The association between cigarette smoking and multiple sclerosis

Jafari, Naghmeh; Hintzen, Rogier Q.

doi:10.1016/j.jns.2011.09.008

Cited by 38 publications

(26 citation statements)

References 92 publications

(122 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cigarette smoking (CS) is a major risk factor for atherosclerotic vascular disease, Chronic Obstructive Pulmonary Disease (COPD), and cancer , and it affects the function of numerous other organs and systems . The effect of CS on hematopoietic stem/progenitor cells has been little explored.…”

Section: Introductionmentioning

confidence: 99%

Human Adipose-Derived Stem Cells Ameliorate Cigarette Smoke-Induced Murine Myelosuppression via Secretion of TSG-6

et al. 2015

View full text Add to dashboard Cite

Objective Bone marrow-derived hematopoietic stem and progenitor cells (HSC/HPC) are critical to homeostasis and tissue repair. The aims of this study were to delineate the myelotoxicity of cigarette smoking (CS) in a murine model, to explore human adipose-derived stem cells (hASC) as a novel approach to mitigate this toxicity, and to identify key mediating factors for ASC activities. Methods C57BL/6 mice were exposed to CS with or without i.v. injection of regular or siRNA-transfected hASC. For in vitro experiments, cigarette smoke extract (CSE) was used to mimic the toxicity of CS exposure. Analysis of bone marrow hematopoietic progenitor cells (HPC) were performed both by flow cytometry and colony forming unit assays. Results In this study, we demonstrate that as few as three days of CS exposure result in marked cycling arrest and diminished clonogenic capacity of HPC, followed by depletion of phenotypically-defined HSC/HPC. Intravenous injection of hASC substantially ameliorated both acute and chronic CS-induced myelosuppression. This effect was specifically dependent on the anti-inflammatory factor TSG-6, which is induced from xenografted hASC, primarily located in the lung and capable of responding to host inflammatory signals. Gene expression analysis within bone marrow HSC/HPC revealed several specific signaling molecules altered by CS and normalized by hASC. Conclusion Our results suggest that systemic administration of hASC or TSG-6 may be novel approaches to reverse cigarette smoking-induced myelosuppression.

show abstract

Section: Introductionmentioning

confidence: 99%

Human Adipose-Derived Stem Cells Ameliorate Cigarette Smoke-Induced Murine Myelosuppression via Secretion of TSG-6

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Though there are some inconsistencies the accumulated epidemiological evidence points to tobacco smoke being correlated with increased susceptibility [2,[6][7][8][9][10], faster clinical progression [11][12][13][14][15][16][17] and increased mortality in patients with MS [18][19][20][21][22][23]. The pathological basis for this is currently unknown but there are some putative mechanisms.…”

Section: Pathological Basismentioning

confidence: 99%

“…Multiple retrospective and prospective studies since 1965, including case-control and cohort types, have shown increased susceptibility to MS [2,[6][7][8][9][10]. The reported average risk ratio (RR) varied between 1.4 and 1.8 and a recent meta-analysis by Handel et al calculated the RR as 1.48 (95% CI: 1.35-1.63; p < 10 -15 ) when conservatively limiting the analysis to ten studies where smoking behavior was described prior to disease onset and the nonconservative RR as 1.52, (95% CI: 1.39-1.66; p < 10 -19 ) [2].…”

Section: Smoking and Susceptibility To Msmentioning

confidence: 99%

What Role Does Tobacco Smoking Play in Multiple Sclerosis Disability and Mortality? A Review of the Evidence

Weston

Constantinescu

2015

Neurodegener. Dis. Manag.

View full text Add to dashboard Cite

There is increasing evidence of tobacco smoking as an associative factor in multiple sclerosis (MS). Numerous studies have been conducted investigating the effects of smoking before the onset of MS as well as its impact on disease course. This special report reviews the available evidence and summarizes the contribution of smoking to increased mortality in patients with MS. It also explores some putative mechanisms for the involvement of tobacco constituents in the pathology of MS and the effects of smoking on disease-modifying treatments.

show abstract

“…The cause of MS is not known, but several factors have been shown to be associated with the risk of developing this disease including vitamins [1], smoking [2], genetic factors [3, 4], and infections [5]. A link between the first clinical attack or relapses in MS and infections has been proposed on the basis of epidemiological studies [6].…”

Section: Introductionmentioning

confidence: 99%

Systemic Escherichia coli infection does not influence clinical symptoms and neurodegeneration in experimental autoimmune encephalomyelitis

et al. 2015

View full text Add to dashboard Cite

BackgroundSystemic infections can influence the course of multiple sclerosis (MS), especially by driving recurrent acute episodes. The question whether the infection enhances tissue damage is of great clinical importance and cannot easily be assessed in clinical trials. Here, we investigated the effects of a systemic infection with Escherichia coli, a Gram-negative bacterium frequently causing urinary tract infections, on the clinical course as well as on neurodegeneration in experimental autoimmune encephalomyelitis (EAE), an animal model of MS.MethodsRats were immunized with myelin oligodendrocyte glycoprotein (MOG1–125) and challenged intraperitoneally with live E. coli K1 in the preclinical or in the clinical phase of the disease. To ensure the survival of animals, antibiotic treatment with ceftriaxone was initiated 36 h after the infection and continued for 3 consecutive days.ResultsSystemic infection with E. coli did not influence the onset of clinical EAE symptoms or disease severity. Analysis of the optic nerve and retinal ganglion cells revealed no significant changes in the extent of inflammatory infiltrates, demyelination and neurodegeneration after E. coli infection.ConclusionsWe could not confirm the detrimental effect of lipopolysaccharide-induced systemic inflammation, a model frequently used to mimic the bacterial infection, previously observed in animal models of MS. Our results indicate that the effect of an acute E. coli infection on the course of MS is less pronounced than suspected and underline the need for adequate models to test the role of systemic infections in the pathogenesis of MS.

show abstract

The association between cigarette smoking and multiple sclerosis

Cited by 38 publications

References 92 publications

Human Adipose-Derived Stem Cells Ameliorate Cigarette Smoke-Induced Murine Myelosuppression via Secretion of TSG-6

Human Adipose-Derived Stem Cells Ameliorate Cigarette Smoke-Induced Murine Myelosuppression via Secretion of TSG-6

What Role Does Tobacco Smoking Play in Multiple Sclerosis Disability and Mortality? A Review of the Evidence

Systemic Escherichia coli infection does not influence clinical symptoms and neurodegeneration in experimental autoimmune encephalomyelitis

Contact Info

Product

Resources

About