The Association Between Clearance of Human Papillomavirus After Conization for Cervical Cancer and Absence of Cancer

Abstract

Objectives:We assessed the relation between clearance of high-risk human papillomavirus (HR-HPV) after large loop excision of the transformation zone (LLETZ) and absence of residual disease, in women diagnosed with cervical cancer (CC) and adenocarcinoma in situ (AIS).Materials Methods: Data were collected from 92 women diagnosed with CC and AIS who were positive to HR-HPV and had a repeat cervical HPV test 3-12 weeks after LLETZ (in which CC/AIS were diagnosed) and before final surgical treatment. We compared characteristics of women with negative and positive HR-HPV after LLETZ. Results:The HR-HPV results after the LLETZ operation were negative in 40 women and positive in 52 women. The HR-HPV-negative group included a significantly higher incidence of AIS: 14 (35%) vs 5 (9.6%, p < .006). In the negative HR-HPV post-LLETZ group, 36 (90%) had normal histology and only 2 (5%) had cancer in the final histological specimen. Among 34 women who underwent radical hysterectomy/trachelectomy after LLETZ, a normal final histology was observed in 75% and 9% of those who were HR-HPV negative and HR-HPV positive, respectively (p < .0005). The positive predictive value for absence of residual cancer, with clearance of HR-HPV after LLETZ, was 95%.Conclusions: Clearance of HR-HPV from the cervix a short time after LLETZ has a high association with the absence of residual cancer in the final outcome, either in the pathology or the follow-up. Testing for HR-HPV a short time after LLETZ might serve as a parameter for risk assessment.

Effects of Sintilimab Plus Radiotherapy on Levels of Spondin-2 and Glucose Transporter-1 in Patients with Cervical Cancer

“…However, residual tumor tissues can be found after surgery, and tumor cells may further metastasize and spread if no effective treatment is conducted, resulting in adverse consequences. 11 Radiotherapy is also one of the important treatment means for cervical cancer, which can effectively inhibit the proliferation and reduce the activity of cancer cells using high-energy rays. Regular radiotherapy can effectively control tumor growth and prevent cancer cell metastasis.…”

Human papillomavirus infection

“…), and nearly all genital warts(4). Cutaneous lesions including epidermoid cysts, and laryngeal carcinoma) 6,11,32,16,30,40,33,36,37,46,38,41,48,55,72,73,96.…”

“…In India, it is the highest second level among women up to the age of 44 (1). The highest mortality rate was observed in Africa compared with Western Asia, North America and New Zealand (36). Finding that the occurrence of cervical cancer among African women renders the race inferior to white females (30).…”