdominal ultrasonography. Circulating RCAN2 levels were measured by ELISA kits. The relationship between serum RCAN2 levels and NAFLD was assessed.Results: qRT-PCR and Western blot analysis showed that compared with the corresponding controls, the mRNA and protein expression of RCAN2 were significantly increased in the liver tissues of db/db and mice on a high-fat diet. Serum RCAN2 levels were markedly elevated in NAFLD patients compared with non-NAFLD subjects. Binary logistic regression analysis showed that serum RCAN2 levels were significantly associated with NAFLD. Receiver operation characteristic (ROC) curve analysis showed that serum RCAN2 might act as a predictive biomarker for NAFLD [area under the curve (AUC) = 0.663, 95% CI = 0.623–0.702], and the serum RCAN2/(AST/ALT) ratio displayed improved predictive accuracy (AUC = 0.816, 95% CI = 0.785–0.846).Conclusion: Elevated serum RCAN2 levels were associated with an increased risk of NAFLD. Serum RCAN2, especially the serum RCAN2/(AST/ALT) ratio, might be a candidate diagnostic marker for NAFLD.

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Effects of oily fish and its fatty acid intake on non-alcoholic fatty liver disease development among South Korean adults

Tan

Shin

2022

Front. Nutr.

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BackgroundThe benefits of fish fatty acid intake for non-alcoholic fatty liver disease (NAFLD) are rarely reported, although a previous study assessed the relationship between oily fish consumption and the prevalence of NAFLD.AimsWe investigated whether oily fish and fish-based monounsaturated fatty acids, polyunsaturated fatty acids, and omega-3 fatty acids affect the development of NAFLD in South Korean adults.MethodsIn this large-scale cohort study, 44,139 participants of the Health Examinees study were selected for analysis after 5 years of follow-up. NAFLD is diagnosed with a non-invasive index, the fatty liver index. Using multivariable Cox proportional hazards models, adjusted for age, body mass index, total energy intake, education, physical activity, smoking status, and drinking (alcohol) status, we calculated the hazard ratios and 95% confidence intervals.ResultsFor men, NAFLD had no statistically significant associations with quartiles of total oily fish or its fatty acid intake. However, among women, an inverse association was observed (all p for trend <0.05). Regarding the standard deviation (SD) increment of total oily fish or its fatty acid intake by one, all fatty acids from oily fish showed inverse associations for NAFLD in both men and women. After stratified analyses, we found that drinking status and menopause status were independent risk factors for NAFLD. Oily fish or its fatty acid intake has the same benefit pattern on metabolic dysfunction-associated fatty liver disease as NAFLD.ConclusionOily fish and its fatty acid intake showed a preventative benefit for NAFLD and metabolic dysfunction-associated fatty liver disease, especially in South Korean women.

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The Association Between Coffee Consumption and Nonalcoholic Fatty Liver Disease in the South Korean General Population

Cited by 3 publications

References 66 publications

Roles of Coffee and Its Components in Liver Diseases

Roles of Coffee and Its Components in Liver Diseases

Elevated Serum Regulator of Calcineurin 2 is Associated With an Increased Risk of Non-Alcoholic Fatty Liver Disease

Effects of oily fish and its fatty acid intake on non-alcoholic fatty liver disease development among South Korean adults

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